TNFRSF12A: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Tumor necrosis factor receptor superfamily member 12A''' also known as the '''TWEAK receptor''' ('''TWEAKR''') is a [[protein]] that in humans is encoded by the ''TNFRSF12A'' [[gene]].<ref name="pmid10751351">{{cite journal | vauthors = Feng SL, Guo Y, Factor VM, Thorgeirsson SS, Bell DW, Testa JR, Peifley KA, Winkles JA | title = The Fn14 Immediate-Early Response Gene Is Induced During Liver Regeneration and Highly Expressed in Both Human and Murine Hepatocellular Carcinomas | journal = Am J Pathol | volume = 156 | issue = 4 | pages = 1253–61 |date=Jun 2000 | pmid = 10751351 | pmc = 1876890 | doi =10.1016/S0002-9440(10)64996-6  }}</ref><ref name="pmid10551889">{{cite journal | vauthors = Meighan-Mantha RL, Hsu DK, Guo Y, Brown SA, Feng SL, Peifley KA, Alberts GF, Copeland NG, Gilbert DJ, Jenkins NA, Richards CM, Winkles JA | title = The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration | journal = J Biol Chem | volume = 274 | issue = 46 | pages = 33166–76 |date=Jan 2000 | pmid = 10551889 | pmc = | doi =10.1074/jbc.274.46.33166  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TNFRSF12A tumor necrosis factor receptor superfamily, member 12A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51330| accessdate = }}</ref>
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==Clinical significance==
{{GNF_Protein_box
[[NFAT1]] regulates the expression of TWEAKR (this protein) and its ligand [[TNFSF12|TWEAK]] with [[LCN2|lipocalin 2]] to increase breast cancer cell invasion.<ref name="pmid22767506">{{cite journal | vauthors = Gaudineau B, Fougère M, Guaddachi F, Lemoine F, de la Grange P, Jauliac S | title = Lipocalin 2, the TNF-like receptor TWEAKR and its ligand TWEAK act downstream of NFAT1 to regulate breast cancer cell invasion | journal = J. Cell Sci. | volume = 125 | issue = Pt 19 | pages = 4475–86 |date=October 2012 | pmid = 22767506 | doi = 10.1242/jcs.099879 }}</ref>
| image = 
| image_source =
| PDB =  
| Name = Tumor necrosis factor receptor superfamily, member 12A
| HGNCid = 18152
| Symbol = TNFRSF12A
| AltSymbols =; CD266; FN14; TWEAKR
| OMIM = 605914
| ECnumber = 
| Homologene = 8451
| MGIid = 1351484
| GeneAtlas_image1 = PBB_GE_TNFRSF12A_218368_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51330
    | Hs_Ensembl = ENSG00000006327
    | Hs_RefseqProtein = NP_057723
    | Hs_RefseqmRNA = NM_016639
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 3010343
    | Hs_GenLoc_end = 3012382
    | Hs_Uniprot = Q9NP84
    | Mm_EntrezGene = 27279
    | Mm_Ensembl = ENSMUSG00000023905
    | Mm_RefseqmRNA = NM_013749
    | Mm_RefseqProtein = NP_038777
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 23403063
    | Mm_GenLoc_end = 23405066
    | Mm_Uniprot = Q9CR75
  }}
}}
'''Tumor necrosis factor receptor superfamily, member 12A''', also known as '''TNFRSF12A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TNFRSF12A tumor necrosis factor receptor superfamily, member 12A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51330| accessdate = }}</ref>
 
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{{PBB_Summary
| section_title =
| summary_text =
}}


==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Campbell S, Michaelson J, Burkly L, Putterman C |title=The role of TWEAK/Fn14 in the pathogenesis of inflammation and systemic autoimmunity |journal=Front. Biosci. |volume=9 |issue=  |pages= 2273–84 |year= 2006 |pmid= 15353286 |doi=10.2741/1395 }}
| citations =
*{{cite journal   |vauthors=Wiley SR, Cassiano L, Lofton T, etal |title=A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis |journal=Immunity |volume=15 |issue= 5 |pages= 837–46 |year= 2001 |pmid= 11728344 |doi=10.1016/S1074-7613(01)00232-1 }}
*{{cite journal  | author=Campbell S, Michaelson J, Burkly L, Putterman C |title=The role of TWEAK/Fn14 in the pathogenesis of inflammation and systemic autoimmunity. |journal=Front. Biosci. |volume=9 |issue=  |pages= 2273-84 |year= 2006 |pmid= 15353286 |doi=  }}
*{{cite journal   |vauthors=Harada N, Nakayama M, Nakano H, etal |title=Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 3 |pages= 488–93 |year= 2003 |pmid= 12445828 |doi=10.1016/S0006-291X(02)02670-0 }}
*{{cite journal | author=Meighan-Mantha RL, Hsu DK, Guo Y, ''et al.'' |title=The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration. |journal=J. Biol. Chem. |volume=274 |issue= 46 |pages= 33166-76 |year= 2000 |pmid= 10551889 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Feng SL, Guo Y, Factor VM, ''et al.'' |title=The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas. |journal=Am. J. Pathol. |volume=156 |issue= 4 |pages= 1253-61 |year= 2000 |pmid= 10751351 |doi=  }}
*{{cite journal   |vauthors=Nakayama M, Ishidoh K, Kojima Y, etal |title=Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death |journal=J. Immunol. |volume=170 |issue= 1 |pages= 341–8 |year= 2003 |pmid= 12496418 |doi=  10.4049/jimmunol.170.1.341}}
*{{cite journal | author=Wiley SR, Cassiano L, Lofton T, ''et al.'' |title=A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis. |journal=Immunity |volume=15 |issue= 5 |pages= 837-46 |year= 2001 |pmid= 11728344 |doi=  }}
*{{cite journal   |vauthors=Tran NL, McDonough WS, Donohue PJ, etal |title=The Human Fn14 Receptor Gene Is Up-Regulated in Migrating Glioma Cells in Vitro and Overexpressed in Advanced Glial Tumors |journal=Am. J. Pathol. |volume=162 |issue= 4 |pages= 1313–21 |year= 2003 |pmid= 12651623 |doi= 10.1016/S0002-9440(10)63927-2| pmc=1851233  }}
*{{cite journal | author=Harada N, Nakayama M, Nakano H, ''et al.'' |title=Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells. |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 3 |pages= 488-93 |year= 2003 |pmid= 12445828 |doi=  }}
*{{cite journal  | vauthors=Tanabe K, Bonilla I, Winkles JA, Strittmatter SM |title=Fibroblast growth factor-inducible-14 is induced in axotomized neurons and promotes neurite outgrowth |journal=J. Neurosci. |volume=23 |issue= 29 |pages= 9675–86 |year= 2003 |pmid= 14573547 |doi=  }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Jin L, Nakao A, Nakayama M, etal |title=Induction of RANTES by TWEAK/Fn14 interaction in human keratinocytes |journal=J. Invest. Dermatol. |volume=122 |issue= 5 |pages= 1175–9 |year= 2004 |pmid= 15140220 |doi= 10.1111/j.0022-202X.2004.22419.x }}
*{{cite journal  | author=Nakayama M, Ishidoh K, Kojima Y, ''et al.'' |title=Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death. |journal=J. Immunol. |volume=170 |issue= 1 |pages= 341-8 |year= 2003 |pmid= 12496418 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Tran NL, McDonough WS, Donohue PJ, ''et al.'' |title=The human Fn14 receptor gene is up-regulated in migrating glioma cells in vitro and overexpressed in advanced glial tumors. |journal=Am. J. Pathol. |volume=162 |issue= 4 |pages= 1313-21 |year= 2003 |pmid= 12651623 |doi= }}
*{{cite journal   |vauthors=Tran NL, McDonough WS, Savitch BA, etal |title=The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling system regulates glioma cell survival via NFkappaB pathway activation and BCL-XL/BCL-W expression |journal=J. Biol. Chem. |volume=280 |issue= 5 |pages= 3483–92 |year= 2005 |pmid= 15611130 |doi= 10.1074/jbc.M409906200 }}
*{{cite journal | author=Tanabe K, Bonilla I, Winkles JA, Strittmatter SM |title=Fibroblast growth factor-inducible-14 is induced in axotomized neurons and promotes neurite outgrowth. |journal=J. Neurosci. |volume=23 |issue= 29 |pages= 9675-86 |year= 2003 |pmid= 14573547 |doi= }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Jin L, Nakao A, Nakayama M, ''et al.'' |title=Induction of RANTES by TWEAK/Fn14 interaction in human keratinocytes. |journal=J. Invest. Dermatol. |volume=122 |issue= 5 |pages= 1175-9 |year= 2004 |pmid= 15140220 |doi= 10.1111/j.0022-202X.2004.22419.x }}
*{{cite journal   |vauthors=Chacón MR, Richart C, Gómez JM, etal |title=Expression of TWEAK and its receptor Fn14 in human subcutaneous adipose tissue. Relationship with other inflammatory cytokines in obesity |journal=Cytokine |volume=33 |issue= 3 |pages= 129–37 |year= 2006 |pmid= 16503147 |doi= 10.1016/j.cyto.2005.12.005 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Brown SA, Hanscom HN, Vu H, etal |title=TWEAK binding to the Fn14 cysteine-rich domain depends on charged residues located in both the A1 and D2 modules |journal=Biochem. J. |volume=397 |issue= 2 |pages= 297–304 |year= 2006 |pmid= 16526941 |doi= 10.1042/BJ20051362  | pmc=1513280 }}
*{{cite journal | author=Tran NL, McDonough WS, Savitch BA, ''et al.'' |title=The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling system regulates glioma cell survival via NFkappaB pathway activation and BCL-XL/BCL-W expression. |journal=J. Biol. Chem. |volume=280 |issue= 5 |pages= 3483-92 |year= 2005 |pmid= 15611130 |doi= 10.1074/jbc.M409906200 }}
*{{cite journal   |vauthors=Muñoz-García B, Martín-Ventura JL, Martínez E, etal |title=Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques: modulation by atorvastatin |journal=Stroke |volume=37 |issue= 8 |pages= 2044–53 |year= 2006 |pmid= 16809572 |doi= 10.1161/01.STR.0000230648.00027.00 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Tran NL, McDonough WS, Savitch BA, etal |title=Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome |journal=Cancer Res. |volume=66 |issue= 19 |pages= 9535–42 |year= 2007 |pmid= 17018610 |doi= 10.1158/0008-5472.CAN-06-0418 }}
*{{cite journal | author=Chacón MR, Richart C, Gómez JM, ''et al.'' |title=Expression of TWEAK and its receptor Fn14 in human subcutaneous adipose tissue. Relationship with other inflammatory cytokines in obesity. |journal=Cytokine |volume=33 |issue= 3 |pages= 129-37 |year= 2006 |pmid= 16503147 |doi= 10.1016/j.cyto.2005.12.005 }}
*{{cite journal   |vauthors=Girgenrath M, Weng S, Kostek CA, etal |title=TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration |journal=EMBO J. |volume=25 |issue= 24 |pages= 5826–39 |year= 2007 |pmid= 17124496 |doi= 10.1038/sj.emboj.7601441 | pmc=1698888 }}
*{{cite journal | author=Brown SA, Hanscom HN, Vu H, ''et al.'' |title=TWEAK binding to the Fn14 cysteine-rich domain depends on charged residues located in both the A1 and D2 modules. |journal=Biochem. J. |volume=397 |issue= 2 |pages= 297-304 |year= 2006 |pmid= 16526941 |doi= 10.1042/BJ20051362 }}
*{{cite journal   |vauthors=Dogra C, Hall SL, Wedhas N, etal |title=Fibroblast growth factor inducible 14 (Fn14) is required for the expression of myogenic regulatory factors and differentiation of myoblasts into myotubes. Evidence for TWEAK-independent functions of Fn14 during myogenesis |journal=J. Biol. Chem. |volume=282 |issue= 20 |pages= 15000–10 |year= 2007 |pmid= 17383968 |doi= 10.1074/jbc.M608668200 }}
*{{cite journal | author=Muñoz-García B, Martín-Ventura JL, Martínez E, ''et al.'' |title=Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques: modulation by atorvastatin. |journal=Stroke |volume=37 |issue= 8 |pages= 2044-53 |year= 2006 |pmid= 16809572 |doi= 10.1161/01.STR.0000230648.00027.00 }}
*{{cite journal | author=Tran NL, McDonough WS, Savitch BA, ''et al.'' |title=Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome. |journal=Cancer Res. |volume=66 |issue= 19 |pages= 9535-42 |year= 2007 |pmid= 17018610 |doi= 10.1158/0008-5472.CAN-06-0418 }}
*{{cite journal  | author=Girgenrath M, Weng S, Kostek CA, ''et al.'' |title=TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration. |journal=EMBO J. |volume=25 |issue= 24 |pages= 5826-39 |year= 2007 |pmid= 17124496 |doi= 10.1038/sj.emboj.7601441 }}
*{{cite journal | author=Dogra C, Hall SL, Wedhas N, ''et al.'' |title=Fibroblast growth factor inducible 14 (Fn14) is required for the expression of myogenic regulatory factors and differentiation of myoblasts into myotubes. Evidence for TWEAK-independent functions of Fn14 during myogenesis. |journal=J. Biol. Chem. |volume=282 |issue= 20 |pages= 15000-10 |year= 2007 |pmid= 17383968 |doi= 10.1074/jbc.M608668200 }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Clusters of differentiation}}
{{Clusters of differentiation}}
{{Tumor necrosis factor receptor superfamily}}
{{Tumor necrosis factor receptor superfamily}}
{{Cytokine receptor modulators}}
[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
[[Category:Cytokine receptors]]
[[Category:TNF receptor family]]
{{WikiDoc Sources}}
 
 
{{membrane-protein-stub}}

Revision as of 21:01, 8 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Tumor necrosis factor receptor superfamily member 12A also known as the TWEAK receptor (TWEAKR) is a protein that in humans is encoded by the TNFRSF12A gene.[1][2][3]

Clinical significance

NFAT1 regulates the expression of TWEAKR (this protein) and its ligand TWEAK with lipocalin 2 to increase breast cancer cell invasion.[4]

References

  1. ↑ Feng SL, Guo Y, Factor VM, Thorgeirsson SS, Bell DW, Testa JR, Peifley KA, Winkles JA (Jun 2000). "The Fn14 Immediate-Early Response Gene Is Induced During Liver Regeneration and Highly Expressed in Both Human and Murine Hepatocellular Carcinomas". Am J Pathol. 156 (4): 1253–61. doi:10.1016/S0002-9440(10)64996-6. PMC 1876890. PMID 10751351.
  2. ↑ Meighan-Mantha RL, Hsu DK, Guo Y, Brown SA, Feng SL, Peifley KA, Alberts GF, Copeland NG, Gilbert DJ, Jenkins NA, Richards CM, Winkles JA (Jan 2000). "The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration". J Biol Chem. 274 (46): 33166–76. doi:10.1074/jbc.274.46.33166. PMID 10551889.
  3. ↑ "Entrez Gene: TNFRSF12A tumor necrosis factor receptor superfamily, member 12A".
  4. ↑ Gaudineau B, Fougère M, Guaddachi F, Lemoine F, de la Grange P, Jauliac S (October 2012). "Lipocalin 2, the TNF-like receptor TWEAKR and its ligand TWEAK act downstream of NFAT1 to regulate breast cancer cell invasion". J. Cell Sci. 125 (Pt 19): 4475–86. doi:10.1242/jcs.099879. PMID 22767506.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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