Tachykinin receptor 3: Difference between revisions

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Revision as of 00:57, 27 October 2017

Tachykinin receptor 3, also known as TACR3, is a protein which in humans is encoded by the TACR3 gene.^[1]^[2]

Function

This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B.^[2]

Selective ligands

A number of selective ligands are available for NK₃. NK₃ receptor antagonists are being investigated as treatments for various indications.^[3]

Agonists

Neurokinin B – endogenous peptide ligand, also interacts with other neurokinin receptors but has highest affinity for NK₃
Senktide – 7-amino acid polypeptide, NK₃ selective, CAS# 106128-89-6

Antagonists

Fezolinetant (ESN-364)
MLE-4901 (also known as AZD-4901, formerly AZD-2624)
Osanetant (SR-142,801)
Talnetant (SB-223,412)
SB-222,200 – potent and selective antagonist, K_i = 4.4 nM, 3-Methyl-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide, CAS# 174635-69-9
SB-218,795 – more selective than SB-222,200, K_i = 13 nM, (R)-[(2-Phenyl-4-quinolinylcarbonyl)amino]-methyl ester benzeneacetic acid, CAS# 174635-53-1

References

↑ Huang RR, Cheung AH, Mazina KE, Strader CD, Fong TM (Apr 1992). "cDNA sequence and heterologous expression of the human neurokinin-3 receptor". Biochemical and Biophysical Research Communications. 184 (2): 966–72. doi:10.1016/0006-291X(92)90685-E. PMID 1374246.
↑ ^2.0 ^2.1 "Entrez Gene: TACR3 tachykinin receptor 3".
↑ Quartara L, Altamura M (Aug 2006). "Tachykinin receptors antagonists: from research to clinic". Current Drug Targets. 7 (8): 975–92. doi:10.2174/138945006778019381. PMID 16918326.

Khawaja AM, Rogers DF (Jul 1996). "Tachykinins: receptor to effector". The International Journal of Biochemistry & Cell Biology. 28 (7): 721–38. doi:10.1016/1357-2725(96)00017-9. PMID 8925404.
Advenier C, Lagente V, Boichot E (Aug 1997). "The role of tachykinin receptor antagonists in the prevention of bronchial hyperresponsiveness, airway inflammation and cough". The European Respiratory Journal. 10 (8): 1892–906. doi:10.1183/09031936.97.10081892. PMID 9272936.
Buell G, Schulz MF, Arkinstall SJ, Maury K, Missotten M, Adami N, Talabot F, Kawashima E (Mar 1992). "Molecular characterisation, expression and localisation of human neurokinin-3 receptor". FEBS Letters. 299 (1): 90–5. doi:10.1016/0014-5793(92)80107-R. PMID 1312036.
Takahashi K, Tanaka A, Hara M, Nakanishi S (Mar 1992). "The primary structure and gene organization of human substance P and neuromedin K receptors". European Journal of Biochemistry / FEBS. 204 (3): 1025–33. doi:10.1111/j.1432-1033.1992.tb16724.x. PMID 1312928.
Xie GX, Miyajima A, Goldstein A (May 1992). "Expression cloning of cDNA encoding a seven-helix receptor from human placenta with affinity for opioid ligands". Proceedings of the National Academy of Sciences of the United States of America. 89 (9): 4124–8. doi:10.1073/pnas.89.9.4124. PMC 525645. PMID 1315051.
Huang RR, Cheung AH, Mazina KE, Strader CD, Fong TM (Apr 1992). "cDNA sequence and heterologous expression of the human neurokinin-3 receptor". Biochemical and Biophysical Research Communications. 184 (2): 966–72. doi:10.1016/0006-291X(92)90685-E. PMID 1374246.
Dion S, Corcos J, Carmel M, Drapeau G, Regoli D (1988). "Substance P and neurokinins as stimulants of the human isolated urinary bladder". Neuropeptides. 11 (2): 83–7. doi:10.1016/0143-4179(88)90015-7. PMID 2452993.
Krause JE, Staveteig PT, Mentzer JN, Schmidt SK, Tucker JB, Brodbeck RM, Bu JY, Karpitskiy VV (Jan 1997). "Functional expression of a novel human neurokinin-3 receptor homolog that binds [3H]senktide and [125I-MePhe7]neurokinin B, and is responsive to tachykinin peptide agonists". Proceedings of the National Academy of Sciences of the United States of America. 94 (1): 310–5. doi:10.1073/pnas.94.1.310. PMC 19326. PMID 8990205.
Brunelleschi S, Bordin G, Colangelo D, Viano I (Jun 1998). "Tachykinin receptors on human monocytes: their involvement in rheumatoid arthritis". Neuropeptides. 32 (3): 215–23. doi:10.1016/S0143-4179(98)90040-3. PMID 10189055.
Page NM, Woods RJ, Gardiner SM, Lomthaisong K, Gladwell RT, Butlin DJ, Manyonda IT, Lowry PJ (Jun 2000). "Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia". Nature. 405 (6788): 797–800. doi:10.1038/35015579. PMID 10866201.
Bellucci F, Carini F, Catalani C, Cucchi P, Lecci A, Meini S, Patacchini R, Quartara L, Ricci R, Tramontana M, Giuliani S, Maggi CA (Jan 2002). "Pharmacological profile of the novel mammalian tachykinin, hemokinin 1". British Journal of Pharmacology. 135 (1): 266–74. doi:10.1038/sj.bjp.0704443. PMC 1573107. PMID 11786503.
Graham GJ, Stevens JM, Page NM, Grant AD, Brain SD, Lowry PJ, Gibbins JM (Aug 2004). "Tachykinins regulate the function of platelets". Blood. 104 (4): 1058–65. doi:10.1182/blood-2003-11-3979. PMID 15130944.
Page NM, Dakour J, Morrish DW (Jul 2006). "Gene regulation of neurokinin B and its receptor NK3 in late pregnancy and pre-eclampsia". Molecular Human Reproduction. 12 (7): 427–33. doi:10.1093/molehr/gal025. PMID 16709596.

External links

"Tachykinin Receptors: NK₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

[pmid1374246-1] Huang RR, Cheung AH, Mazina KE, Strader CD, Fong TM (Apr 1992). "cDNA sequence and heterologous expression of the human neurokinin-3 receptor". Biochemical and Biophysical Research Communications. 184 (2): 966–72. doi:10.1016/0006-291X(92)90685-E. PMID 1374246.

[entrez-2] 2.0 ^2.1 "Entrez Gene: TACR3 tachykinin receptor 3".

[pmid16918326-3] Quartara L, Altamura M (Aug 2006). "Tachykinin receptors antagonists: from research to clinic". Current Drug Targets. 7 (8): 975–92. doi:10.2174/138945006778019381. PMID 16918326.

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
+{{Infobox_gene}}
+'''Tachykinin receptor 3''', also known as '''TACR3''', is a [[protein]] which in humans is encoded by the ''TACR3'' [[gene]].<ref name="pmid1374246">{{cite journal | vauthors = Huang RR, Cheung AH, Mazina KE, Strader CD, Fong TM | title = cDNA sequence and heterologous expression of the human neurokinin-3 receptor | journal = Biochemical and Biophysical Research Communications | volume = 184 | issue = 2 | pages = 966–72 | date = Apr 1992 | pmid = 1374246 | doi = 10.1016/0006-291X(92)90685-E }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TACR3 tachykinin receptor 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6870| accessdate = }}</ref>
+== Function ==
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+This gene belongs to a family of genes that function as [[receptor (biochemistry)|receptor]]s for [[tachykinin]]s.  Receptor affinities are specified by variations in the 5'-end of the sequence.  The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions.  This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as [[neurokinin B]].<ref name="entrez" />
-{{PBB_Controls
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Selective ligands ==
-{{GNF_Protein_box
+A number of selective ligands are available for NK<sub>3</sub>. NK<sub>3</sub> receptor antagonists are being investigated as treatments for various indications.<ref name="pmid16918326">{{cite journal | vauthors = Quartara L, Altamura M | title = Tachykinin receptors antagonists: from research to clinic | journal = Current Drug Targets | volume = 7 | issue = 8 | pages = 975–92 | date = Aug 2006 | pmid = 16918326 | doi = 10.2174/138945006778019381 }}</ref>
- | image =
- | image_source =
- | PDB =
- | Name = Tachykinin receptor 3
- | HGNCid = 11528
- | Symbol = TACR3
- | AltSymbols =; MGC148060; MGC148061; NK3R; TAC3RL
- | OMIM = 162332
- | ECnumber =
- | Homologene = 824
- | MGIid = 892968
- | GeneAtlas_image1 = PBB_GE_TACR3_208183_at_tn.png
- | Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004995 |text = tachykinin receptor activity}}
- | Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
- | Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007217 |text = tachykinin signaling pathway}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 6870
-    | Hs_Ensembl = ENSG00000169836
-    | Hs_RefseqProtein = NP_001050
-    | Hs_RefseqmRNA = NM_001059
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 4
-    | Hs_GenLoc_start = 104730074
-    | Hs_GenLoc_end = 104860422
-    | Hs_Uniprot = P29371
-    | Mm_EntrezGene = 21338
-    | Mm_Ensembl = ENSMUSG00000028172
-    | Mm_RefseqmRNA = NM_021382
-    | Mm_RefseqProtein = NP_067357
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 3
-    | Mm_GenLoc_start = 134766394
-    | Mm_GenLoc_end = 134871959
-    | Mm_Uniprot = Q6NXX1
-  }}
-}}
-'''Tachykinin receptor 3''', also known as '''TACR3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TACR3 tachykinin receptor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6870| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+=== Agonists ===
-{{PBB_Summary
+* [[Neurokinin B]] – endogenous peptide ligand, also interacts with other neurokinin receptors but has highest affinity for NK<sub>3</sub>
-| section_title =
+* [[Senktide]] – 7-amino acid polypeptide, NK<sub>3</sub> selective, CAS# 106128-89-6
-| summary_text = This gene belongs to a family of genes that function as receptors for tachykinins.  Receptor affinities are specified by variations in the 5'-end of the sequence.  The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions.  This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B.<ref name="entrez">{{cite web | title = Entrez Gene: TACR3 tachykinin receptor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6870| accessdate = }}</ref>
-}}
-==See also==
+=== Antagonists ===
+* [[Fezolinetant]] (ESN-364)
+* [[MLE-4901]] (also known as AZD-4901, formerly AZD-2624)
+* [[Osanetant]] (SR-142,801)
+* [[Talnetant]] (SB-223,412)
+* [[SB-222,200]] – potent and selective antagonist, K<sub>i</sub> = 4.4 nM, 3-Methyl-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide, CAS# 174635-69-9
+* [[SB-218,795]] – more selective than SB-222,200, K<sub>i</sub> = 13 nM, (R)-[(2-Phenyl-4-quinolinylcarbonyl)amino]-methyl ester benzeneacetic acid, CAS# 174635-53-1
+== See also ==
 * [[Tachykinin receptor]]
-==References==
+== References ==
-{{reflist|2}}
+{{reflist|35em}}
-==Further reading==
+== Further reading ==
-{{refbegin | 2}}
+{{refbegin|35em}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Khawaja AM, Rogers DF | title = Tachykinins: receptor to effector | journal = The International Journal of Biochemistry & Cell Biology | volume = 28 | issue = 7 | pages = 721–38 | date = Jul 1996 | pmid = 8925404 | doi = 10.1016/1357-2725(96)00017-9 }}
-| citations =
+* {{cite journal | vauthors = Advenier C, Lagente V, Boichot E | title = The role of tachykinin receptor antagonists in the prevention of bronchial hyperresponsiveness, airway inflammation and cough | journal = The European Respiratory Journal | volume = 10 | issue = 8 | pages = 1892–906 | date = Aug 1997 | pmid = 9272936 | doi = 10.1183/09031936.97.10081892 }}
-*{{cite journal  | author=Khawaja AM, Rogers DF |title=Tachykinins: receptor to effector. |journal=Int. J. Biochem. Cell Biol. |volume=28 |issue= 7 |pages= 721-38 |year= 1996 |pmid= 8925404 |doi=  }}
+* {{cite journal | vauthors = Buell G, Schulz MF, Arkinstall SJ, Maury K, Missotten M, Adami N, Talabot F, Kawashima E | title = Molecular characterisation, expression and localisation of human neurokinin-3 receptor | journal = FEBS Letters | volume = 299 | issue = 1 | pages = 90–5 | date = Mar 1992 | pmid = 1312036 | doi = 10.1016/0014-5793(92)80107-R }}
-*{{cite journal  | author=Advenier C, Lagente V, Boichot E |title=The role of tachykinin receptor antagonists in the prevention of bronchial hyperresponsiveness, airway inflammation and cough. |journal=Eur. Respir. J. |volume=10 |issue= 8 |pages= 1892-906 |year= 1997 |pmid= 9272936 |doi=  }}
+* {{cite journal | vauthors = Takahashi K, Tanaka A, Hara M, Nakanishi S | title = The primary structure and gene organization of human substance P and neuromedin K receptors | journal = European Journal of Biochemistry / FEBS | volume = 204 | issue = 3 | pages = 1025–33 | date = Mar 1992 | pmid = 1312928 | doi = 10.1111/j.1432-1033.1992.tb16724.x }}
-*{{cite journal  | author=Buell G, Schulz MF, Arkinstall SJ, ''et al.'' |title=Molecular characterisation, expression and localisation of human neurokinin-3 receptor. |journal=FEBS Lett. |volume=299 |issue= 1 |pages= 90-5 |year= 1992 |pmid= 1312036 |doi=  }}
+* {{cite journal | vauthors = Xie GX, Miyajima A, Goldstein A | title = Expression cloning of cDNA encoding a seven-helix receptor from human placenta with affinity for opioid ligands | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 89 | issue = 9 | pages = 4124–8 | date = May 1992 | pmid = 1315051 | pmc = 525645 | doi = 10.1073/pnas.89.9.4124 }}
-*{{cite journal  | author=Takahashi K, Tanaka A, Hara M, Nakanishi S |title=The primary structure and gene organization of human substance P and neuromedin K receptors. |journal=Eur. J. Biochem. |volume=204 |issue= 3 |pages= 1025-33 |year= 1992 |pmid= 1312928 |doi=  }}
+* {{cite journal | vauthors = Huang RR, Cheung AH, Mazina KE, Strader CD, Fong TM | title = cDNA sequence and heterologous expression of the human neurokinin-3 receptor | journal = Biochemical and Biophysical Research Communications | volume = 184 | issue = 2 | pages = 966–72 | date = Apr 1992 | pmid = 1374246 | doi = 10.1016/0006-291X(92)90685-E }}
-*{{cite journal  | author=Xie GX, Miyajima A, Goldstein A |title=Expression cloning of cDNA encoding a seven-helix receptor from human placenta with affinity for opioid ligands. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 9 |pages= 4124-8 |year= 1992 |pmid= 1315051 |doi=  }}
+* {{cite journal | vauthors = Dion S, Corcos J, Carmel M, Drapeau G, Regoli D | title = Substance P and neurokinins as stimulants of the human isolated urinary bladder | journal = Neuropeptides | volume = 11 | issue = 2 | pages = 83–7 | year = 1988 | pmid = 2452993 | doi = 10.1016/0143-4179(88)90015-7 }}
-*{{cite journal  | author=Huang RR, Cheung AH, Mazina KE, ''et al.'' |title=cDNA sequence and heterologous expression of the human neurokinin-3 receptor. |journal=Biochem. Biophys. Res. Commun. |volume=184 |issue= 2 |pages= 966-72 |year= 1992 |pmid= 1374246 |doi=  }}
+* {{cite journal | vauthors = Krause JE, Staveteig PT, Mentzer JN, Schmidt SK, Tucker JB, Brodbeck RM, Bu JY, Karpitskiy VV | title = Functional expression of a novel human neurokinin-3 receptor homolog that binds [3H]senktide and [125I-MePhe7]neurokinin B, and is responsive to tachykinin peptide agonists | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 1 | pages = 310–5 | date = Jan 1997 | pmid = 8990205 | pmc = 19326 | doi = 10.1073/pnas.94.1.310 }}
-*{{cite journal  | author=Dion S, Corcos J, Carmel M, ''et al.'' |title=Substance P and neurokinins as stimulants of the human isolated urinary bladder. |journal=Neuropeptides |volume=11 |issue= 2 |pages= 83-7 |year= 1988 |pmid= 2452993 |doi=  }}
+* {{cite journal | vauthors = Brunelleschi S, Bordin G, Colangelo D, Viano I | title = Tachykinin receptors on human monocytes: their involvement in rheumatoid arthritis | journal = Neuropeptides | volume = 32 | issue = 3 | pages = 215–23 | date = Jun 1998 | pmid = 10189055 | doi = 10.1016/S0143-4179(98)90040-3 }}
-*{{cite journal  | author=Krause JE, Staveteig PT, Mentzer JN, ''et al.'' |title=Functional expression of a novel human neurokinin-3 receptor homolog that binds [3H]senktide and [125I-MePhe7]neurokinin B, and is responsive to tachykinin peptide agonists. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 1 |pages= 310-5 |year= 1997 |pmid= 8990205 |doi=  }}
+* {{cite journal | vauthors = Page NM, Woods RJ, Gardiner SM, Lomthaisong K, Gladwell RT, Butlin DJ, Manyonda IT, Lowry PJ | title = Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia | journal = Nature | volume = 405 | issue = 6788 | pages = 797–800 | date = Jun 2000 | pmid = 10866201 | doi = 10.1038/35015579 }}
-*{{cite journal  | author=Brunelleschi S, Bordin G, Colangelo D, Viano I |title=Tachykinin receptors on human monocytes: their involvement in rheumatoid arthritis. |journal=Neuropeptides |volume=32 |issue= 3 |pages= 215-23 |year= 1999 |pmid= 10189055 |doi=  }}
+* {{cite journal | vauthors = Bellucci F, Carini F, Catalani C, Cucchi P, Lecci A, Meini S, Patacchini R, Quartara L, Ricci R, Tramontana M, Giuliani S, Maggi CA | title = Pharmacological profile of the novel mammalian tachykinin, hemokinin 1 | journal = British Journal of Pharmacology | volume = 135 | issue = 1 | pages = 266–74 | date = Jan 2002 | pmid = 11786503 | pmc = 1573107 | doi = 10.1038/sj.bjp.0704443 }}
-*{{cite journal  | author=Page NM, Woods RJ, Gardiner SM, ''et al.'' |title=Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia. |journal=Nature |volume=405 |issue= 6788 |pages= 797-800 |year= 2000 |pmid= 10866201 |doi= 10.1038/35015579 }}
+* {{cite journal | vauthors = Graham GJ, Stevens JM, Page NM, Grant AD, Brain SD, Lowry PJ, Gibbins JM | title = Tachykinins regulate the function of platelets | journal = Blood | volume = 104 | issue = 4 | pages = 1058–65 | date = Aug 2004 | pmid = 15130944 | doi = 10.1182/blood-2003-11-3979 }}
-*{{cite journal  | author=Bellucci F, Carini F, Catalani C, ''et al.'' |title=Pharmacological profile of the novel mammalian tachykinin, hemokinin 1. |journal=Br. J. Pharmacol. |volume=135 |issue= 1 |pages= 266-74 |year= 2002 |pmid= 11786503 |doi= 10.1038/sj.bjp.0704443 }}
+* {{cite journal | vauthors = Page NM, Dakour J, Morrish DW | title = Gene regulation of neurokinin B and its receptor NK3 in late pregnancy and pre-eclampsia | journal = Molecular Human Reproduction | volume = 12 | issue = 7 | pages = 427–33 | date = Jul 2006 | pmid = 16709596 | doi = 10.1093/molehr/gal025 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
-*{{cite journal  | author=Graham GJ, Stevens JM, Page NM, ''et al.'' |title=Tachykinins regulate the function of platelets. |journal=Blood |volume=104 |issue= 4 |pages= 1058-65 |year= 2005 |pmid= 15130944 |doi= 10.1182/blood-2003-11-3979 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-*{{cite journal  | author=Page NM, Dakour J, Morrish DW |title=Gene regulation of neurokinin B and its receptor NK3 in late pregnancy and pre-eclampsia. |journal=Mol. Hum. Reprod. |volume=12 |issue= 7 |pages= 427-33 |year= 2006 |pmid= 16709596 |doi= 10.1093/molehr/gal025 }}
-}}
 {{refend}}
+== External links ==
+* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3031 | title = Tachykinin Receptors: NK<sub>3</sub> | accessdate = | author = | authorlink = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = | quote = }}
 {{NLM content}}
 {{G protein-coupled receptors}}
+{{Neurokinin receptor modulators}}
 [[Category:G protein coupled receptors]]
-{{WH}}
-{{WS}}
+{{transmembranereceptor-stub}}

v t e Neurokinin receptor modulators
NK₁	Agonists: Substance P Antagonists: Aprepitant Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117 L-733,060 L-741,671 L-743,310 L-758,298 Lanepitant LY-306740 Maropitant Netupitant NKP-608 Nolpitantium besilate Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant
NK₂	Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant
NK₃	Agonists: Neurokinin B Senktide Antagonists: Fezolinetant (ESN-364) Osanetant (SR-142,801) Pavinetant (MLE-4901, AZD-2624, AZD-4901) SB-218,795 SB-222,200 Talnetant (SB-223,412)
See also: Receptor/signaling modulators • Signaling peptide/protein receptor modulators

Tachykinin receptor 3: Difference between revisions

Revision as of 00:57, 27 October 2017

Contents

Function

Selective ligands

Agonists

Antagonists

See also

References

Further reading

External links

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