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{{Infobox_gene}}
{{PBB_Controls
'''G-protein coupled receptor 3''' is a [[protein]] that in humans is encoded by the ''GPR3'' [[gene]].<ref name="pmid7851889">{{cite journal |vauthors=Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF | title = Cloning of human genes encoding novel G protein-coupled receptors | journal = Genomics | volume = 23 | issue = 3 | pages = 609–18 |date=Mar 1995 | pmid = 7851889 | pmc = | doi = 10.1006/geno.1994.1549 }}</ref><ref name="entrez">{{Cite web| title = Entrez Gene: GPR3 G protein-coupled receptor 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2827| accessdate = }}</ref> The [[protein]] encoded by this gene is a member of the [[G protein-coupled receptor]] family of [[transmembrane receptor]]s and is involved in [[signal transduction]].
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==Function==
{{GNF_Protein_box
GPR3 activates [[adenylate cyclase]] in the absence of [[ligand (biochemistry)|ligand]].<ref name="pmid7639700">{{cite journal |vauthors=Eggerickx D, Denef JF, Labbe O, Hayashi Y, Refetoff S, Vassart G, Parmentier M, Libert F | title = Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase | journal = Biochem. J. | volume = 309 ( Pt 3) | issue = Pt 3| pages = 837–43 |date=August 1995 | pmid = 7639700 | pmc = 1135708 | url =  }}</ref> GPR3 is expressed in mammalian [[oocyte]]s where it maintains [[Meiosis|meiotic]] arrest and is thought to be a communication link between oocytes and the surrounding somatic tissue.<ref name="pmid15591206">{{cite journal |vauthors=Mehlmann LM, Saeki Y, Tanaka S, Brennan TJ, Evsikov AV, Pendola FL, Knowles BB, Eppig JJ, Jaffe LA |title = The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes | journal = Science |volume = 306 | issue = 5703 | pages = 1947–50 |date=December 2004 | pmid = 15591206 | doi = 10.1126/science.1103974 | url = }}</ref> It has been proposed that [[sphingosine 1-phosphate]] (S1P) and sphingosylphosphorylcholine (SPC) are GPR3 ligands,<ref name="pmid12220620">{{cite journal |vauthors=Uhlenbrock K, Gassenhuber H, Kostenis E | title = Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors | journal = Cell. Signal. | volume = 14 | issue = 11 | pages = 941–53 |date=November 2002 | pmid = 12220620 | doi = 10.1016/S0898-6568(02)00041-4| url =  }}</ref><ref name="pmid16229830">{{cite journal |vauthors=Hinckley M, Vaccari S, Horner K, Chen R, Conti M | title = The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes | journal = Dev. Biol. | volume = 287 | issue = 2 | pages = 249–61 |date=November 2005 | pmid = 16229830 | doi = 10.1016/j.ydbio.2005.08.019 | url = }}</ref> however this result was not confirmed in a [[arrestin beta 1|β-arrestin]] recruitment assay.<ref name="pmid19286662">{{cite journal |vauthors=Yin H, Chu A, Li W, Wang B, Shelton F, Otero F, Nguyen DG, Caldwell JS, Chen YA | title = Lipid G Protein-coupled Receptor Ligand Identification Using β-Arrestin PathHunter™ Assay | journal = J. Biol. Chem. | volume = 284 | issue = 18 | pages = 12328–38 |date=May 2009 | pmid = 19286662 | pmc = 2673301 | doi = 10.1074/jbc.M806516200 | url = }}</ref>
| image =
| image_source = 
| PDB =
| Name = G protein-coupled receptor 3
| HGNCid = 4484
| Symbol = GPR3
| AltSymbols =; ACCA
| OMIM = 600241
| ECnumber =
| Homologene = 31303
| MGIid = 101908
| GeneAtlas_image1 = PBB_GE_GPR3_214613_at_tn.png
  | Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007189 |text = G-protein signaling, adenylate cyclase activating pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2827
    | Hs_Ensembl = ENSG00000181773
    | Hs_RefseqProtein = NP_005272
    | Hs_RefseqmRNA = NM_005281
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 27591735
    | Hs_GenLoc_end = 27594905
    | Hs_Uniprot = P46089
    | Mm_EntrezGene = 14748
    | Mm_Ensembl = ENSMUSG00000049649
    | Mm_RefseqmRNA = NM_008154
    | Mm_RefseqProtein = NP_032180
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 132481412
    | Mm_GenLoc_end = 132484583
    | Mm_Uniprot = Q3USD4
  }}
}}
'''G protein-coupled receptor 3''', also known as '''GPR3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPR3 G protein-coupled receptor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2827| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==References==
{{PBB_Summary
{{Reflist}}
| section_title =
| summary_text =
}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{Refbegin| 2}}
{{PBB_Further_reading
*{{Cite journal   |vauthors=Eggerickx D, Denef JF, Labbe O, etal |title=Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase |journal=Biochem. J. |volume=309 ( Pt 3) |issue=  Pt 3|pages= 837–43 |year= 1995 |pmid= 7639700 |doi= | pmc=1135708 }}
| citations =
*{{Cite journal   |vauthors=Iismaa TP, Kiefer J, Liu ML, etal |title=Isolation and chromosomal localization of a novel human G-protein-coupled receptor (GPR3) expressed predominantly in the central nervous system |journal=Genomics |volume=24 |issue= 2 |pages= 391–4 |year= 1995 |pmid= 7698767 |doi= 10.1006/geno.1994.1635 }}
*{{cite journal | author=Eggerickx D, Denef JF, Labbe O, ''et al.'' |title=Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase. |journal=Biochem. J. |volume=309 ( Pt 3) |issue=  |pages= 837-43 |year= 1995 |pmid= 7639700 |doi=  }}
*{{Cite journal   |vauthors=Heiber M, Docherty JM, Shah G, etal |title=Isolation of three novel human genes encoding G protein-coupled receptors |journal=DNA Cell Biol. |volume=14 |issue= 1 |pages= 25–35 |year= 1995 |pmid= 7832990 |doi=10.1089/dna.1995.14.25  }}
*{{cite journal | author=Iismaa TP, Kiefer J, Liu ML, ''et al.'' |title=Isolation and chromosomal localization of a novel human G-protein-coupled receptor (GPR3) expressed predominantly in the central nervous system. |journal=Genomics |volume=24 |issue= 2 |pages= 391-4 |year= 1995 |pmid= 7698767 |doi= 10.1006/geno.1994.1635 }}
*{{Cite journal  |vauthors=Song ZH, Modi W, Bonner TI |title=Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors |journal=Genomics |volume=28 |issue= 2 |pages= 347–9 |year= 1996 |pmid= 8530049 |doi= 10.1006/geno.1995.1154 }}
*{{cite journal | author=Heiber M, Docherty JM, Shah G, ''et al.'' |title=Isolation of three novel human genes encoding G protein-coupled receptors. |journal=DNA Cell Biol. |volume=14 |issue= 1 |pages= 25-35 |year= 1995 |pmid= 7832990 |doi= }}
*{{Cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Marchese A, Docherty JM, Nguyen T, ''et al.'' |title=Cloning of human genes encoding novel G protein-coupled receptors. |journal=Genomics |volume=23 |issue= 3 |pages= 609-18 |year= 1995 |pmid= 7851889 |doi= 10.1006/geno.1994.1549 }}
*{{Cite journal   |vauthors=Uhlenbrock K, Huber J, Ardati A, etal |title=Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells |journal=Cell. Physiol. Biochem. |volume=13 |issue= 2 |pages= 75–84 |year= 2003 |pmid= 12649592 |doi= 10.1159/000070251 }}
*{{cite journal  | author=Song ZH, Modi W, Bonner TI |title=Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors. |journal=Genomics |volume=28 |issue= 2 |pages= 347-9 |year= 1996 |pmid= 8530049 |doi= 10.1006/geno.1995.1154 }}
*{{Cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{Cite journal   |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal | author=Uhlenbrock K, Huber J, Ardati A, ''et al.'' |title=Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells. |journal=Cell. Physiol. Biochem. |volume=13 |issue= 2 |pages= 75-84 |year= 2003 |pmid= 12649592 |doi= 10.1159/000070251 }}
{{Refend}}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
}}
{{refend}}


{{membrane-protein-stub}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
{{DEFAULTSORT:Gpr3}}
[[Category:G protein coupled receptors]]
[[Category:G protein coupled receptors]]
{{WikiDoc Sources}}
 
 
{{Transmembranereceptor-stub}}

Revision as of 09:00, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

G-protein coupled receptor 3 is a protein that in humans is encoded by the GPR3 gene.[1][2] The protein encoded by this gene is a member of the G protein-coupled receptor family of transmembrane receptors and is involved in signal transduction.

Function

GPR3 activates adenylate cyclase in the absence of ligand.[3] GPR3 is expressed in mammalian oocytes where it maintains meiotic arrest and is thought to be a communication link between oocytes and the surrounding somatic tissue.[4] It has been proposed that sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine (SPC) are GPR3 ligands,[5][6] however this result was not confirmed in a β-arrestin recruitment assay.[7]

References

  1. ↑ Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF (Mar 1995). "Cloning of human genes encoding novel G protein-coupled receptors". Genomics. 23 (3): 609–18. doi:10.1006/geno.1994.1549. PMID 7851889.
  2. ↑ "Entrez Gene: GPR3 G protein-coupled receptor 3".
  3. ↑ Eggerickx D, Denef JF, Labbe O, Hayashi Y, Refetoff S, Vassart G, Parmentier M, Libert F (August 1995). "Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase". Biochem. J. 309 ( Pt 3) (Pt 3): 837–43. PMC 1135708. PMID 7639700.
  4. ↑ Mehlmann LM, Saeki Y, Tanaka S, Brennan TJ, Evsikov AV, Pendola FL, Knowles BB, Eppig JJ, Jaffe LA (December 2004). "The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes". Science. 306 (5703): 1947–50. doi:10.1126/science.1103974. PMID 15591206.
  5. ↑ Uhlenbrock K, Gassenhuber H, Kostenis E (November 2002). "Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors". Cell. Signal. 14 (11): 941–53. doi:10.1016/S0898-6568(02)00041-4. PMID 12220620.
  6. ↑ Hinckley M, Vaccari S, Horner K, Chen R, Conti M (November 2005). "The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes". Dev. Biol. 287 (2): 249–61. doi:10.1016/j.ydbio.2005.08.019. PMID 16229830.
  7. ↑ Yin H, Chu A, Li W, Wang B, Shelton F, Otero F, Nguyen DG, Caldwell JS, Chen YA (May 2009). "Lipid G Protein-coupled Receptor Ligand Identification Using β-Arrestin PathHunter™ Assay". J. Biol. Chem. 284 (18): 12328–38. doi:10.1074/jbc.M806516200. PMC 2673301. PMID 19286662.

Further reading


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