Melanocortin 5 receptor: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Melanocortin receptor 5''' is a [[protein]] that in humans is encoded by the ''MC5R'' [[gene]].<ref name="pmid8396929">{{cite journal | vauthors = Chhajlani V, Muceniece R, Wikberg JE | title = Molecular cloning of a novel human melanocortin receptor | journal = Biochemical and Biophysical Research Communications | volume = 195 | issue = 2 | pages = 866–73 | date = September 1993 | pmid = 8396929 | pmc =  | doi = 10.1006/bbrc.1993.2125 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MC5R melanocortin 5 receptor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4161 | accessdate = }}</ref> It is located on the chromosome 18 in the human [[genome]].<ref name="entrez" /> When the melanocortin 5 receptor was disrupted in [[Genetically modified organism|transgenic mice]], it induced disruption of their [[exocrine gland]]s and resulted in decreased production of [[Sebaceous gland|sebum]].<ref name = "Thiboutot_2000">{{cite journal | vauthors = Thiboutot D, Sivarajah A, Gilliland K, Cong Z, Clawson G | title = The melanocortin 5 receptor is expressed in human sebaceous glands and rat preputial cells | journal = The Journal of Investigative Dermatology | volume = 115 | issue = 4 | pages = 614–9 | date = October 2000 | pmid = 10998132 | doi = 10.1046/j.1523-1747.2000.00094.x }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==Physiology==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Melanocortin 5 receptor
| HGNCid = 6933
| Symbol = MC5R
| AltSymbols =;
| OMIM = 600042
| ECnumber = 
| Homologene = 4321
| MGIid = 99420
| GeneAtlas_image1 = PBB_GE_MC5R_208565_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004977 |text = melanocortin receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007187 |text = G-protein signaling, coupled to cyclic nucleotide second messenger}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4161
    | Hs_Ensembl = ENSG00000176136
    | Hs_RefseqProtein = NP_005904
    | Hs_RefseqmRNA = NM_005913
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 18
    | Hs_GenLoc_start = 13815543
    | Hs_GenLoc_end = 13816861
    | Hs_Uniprot = P33032
    | Mm_EntrezGene = 17203
    | Mm_Ensembl = ENSMUSG00000007480
    | Mm_RefseqmRNA = NM_013596
    | Mm_RefseqProtein = NP_038624
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 68462965
    | Mm_GenLoc_end = 68465092
    | Mm_Uniprot = Q496T0
  }}
}}
'''Melanocortin 5 receptor''', also known as '''MC5R''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MC5R melanocortin 5 receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4161 | accessdate = }}</ref> It is located on the chromosome 18 in the human [[genome]].<ref name="entrez" /> When the melanocortin 5 receptor was disrupted in [[Genetically modified organism|transgenic mice]], it induced disruption of their [[exocrine gland]]s and resulted in decreased production of [[Sebaceous gland|sebum]].<ref>{{cite journal
| last=Thiboutot | first=Diane
| coauthors=Sivarajah, Aruntha; Gilliland, Kathryn ; Cong, Zhaoyuan; Clawson, Gary
| title=The Melanocortin 5 Receptor is Expressed in Human Sebaceous Glands and Rat Preputial Cells
| journal=Journal of Investigative Dermatology
| year=2000 | volume=115 | pages=614–619
| doi=10.1046/j.1523-1747.2000.00094.x
| url=http://www.nature.com/jid/journal/v115/n4/abs/5600836a.html
| accessdate=2008-01-04
}}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
MC5R is necessary for normal [[sebum]] production.<ref name = "Thiboutot_2000"/><ref name="ReferenceA">{{cite journal | vauthors = Chen W, Kelly MA, Opitz-Araya X, Thomas RE, Low MJ, Cone RD | title = Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides | journal = Cell | volume = 91 | issue = 6 | pages = 789–98 | date = December 1997 | pmid = 9413988 | doi = 10.1016/S0092-8674(00)80467-5 }}</ref><ref>{{cite journal | vauthors = Zhang L, Li WH, Anthonavage M, Pappas A, Rossetti D, Cavender D, Seiberg M, Eisinger M | title = Melanocortin-5 receptor and sebogenesis. | journal = Eur J Pharmacol | volume = 660 | issue = 1 | pages = 202–206 | date = June 2011 | pmid = 21215742 | doi = 10.1016/j.ejphar.2010.10.100 }}</ref> Stimulation of MC5R promotes [[fatty acid oxidation]] in [[skeletal muscle]]<ref>{{cite journal | vauthors = An JJ, Rhee Y, Kim SH, Kim DM, Han DH, Hwang JH, Jin YJ, Cha BS, Baik JH, Lee WT, Lim SK | title = Peripheral effect of alpha-melanocyte-stimulating hormone on fatty acid oxidation in skeletal muscle | journal = The Journal of Biological Chemistry | volume = 282 | issue = 5 | pages = 2862–70 | date = February 2007 | pmid = 17127674 | doi = 10.1074/jbc.M603454200 }}</ref> and [[Lipolysis|lypolysis]] in [[adipocytes]].<ref>{{cite journal | vauthors = Møller CL, Raun K, Jacobsen ML, Pedersen TÅ, Holst B, Conde-Frieboes KW, Wulff BS | title = Characterization of murine melanocortin receptors mediating adipocyte lipolysis and examination of signalling pathways involved. | journal = Mol Cell Endocrinol. | volume = 341 | issue = 1–2 | pages = 9–17 | date = July 2011 | pmid = 21616121 | doi = 10.1016/j.mce.2011.03.010 }}</ref> MC5R is essential for [[erythrocyte]] differentiation.<ref>{{cite journal | vauthors = Simamura E, Arikawa T, Ikeda T, Shimada H, Shoji H, Masuta H, Nakajima Y, Otani H, Yonekura H, Hatta T | title = Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5. | journal = PLOS ONE | volume = 10 | issue = 4 | pages = e0123232 | date = April 2015 | pmid = 25860801 | doi = 10.1371/journal.pone.0123232 | pmc=4393082}}</ref> MC5R is involved in [[inflammation]].<ref>{{cite journal | vauthors = Lee DJ, Taylor AW | title = Both MC5r and A2Ar are required for protective regulatory immunity in the spleen of post-experimental autoimmune uveitis in mice. | journal = J. Immunol. | volume = 191| issue = 8 | pages = 4103–4111 | date = October 2013 | pmid = 24043903 | doi = 10.4049/jimmunol.1300182 | pmc=3796047}}</ref><ref>{{cite journal | vauthors = Jun DJ, Na KY, Kim W, Kwak D, Kwon EJ, Yoon JH, Yea K, Lee H, Kim J, Suh PG, Ryu SH, Kim KT | title = Melanocortins induce interleukin 6 gene expression and secretion through melanocortin receptors 2 and 5 in 3T3-L1 adipocytes. | journal = J Mol Endocrinol. | volume = 44 | issue = 4 | pages = 225–236 | date = April 2010 | pmid = 20089716 | doi = 10.1677/JME-09-0161 | pmc=3058511}}</ref> MC5R helps maintain [[Endotherm|thermal homeostasis]].<ref name="ReferenceA"/><ref>{{cite journal | vauthors = Lute B, Jou W, Lateef DM, Goldgof M, Xiao C, Piñol RA, Kravitz AV, Miller NR, Huang YG, Girardet C, Butler AA, Gavrilova O, Reitman ML | title = Biphasic effect of melanocortin agonists on metabolic rate and body temperature. | journal = Cell Metab. | volume = 20 | issue = 2 | pages = 333–345 | date = August 2014 | pmid = 24981835 | doi = 10.1016/j.cmet.2014.05.021 | pmc=4126889}}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==See also==
MC5R is expressed in the brain at different levels depending on [[physical activity]].<ref>{{cite journal | vauthors = Shukla C, Britton SL, Koch LG, Novak CM | title = Region-specific differences in brain melanocortin receptors in rats of the lean phenotype. | journal = Neuroreport. | volume = 23 | issue = 10 | pages = 596–600 | date = July 2012 | pmid = 22643233 | doi = 10.1097/WNR.0b013e328354f5c1 | pmc=3831884}}</ref>
 
=== Pheromones ===
 
MC5R is heavily expressed in the [[preputial gland]] in mice (a modified [[sebaceous gland]] involved in [[pheromone]] production). MC5R deficiency in male mice decreases aggressive behavior, promotes defensive behavior and encourages other male mice to attack MC5R-deficient males through pheremonal signals.<ref>{{cite journal | vauthors = Morgan C, Thomas RE, Cone RD | title = Melanocortin-5 receptor deficiency promotes defensive behavior in male mice. | journal = Horm Behav. | volume = 45 | issue = 1 | pages = 56–63 | date = January 2004 | pmid = 14733892 }}</ref><ref>{{cite journal | vauthors = Morgan C, Thomas RE, Ma W, Novotny MV, Cone RD | title = Melanocortin-5 receptor deficiency reduces a pheromonal signal for aggression in male mice. | journal = Chem Senses | volume = 29 | issue = 2 | pages = 111–115 | date = February 2004 | pmid = 14977807 | doi=10.1093/chemse/bjh011}}</ref><ref>{{cite journal | vauthors = Morgan C, Cone RD | title = Melanocortin-5 receptor deficiency in mice blocks a novel pathway influencing pheromone-induced aggression. | journal = Behav Genet. | volume = 36 | issue = 2 | pages = 291–300 | date = January 2006 | pmid = 16408249 | doi=10.1007/s10519-005-9024-9}}</ref>
 
===MRAP===
 
[[ACTH receptor|Melanocortin 2 Receptor]] accessory protein (MRAP) traps MC5R protein inside cells.<ref>{{cite journal | vauthors = Sebag JA, Hinkle PM | title = Opposite effects of the melanocortin-2 (MC2) receptor accessory protein MRAP on MC2 and MC5 receptor dimerization and trafficking. | journal = J Biol Chem | volume = 284 | issue = 34 | pages = 22641–22648 | date = August 2009 | pmid = 19535343 | doi = 10.1074/jbc.M109.022400 | pmc=2755671}}</ref>
 
== See also ==
* [[Melanocortin receptor]]
* [[Melanocortin receptor]]


==References==
== References ==
{{reflist|2}}
{{reflist|33em}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin|33em}}
{{PBB_Further_reading
* {{cite journal | vauthors = Fathi Z, Iben LG, Parker EM | title = Cloning, expression, and tissue distribution of a fifth melanocortin receptor subtype | journal = Neurochemical Research | volume = 20 | issue = 1 | pages = 107–13 | date = January 1995 | pmid = 7739752 | doi = 10.1007/BF00995160 }}
| citations =
* {{cite journal | vauthors = Chowdhary BP, Gustavsson I, Wikberg JE, Chhajlani V | title = Localization of the human melanocortin-5 receptor gene (MC5R) to chromosome band 18p11.2 by fluorescence in situ hybridization | journal = Cytogenetics and Cell Genetics | volume = 68 | issue = 1–2 | pages = 79–81 | year = 1994 | pmid = 7956366 | doi = 10.1159/000133895 }}
*{{cite journal | author=Fathi Z, Iben LG, Parker EM |title=Cloning, expression, and tissue distribution of a fifth melanocortin receptor subtype. |journal=Neurochem. Res. |volume=20 |issue= 1 |pages= 107-13 |year= 1995 |pmid= 7739752 |doi= }}
* {{cite journal | vauthors = Griffon N, Mignon V, Facchinetti P, Diaz J, Schwartz JC, Sokoloff P | title = Molecular cloning and characterization of the rat fifth melanocortin receptor | journal = Biochemical and Biophysical Research Communications | volume = 200 | issue = 2 | pages = 1007–14 | date = April 1994 | pmid = 8179577 | doi = 10.1006/bbrc.1994.1550 }}
*{{cite journal | author=Chowdhary BP, Gustavsson I, Wikberg JE, Chhajlani V |title=Localization of the human melanocortin-5 receptor gene (MC5R) to chromosome band 18p11.2 by fluorescence in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=68 |issue= 1-2 |pages= 79-81 |year= 1994 |pmid= 7956366 |doi= }}
* {{cite journal | vauthors = Gantz I, Shimoto Y, Konda Y, Miwa H, Dickinson CJ, Yamada T | title = Molecular cloning, expression, and characterization of a fifth melanocortin receptor | journal = Biochemical and Biophysical Research Communications | volume = 200 | issue = 3 | pages = 1214–20 | date = May 1994 | pmid = 8185570 | doi = 10.1006/bbrc.1994.1580 }}
*{{cite journal | author=Griffon N, Mignon V, Facchinetti P, ''et al.'' |title=Molecular cloning and characterization of the rat fifth melanocortin receptor. |journal=Biochem. Biophys. Res. Commun. |volume=200 |issue= 2 |pages= 1007-14 |year= 1994 |pmid= 8179577 |doi= }}
* {{cite journal | vauthors = Chhajlani V | title = Distribution of cDNA for melanocortin receptor subtypes in human tissues | journal = Biochemistry and Molecular Biology International | volume = 38 | issue = 1 | pages = 73–80 | date = February 1996 | pmid = 8932521 | doi =  }}
*{{cite journal | author=Gantz I, Shimoto Y, Konda Y, ''et al.'' |title=Molecular cloning, expression, and characterization of a fifth melanocortin receptor. |journal=Biochem. Biophys. Res. Commun. |volume=200 |issue= 3 |pages= 1214-20 |year= 1994 |pmid= 8185570 |doi= 10.1006/bbrc.1994.1580 }}
* {{cite journal | vauthors = Yang YK, Ollmann MM, Wilson BD, Dickinson C, Yamada T, Barsh GS, Gantz I | title = Effects of recombinant agouti-signaling protein on melanocortin action | journal = Molecular Endocrinology | volume = 11 | issue = 3 | pages = 274–80 | date = March 1997 | pmid = 9058374 | doi = 10.1210/me.11.3.274 }}
*{{cite journal | author=Chhajlani V, Muceniece R, Wikberg JE |title=Molecular cloning of a novel human melanocortin receptor. |journal=Biochem. Biophys. Res. Commun. |volume=195 |issue= 2 |pages= 866-73 |year= 1993 |pmid= 8396929 |doi= 10.1006/bbrc.1993.2125 }}
* {{cite journal | vauthors = Frändberg PA, Xu X, Chhajlani V | title = Glutamine235 and arginine272 in human melanocortin 5 receptor determines its low affinity to MSH | journal = Biochemical and Biophysical Research Communications | volume = 236 | issue = 2 | pages = 489–92 | date = July 1997 | pmid = 9240466 | doi = 10.1006/bbrc.1997.6994 }}
*{{cite journal  | author=Chhajlani V |title=Distribution of cDNA for melanocortin receptor subtypes in human tissues. |journal=Biochem. Mol. Biol. Int. |volume=38 |issue= 1 |pages= 73-80 |year= 1997 |pmid= 8932521 |doi=  }}
* {{cite journal | vauthors = Yang YK, Thompson DA, Dickinson CJ, Wilken J, Barsh GS, Kent SB, Gantz I | title = Characterization of Agouti-related protein binding to melanocortin receptors | journal = Molecular Endocrinology | volume = 13 | issue = 1 | pages = 148–55 | date = January 1999 | pmid = 9892020 | doi = 10.1210/me.13.1.148 }}
*{{cite journal | author=Yang YK, Ollmann MM, Wilson BD, ''et al.'' |title=Effects of recombinant agouti-signaling protein on melanocortin action. |journal=Mol. Endocrinol. |volume=11 |issue= 3 |pages= 274-80 |year= 1997 |pmid= 9058374 |doi= }}
* {{cite journal | vauthors = Hatta N, Dixon C, Ray AJ, Phillips SR, Cunliffe WJ, Dale M, Todd C, Meggit S, Birch-MacHin MA, Rees JL | title = Expression, candidate gene, and population studies of the melanocortin 5 receptor | journal = The Journal of Investigative Dermatology | volume = 116 | issue = 4 | pages = 564–70 | date = April 2001 | pmid = 11286624 | doi = 10.1046/j.0022-202x.2001.01286.x }}
*{{cite journal | author=Frändberg PA, Xu X, Chhajlani V |title=Glutamine235 and arginine272 in human melanocortin 5 receptor determines its low affinity to MSH. |journal=Biochem. Biophys. Res. Commun. |volume=236 |issue= 2 |pages= 489-92 |year= 1997 |pmid= 9240466 |doi= 10.1006/bbrc.1997.6994 }}
* {{cite journal | vauthors = Bednarek MA, MacNeil T, Kalyani RN, Tang R, Van der Ploeg LH, Weinberg DH | title = Selective, high affinity peptide antagonists of alpha-melanotropin action at human melanocortin receptor 4: their synthesis and biological evaluation in vitro | journal = Journal of Medicinal Chemistry | volume = 44 | issue = 22 | pages = 3665–72 | date = October 2001 | pmid = 11606131 | doi = 10.1021/jm010165y }}
*{{cite journal | author=Yang YK, Thompson DA, Dickinson CJ, ''et al.'' |title=Characterization of Agouti-related protein binding to melanocortin receptors. |journal=Mol. Endocrinol. |volume=13 |issue= 1 |pages= 148-55 |year= 1999 |pmid= 9892020 |doi= }}
* {{cite journal | vauthors = Lapinsh M, Veiksina S, Uhlén S, Petrovska R, Mutule I, Mutulis F, Yahorava S, Prusis P, Wikberg JE | title = Proteochemometric mapping of the interaction of organic compounds with melanocortin receptor subtypes | journal = Molecular Pharmacology | volume = 67 | issue = 1 | pages = 50–9 | date = January 2005 | pmid = 15470082 | doi = 10.1124/mol.104.002857 }}
*{{cite journal | author=Hatta N, Dixon C, Ray AJ, ''et al.'' |title=Expression, candidate gene, and population studies of the melanocortin 5 receptor. |journal=J. Invest. Dermatol. |volume=116 |issue= 4 |pages= 564-70 |year= 2001 |pmid= 11286624 |doi= 10.1046/j.0022-202x.2001.01286.x }}
* {{cite journal | vauthors = Lohoff FW, Berrettini WH | title = Lack of association between variations in the melanocortin 5 receptor gene and bipolar disorder | journal = Psychiatric Genetics | volume = 15 | issue = 4 | pages = 255–8 | date = December 2005 | pmid = 16314755 | doi = 10.1097/00041444-200512000-00007 }}
*{{cite journal | author=Bednarek MA, MacNeil T, Kalyani RN, ''et al.'' |title=Selective, high affinity peptide antagonists of alpha-melanotropin action at human melanocortin receptor 4: their synthesis and biological evaluation in vitro. |journal=J. Med. Chem. |volume=44 |issue= 22 |pages= 3665-72 |year= 2001 |pmid= 11606131 |doi=  }}
* {{cite journal | vauthors = Grieco P, Cai M, Han G, Trivedi D, Campiglia P, Novellino E, Hruby VJ | title = Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5 | journal = Peptides | volume = 28 | issue = 6 | pages = 1191–6 | date = June 2007 | pmid = 17482720 | pmc = 1955225 | doi = 10.1016/j.peptides.2007.02.012 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Lapinsh M, Veiksina S, Uhlén S, ''et al.'' |title=Proteochemometric mapping of the interaction of organic compounds with melanocortin receptor subtypes. |journal=Mol. Pharmacol. |volume=67 |issue= 1 |pages= 50-9 |year= 2005 |pmid= 15470082 |doi= 10.1124/mol.104.002857 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Lohoff FW, Berrettini WH |title=Lack of association between variations in the melanocortin 5 receptor gene and bipolar disorder. |journal=Psychiatr. Genet. |volume=15 |issue= 4 |pages= 255-8 |year= 2006 |pmid= 16314755 |doi= }}
*{{cite journal | author=Grieco P, Cai M, Han G, ''et al.'' |title=Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. |journal=Peptides |volume=28 |issue= 6 |pages= 1191-6 |year= 2007 |pmid= 17482720 |doi= 10.1016/j.peptides.2007.02.012 }}
}}
{{refend}}
{{refend}}
== External links ==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2356 | title = Melanocortin Receptors: MC<sub>5</sub> | accessdate = | author = | authorlink = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = | quote = }}


{{NLM content}}
{{NLM content}}
{{membrane-protein-stub}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
{{Melanocortin receptor modulators}}
[[Category:G protein coupled receptors]]
[[Category:G protein coupled receptors]]
{{WikiDoc Sources}}
[[Category:Human proteins]]

Revision as of 16:41, 25 November 2017

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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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Ensembl

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RefSeq (mRNA)

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View/Edit Human

Melanocortin receptor 5 is a protein that in humans is encoded by the MC5R gene.[1][2] It is located on the chromosome 18 in the human genome.[2] When the melanocortin 5 receptor was disrupted in transgenic mice, it induced disruption of their exocrine glands and resulted in decreased production of sebum.[3]

Physiology

MC5R is necessary for normal sebum production.[3][4][5] Stimulation of MC5R promotes fatty acid oxidation in skeletal muscle[6] and lypolysis in adipocytes.[7] MC5R is essential for erythrocyte differentiation.[8] MC5R is involved in inflammation.[9][10] MC5R helps maintain thermal homeostasis.[4][11]

MC5R is expressed in the brain at different levels depending on physical activity.[12]

Pheromones

MC5R is heavily expressed in the preputial gland in mice (a modified sebaceous gland involved in pheromone production). MC5R deficiency in male mice decreases aggressive behavior, promotes defensive behavior and encourages other male mice to attack MC5R-deficient males through pheremonal signals.[13][14][15]

MRAP

Melanocortin 2 Receptor accessory protein (MRAP) traps MC5R protein inside cells.[16]

See also

References

  1. ↑ Chhajlani V, Muceniece R, Wikberg JE (September 1993). "Molecular cloning of a novel human melanocortin receptor". Biochemical and Biophysical Research Communications. 195 (2): 866–73. doi:10.1006/bbrc.1993.2125. PMID 8396929.
  2. ↑ 2.0 2.1 "Entrez Gene: MC5R melanocortin 5 receptor".
  3. ↑ 3.0 3.1 Thiboutot D, Sivarajah A, Gilliland K, Cong Z, Clawson G (October 2000). "The melanocortin 5 receptor is expressed in human sebaceous glands and rat preputial cells". The Journal of Investigative Dermatology. 115 (4): 614–9. doi:10.1046/j.1523-1747.2000.00094.x. PMID 10998132.
  4. ↑ 4.0 4.1 Chen W, Kelly MA, Opitz-Araya X, Thomas RE, Low MJ, Cone RD (December 1997). "Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides". Cell. 91 (6): 789–98. doi:10.1016/S0092-8674(00)80467-5. PMID 9413988.
  5. ↑ Zhang L, Li WH, Anthonavage M, Pappas A, Rossetti D, Cavender D, Seiberg M, Eisinger M (June 2011). "Melanocortin-5 receptor and sebogenesis". Eur J Pharmacol. 660 (1): 202–206. doi:10.1016/j.ejphar.2010.10.100. PMID 21215742.
  6. ↑ An JJ, Rhee Y, Kim SH, Kim DM, Han DH, Hwang JH, Jin YJ, Cha BS, Baik JH, Lee WT, Lim SK (February 2007). "Peripheral effect of alpha-melanocyte-stimulating hormone on fatty acid oxidation in skeletal muscle". The Journal of Biological Chemistry. 282 (5): 2862–70. doi:10.1074/jbc.M603454200. PMID 17127674.
  7. ↑ Møller CL, Raun K, Jacobsen ML, Pedersen TÅ, Holst B, Conde-Frieboes KW, Wulff BS (July 2011). "Characterization of murine melanocortin receptors mediating adipocyte lipolysis and examination of signalling pathways involved". Mol Cell Endocrinol. 341 (1–2): 9–17. doi:10.1016/j.mce.2011.03.010. PMID 21616121.
  8. ↑ Simamura E, Arikawa T, Ikeda T, Shimada H, Shoji H, Masuta H, Nakajima Y, Otani H, Yonekura H, Hatta T (April 2015). "Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5". PLOS ONE. 10 (4): e0123232. doi:10.1371/journal.pone.0123232. PMC 4393082. PMID 25860801.
  9. ↑ Lee DJ, Taylor AW (October 2013). "Both MC5r and A2Ar are required for protective regulatory immunity in the spleen of post-experimental autoimmune uveitis in mice". J. Immunol. 191 (8): 4103–4111. doi:10.4049/jimmunol.1300182. PMC 3796047. PMID 24043903.
  10. ↑ Jun DJ, Na KY, Kim W, Kwak D, Kwon EJ, Yoon JH, Yea K, Lee H, Kim J, Suh PG, Ryu SH, Kim KT (April 2010). "Melanocortins induce interleukin 6 gene expression and secretion through melanocortin receptors 2 and 5 in 3T3-L1 adipocytes". J Mol Endocrinol. 44 (4): 225–236. doi:10.1677/JME-09-0161. PMC 3058511. PMID 20089716.
  11. ↑ Lute B, Jou W, Lateef DM, Goldgof M, Xiao C, Piñol RA, Kravitz AV, Miller NR, Huang YG, Girardet C, Butler AA, Gavrilova O, Reitman ML (August 2014). "Biphasic effect of melanocortin agonists on metabolic rate and body temperature". Cell Metab. 20 (2): 333–345. doi:10.1016/j.cmet.2014.05.021. PMC 4126889. PMID 24981835.
  12. ↑ Shukla C, Britton SL, Koch LG, Novak CM (July 2012). "Region-specific differences in brain melanocortin receptors in rats of the lean phenotype". Neuroreport. 23 (10): 596–600. doi:10.1097/WNR.0b013e328354f5c1. PMC 3831884. PMID 22643233.
  13. ↑ Morgan C, Thomas RE, Cone RD (January 2004). "Melanocortin-5 receptor deficiency promotes defensive behavior in male mice". Horm Behav. 45 (1): 56–63. PMID 14733892.
  14. ↑ Morgan C, Thomas RE, Ma W, Novotny MV, Cone RD (February 2004). "Melanocortin-5 receptor deficiency reduces a pheromonal signal for aggression in male mice". Chem Senses. 29 (2): 111–115. doi:10.1093/chemse/bjh011. PMID 14977807.
  15. ↑ Morgan C, Cone RD (January 2006). "Melanocortin-5 receptor deficiency in mice blocks a novel pathway influencing pheromone-induced aggression". Behav Genet. 36 (2): 291–300. doi:10.1007/s10519-005-9024-9. PMID 16408249.
  16. ↑ Sebag JA, Hinkle PM (August 2009). "Opposite effects of the melanocortin-2 (MC2) receptor accessory protein MRAP on MC2 and MC5 receptor dimerization and trafficking". J Biol Chem. 284 (34): 22641–22648. doi:10.1074/jbc.M109.022400. PMC 2755671. PMID 19535343.

Further reading

  • Fathi Z, Iben LG, Parker EM (January 1995). "Cloning, expression, and tissue distribution of a fifth melanocortin receptor subtype". Neurochemical Research. 20 (1): 107–13. doi:10.1007/BF00995160. PMID 7739752.
  • Chowdhary BP, Gustavsson I, Wikberg JE, Chhajlani V (1994). "Localization of the human melanocortin-5 receptor gene (MC5R) to chromosome band 18p11.2 by fluorescence in situ hybridization". Cytogenetics and Cell Genetics. 68 (1–2): 79–81. doi:10.1159/000133895. PMID 7956366.
  • Griffon N, Mignon V, Facchinetti P, Diaz J, Schwartz JC, Sokoloff P (April 1994). "Molecular cloning and characterization of the rat fifth melanocortin receptor". Biochemical and Biophysical Research Communications. 200 (2): 1007–14. doi:10.1006/bbrc.1994.1550. PMID 8179577.
  • Gantz I, Shimoto Y, Konda Y, Miwa H, Dickinson CJ, Yamada T (May 1994). "Molecular cloning, expression, and characterization of a fifth melanocortin receptor". Biochemical and Biophysical Research Communications. 200 (3): 1214–20. doi:10.1006/bbrc.1994.1580. PMID 8185570.
  • Chhajlani V (February 1996). "Distribution of cDNA for melanocortin receptor subtypes in human tissues". Biochemistry and Molecular Biology International. 38 (1): 73–80. PMID 8932521.
  • Yang YK, Ollmann MM, Wilson BD, Dickinson C, Yamada T, Barsh GS, Gantz I (March 1997). "Effects of recombinant agouti-signaling protein on melanocortin action". Molecular Endocrinology. 11 (3): 274–80. doi:10.1210/me.11.3.274. PMID 9058374.
  • Frändberg PA, Xu X, Chhajlani V (July 1997). "Glutamine235 and arginine272 in human melanocortin 5 receptor determines its low affinity to MSH". Biochemical and Biophysical Research Communications. 236 (2): 489–92. doi:10.1006/bbrc.1997.6994. PMID 9240466.
  • Yang YK, Thompson DA, Dickinson CJ, Wilken J, Barsh GS, Kent SB, Gantz I (January 1999). "Characterization of Agouti-related protein binding to melanocortin receptors". Molecular Endocrinology. 13 (1): 148–55. doi:10.1210/me.13.1.148. PMID 9892020.
  • Hatta N, Dixon C, Ray AJ, Phillips SR, Cunliffe WJ, Dale M, Todd C, Meggit S, Birch-MacHin MA, Rees JL (April 2001). "Expression, candidate gene, and population studies of the melanocortin 5 receptor". The Journal of Investigative Dermatology. 116 (4): 564–70. doi:10.1046/j.0022-202x.2001.01286.x. PMID 11286624.
  • Bednarek MA, MacNeil T, Kalyani RN, Tang R, Van der Ploeg LH, Weinberg DH (October 2001). "Selective, high affinity peptide antagonists of alpha-melanotropin action at human melanocortin receptor 4: their synthesis and biological evaluation in vitro". Journal of Medicinal Chemistry. 44 (22): 3665–72. doi:10.1021/jm010165y. PMID 11606131.
  • Lapinsh M, Veiksina S, Uhlén S, Petrovska R, Mutule I, Mutulis F, Yahorava S, Prusis P, Wikberg JE (January 2005). "Proteochemometric mapping of the interaction of organic compounds with melanocortin receptor subtypes". Molecular Pharmacology. 67 (1): 50–9. doi:10.1124/mol.104.002857. PMID 15470082.
  • Lohoff FW, Berrettini WH (December 2005). "Lack of association between variations in the melanocortin 5 receptor gene and bipolar disorder". Psychiatric Genetics. 15 (4): 255–8. doi:10.1097/00041444-200512000-00007. PMID 16314755.
  • Grieco P, Cai M, Han G, Trivedi D, Campiglia P, Novellino E, Hruby VJ (June 2007). "Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5". Peptides. 28 (6): 1191–6. doi:10.1016/j.peptides.2007.02.012. PMC 1955225. PMID 17482720.

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