GPR12: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Probable G-protein coupled receptor 12''' is a [[protein]] that in humans is encoded by the ''GPR12'' [[gene]].<ref name="pmid8262253">{{cite journal |vauthors=Saeki Y, Ueno S, Mizuno R, Nishimura T, Fujimura H, Nagai Y, Yanagihara T | title = Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system | journal = FEBS Lett | volume = 336 | issue = 2 | pages = 317–322 |date=Jan 1994 | pmid = 8262253 | pmc =  | doi =10.1016/0014-5793(93)80828-I  }}</ref><ref name="pmid8530049">{{cite journal |vauthors=Song ZH, Modi W, Bonner TI | title = Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors | journal = Genomics | volume = 28 | issue = 2 | pages = 347–349 |date=Feb 1996 | pmid = 8530049 | pmc = | doi = 10.1006/geno.1995.1154 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GPR12 G protein-coupled receptor 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2835| accessdate = }}</ref>
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The gene product of GPR12 is an [[orphan receptor]], meaning that its endogenous [[ligand]] is currently unknown. Gene disruption of GPR12 in mice results in [[dyslipidemia]] and obesity<ref>{{Cite journal| doi = 10.1016/j.bbrc.2006.07.090| issn = 0006-291X| volume = 348| issue = 2| pages = 359–366| last1 = Bjursell| first1 = Mikael| last2 = Gerdin| first2 = Anna-Karin| last3 = Jönsson| first3 = Marie| last4 = Surve| first4 = Vikas V.| last5 = Svensson| first5 = Lennart| last6 = Huang| first6 = Xu-Feng| last7 = Törnell| first7 = Jan| last8 = Bohlooly-Y| first8 = Mohammad| title = G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice| journal = Biochemical and Biophysical Research Communications| date = 2006-09-22| pmid = 16887097}}</ref>.
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = G protein-coupled receptor 12
| HGNCid = 4466
| Symbol = GPR12
| AltSymbols =; GPCR12; GPCR21; MGC138349; MGC138351
| OMIM = 600752
| ECnumber =
| Homologene = 3868
| MGIid = 101909
| GeneAtlas_image1 = PBB_GE_GPR12_214558_at_tn.png
| Function = {{GNF_GO|id=GO:0001619 |text = lysosphingolipid and lysophosphatidic acid receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006874 |text = cellular calcium ion homeostasis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2835
    | Hs_Ensembl = ENSG00000132975
    | Hs_RefseqProtein = NP_005279
    | Hs_RefseqmRNA = NM_005288
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 13
    | Hs_GenLoc_start = 26230447
    | Hs_GenLoc_end = 26232108
    | Hs_Uniprot = P47775
    | Mm_EntrezGene = 14738
    | Mm_Ensembl = ENSMUSG00000041468
    | Mm_RefseqmRNA = NM_001010941
    | Mm_RefseqProtein = NP_001010941
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 146892499
    | Mm_GenLoc_end = 146895588
    | Mm_Uniprot = P35412
  }}
}}
'''G protein-coupled receptor 12''', also known as '''GPR12''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPR12 G protein-coupled receptor 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2835| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Saeki Y, Ueno S, Mizuno R, ''et al.'' |title=Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system. |journal=FEBS Lett. |volume=336 |issue= 2 |pages= 317-22 |year= 1994 |pmid= 8262253 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Song ZH, Modi W, Bonner TI |title=Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors. |journal=Genomics |volume=28 |issue= 2 |pages= 347-9 |year= 1996 |pmid= 8530049 |doi= 10.1006/geno.1995.1154 }}
*{{cite journal  | author=Uhlenbrock K |title=Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells |journal=Cell. Physiol. Biochem. |volume=13 |issue= 2 |pages= 75–84 |year= 2003 |pmid= 12649592 |doi= 10.1159/000070251 |name-list-format=vanc| author2=Huber J  | author3=Ardati A  | display-authors=3  | last4=Busch  | first4=Andreas  | last5=Kostenis  | first5=Evi }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Dunham A |title=The DNA sequence and analysis of human chromosome 13 |journal=Nature |volume=428 |issue= 6982 |pages= 522–528 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 | pmc=2665288  |name-list-format=vanc| author2=Matthews LH  | author3=Burton J  | display-authors=3  | last4=Ashurst  | first4=J. L.  | last5=Howe  | first5=K. L.  | last6=Ashcroft  | first6=K. J.  | last7=Beare  | first7=D. M.  | last8=Burford  | first8=D. C.  | last9=Hunt  | first9=S. E. }}
*{{cite journal  | author=Uhlenbrock K, Huber J, Ardati A, ''et al.'' |title=Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells. |journal=Cell. Physiol. Biochem. |volume=13 |issue= 2 |pages= 75-84 |year= 2003 |pmid= 12649592 |doi= 10.1159/000070251 }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Dunham A, Matthews LH, Burton J, ''et al.'' |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522-8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
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[[Category:G protein coupled receptors]]
[[Category:G protein coupled receptors]]
{{WikiDoc Sources}}
 
 
{{transmembranereceptor-stub}}

Revision as of 08:57, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Probable G-protein coupled receptor 12 is a protein that in humans is encoded by the GPR12 gene.[1][2][3]

The gene product of GPR12 is an orphan receptor, meaning that its endogenous ligand is currently unknown. Gene disruption of GPR12 in mice results in dyslipidemia and obesity[4].


References

  1. ↑ Saeki Y, Ueno S, Mizuno R, Nishimura T, Fujimura H, Nagai Y, Yanagihara T (Jan 1994). "Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system". FEBS Lett. 336 (2): 317–322. doi:10.1016/0014-5793(93)80828-I. PMID 8262253.
  2. ↑ Song ZH, Modi W, Bonner TI (Feb 1996). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics. 28 (2): 347–349. doi:10.1006/geno.1995.1154. PMID 8530049.
  3. ↑ "Entrez Gene: GPR12 G protein-coupled receptor 12".
  4. ↑ Bjursell, Mikael; Gerdin, Anna-Karin; Jönsson, Marie; Surve, Vikas V.; Svensson, Lennart; Huang, Xu-Feng; Törnell, Jan; Bohlooly-Y, Mohammad (2006-09-22). "G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice". Biochemical and Biophysical Research Communications. 348 (2): 359–366. doi:10.1016/j.bbrc.2006.07.090. ISSN 0006-291X. PMID 16887097.

Further reading


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