CD137

tumor necrosis factor receptor superfamily, member 9
Identifiers
Symbol	TNFRSF9
Alt. symbols	ILA, CD137
Entrez	3604
HUGO	11924
OMIM	602250
RefSeq	NM_001561
UniProt	Q07011
Other data
Locus	Chr. 1 p36

WikiDoc Resources for CD137
Articles
Most recent articles on CD137 Most cited articles on CD137 Review articles on CD137 Articles on CD137 in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on CD137 Images of CD137 Photos of CD137 Podcasts & MP3s on CD137 Videos on CD137
Evidence Based Medicine
Cochrane Collaboration on CD137 Bandolier on CD137 TRIP on CD137
Clinical Trials
Ongoing Trials on CD137 at Clinical Trials.gov Trial results on CD137 Clinical Trials on CD137 at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on CD137 NICE Guidance on CD137 NHS PRODIGY Guidance FDA on CD137 CDC on CD137
Books
Books on CD137
News
CD137 in the news Be alerted to news on CD137 News trends on CD137
Commentary
Blogs on CD137
Definitions
Definitions of CD137
Patient Resources / Community
Patient resources on CD137 Discussion groups on CD137 Patient Handouts on CD137 Directions to Hospitals Treating CD137 Risk calculators and risk factors for CD137
Healthcare Provider Resources
Symptoms of CD137 Causes & Risk Factors for CD137 Diagnostic studies for CD137 Treatment of CD137
Continuing Medical Education (CME)
CME Programs on CD137
International
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Business
CD137 in the Marketplace Patents on CD137
Experimental / Informatics
List of terms related to CD137

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

CD137 is a member of the tumor necrosis factor (TNF) receptor family. Its alternative names are 4-1BB and induced by lymphocyte activation (ILA).

Expression

CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation.

Specific effects on cells

The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferatuon, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice.

Related chapters

• 4-1BB ligand

References

• Kwon BS, Weissman SM (1989). "cDNA sequences of two inducible T-cell genes". Proc. Natl. Acad. Sci. U.S.A. 86 (6): 1963–7. PMID 2784565.

• Schwarz H, Tuckwell J, Lotz M (1993). "A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family". Gene. 134 (2): 295–8. PMID 8262389.CS1 maint: Multiple names: authors list (link)

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