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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Opsin-3''' also known as '''encephalopsin''' or '''panopsin'''<ref name="KoyanagiTakada2013">{{cite journal | vauthors = Koyanagi M, Takada E, Nagata T, Tsukamoto H, Terakita A | title = Homologs of vertebrate Opn3 potentially serve as a light sensor in nonphotoreceptive tissue | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 110 | issue = 13 | pages = 4998–5003 | date = Mar 2013 | pmid = 23479626 | doi = 10.1073/pnas.1219416110 | url = http://www.pnas.org/content/110/13/4998.full | pmc=3612648}}</ref> is a [[protein]] that, in humans, is encoded by the ''OPN3'' [[gene]].<ref name="pmid10234000">{{cite journal | vauthors = Blackshaw S, Snyder SH | title = Encephalopsin: a novel mammalian extraretinal opsin discretely localized in the brain | journal = The Journal of Neuroscience | volume = 19 | issue = 10 | pages = 3681–90 | date = May 1999 | pmid = 10234000 | pmc =  | doi =  }}</ref><ref name="pmid11401433">{{cite journal | vauthors = Halford S, Freedman MS, Bellingham J, Inglis SL, Poopalasundaram S, Soni BG, Foster RG, Hunt DM | title = Characterization of a novel human opsin gene with wide tissue expression and identification of embedded and flanking genes on chromosome 1q43 | journal = Genomics | volume = 72 | issue = 2 | pages = 203–8 | date = Mar 2001 | pmid = 11401433 | pmc =  | doi = 10.1006/geno.2001.6469 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: OPN3 opsin 3 (encephalopsin, panopsin)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23596| accessdate = }}</ref> [[Alternative splicing]] of this gene results in multiple [[transcription (genetics)|transcript]] variants encoding different [[protein isoform]]s.<ref name=Haltaufderhyde2015>{{cite journal | vauthors = Haltaufderhyde K, Ozdeslik RN, Wicks NL, Najera JA, Oancea E | title = Opsin expression in human epidermal skin | journal = Photochemistry and Photobiology | volume = 91 | issue = 1 | pages = 117–23 | date = January 2015 | pmid = 25267311 | doi = 10.1111/php.12354 | pmc=4303996}}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Opsin 3 (encephalopsin, panopsin)
| HGNCid = 14007
| Symbol = OPN3
| AltSymbols =; ECPN
| OMIM = 606695
| ECnumber = 
| Homologene = 40707
| MGIid = 1338022
| GeneAtlas_image1 = PBB_GE_OPN3_219032_x_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0008020 |text = G-protein coupled photoreceptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0007602 |text = phototransduction}} {{GNF_GO|id=GO:0018298 |text = protein-chromophore linkage}} {{GNF_GO|id=GO:0042752 |text = regulation of circadian rhythm}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23596
    | Hs_Ensembl = ENSG00000054277
    | Hs_RefseqProtein = NP_001025182
    | Hs_RefseqmRNA = NM_001030011
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 239823075
    | Hs_GenLoc_end = 239870324
    | Hs_Uniprot = Q9H1Y3
    | Mm_EntrezGene = 13603
    | Mm_Ensembl = ENSMUSG00000026525
    | Mm_RefseqmRNA = NM_010098
    | Mm_RefseqProtein = NP_034228
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 177499096
    | Mm_GenLoc_end = 177529265
    | Mm_Uniprot = Q3KR48
  }}
}}
'''Opsin 3 (encephalopsin, panopsin)''', also known as '''OPN3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OPN3 opsin 3 (encephalopsin, panopsin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23596| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Opsin]]s are members of the [[G protein-coupled receptor]] superfamily. In addition to the visual opsins, mammals possess several [[photoreceptor protein|photoreceptive]] non-visual opsins that are expressed in tissues outside the eye. The opsin-3 gene is strongly expressed in brain and [[testis]] and weakly expressed in liver, [[placenta]], heart, lung, skeletal muscle, [[kidney]], and [[pancreas]]. The gene is expressed in the skin<ref name=Haltaufderhyde2015 /> and may also be expressed in the [[retina]]. The protein has the canonical features of a photoreceptive opsin protein.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. In addition to the visual opsins, mammals possess several photoreceptive non-visual opsins that are expressed in extraocular tissues. This gene, opsin 3, is strongly expressed in brain and testis and weakly expressed in liver, placenta, heart, lung, skeletal muscle, kidney, and pancreas. The gene may also be expressed in the retina. The protein has the canonical features of a photoreceptive opsin protein. Alternative splicing results in multiple transcript variants encoding different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: OPN3 opsin 3 (encephalopsin, panopsin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23596| accessdate = }}</ref>
}}


==See also==
== References ==
* [[Opsin]]
{{reflist}}


==References==
== Further reading ==
{{reflist|2}}
 
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
| citations =
* {{cite journal | vauthors = Halford S, Bellingham J, Ocaka L, Fox M, Johnson S, Foster RG, Hunt DM | title = Assignment of panopsin (OPN3) to human chromosome band 1q43 by in situ hybridization and somatic cell hybrids | journal = Cytogenetics and Cell Genetics | volume = 95 | issue = 3–4 | pages = 234–5 | year = 2002 | pmid = 12063405 | doi = 10.1159/000059351 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
* {{cite journal | vauthors = Kasper G, Taudien S, Staub E, Mennerich D, Rieder M, Hinzmann B, Dahl E, Schwidetzky U, Rosenthal A, Rump A | title = Different structural organization of the encephalopsin gene in man and mouse | journal = Gene | volume = 295 | issue = 1 | pages = 27–32 | date = Jul 2002 | pmid = 12242008 | doi = 10.1016/S0378-1119(02)00799-0 }}
*{{cite journal  | author=Blackshaw S, Snyder SH |title=Encephalopsin: a novel mammalian extraretinal opsin discretely localized in the brain. |journal=J. Neurosci. |volume=19 |issue= 10 |pages= 3681-90 |year= 1999 |pmid= 10234000 |doi=  }}
* {{cite journal | vauthors = Alam NA, Gorman P, Jaeger EE, Kelsell D, Leigh IM, Ratnavel R, Murdoch ME, Houlston RS, Aaltonen LA, Roylance RR, Tomlinson IP | title = Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability | journal = Cancer Genetics and Cytogenetics | volume = 147 | issue = 2 | pages = 121–7 | date = Dec 2003 | pmid = 14623461 | doi = 10.1016/S0165-4608(03)00196-1 }}
*{{cite journal  | author=Halford S, Freedman MS, Bellingham J, ''et al.'' |title=Characterization of a novel human opsin gene with wide tissue expression and identification of embedded and flanking genes on chromosome 1q43. |journal=Genomics |volume=72 |issue= 2 |pages= 203-8 |year= 2001 |pmid= 11401433 |doi= 10.1006/geno.2001.6469 }}
*{{cite journal | author=Halford S, Bellingham J, Ocaka L, ''et al.'' |title=Assignment of panopsin (OPN3) to human chromosome band 1q43 by in situ hybridization and somatic cell hybrids. |journal=Cytogenet. Cell Genet. |volume=95 |issue= 3-4 |pages= 234-5 |year= 2002 |pmid= 12063405 |doi= }}
*{{cite journal | author=Kasper G, Taudien S, Staub E, ''et al.'' |title=Different structural organization of the encephalopsin gene in man and mouse. |journal=Gene |volume=295 |issue= 1 |pages= 27-32 |year= 2003 |pmid= 12242008 |doi= }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Alam NA, Gorman P, Jaeger EE, ''et al.'' |title=Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability. |journal=Cancer Genet. Cytogenet. |volume=147 |issue= 2 |pages= 121-7 |year= 2004 |pmid= 14623461 |doi= }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
}}
{{refend}}
{{refend}}


{{NLM content}}
{{NLM content}}
{{membrane-protein-stub}}
 
{{Eye proteins}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]
[[Category:G protein coupled receptors]]




{{WikiDoc Sources}}
{{transmembranereceptor-stub}}

Revision as of 00:58, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Opsin-3 also known as encephalopsin or panopsin[1] is a protein that, in humans, is encoded by the OPN3 gene.[2][3][4] Alternative splicing of this gene results in multiple transcript variants encoding different protein isoforms.[5]

Function

Opsins are members of the G protein-coupled receptor superfamily. In addition to the visual opsins, mammals possess several photoreceptive non-visual opsins that are expressed in tissues outside the eye. The opsin-3 gene is strongly expressed in brain and testis and weakly expressed in liver, placenta, heart, lung, skeletal muscle, kidney, and pancreas. The gene is expressed in the skin[5] and may also be expressed in the retina. The protein has the canonical features of a photoreceptive opsin protein.[4]

References

  1. ↑ Koyanagi M, Takada E, Nagata T, Tsukamoto H, Terakita A (Mar 2013). "Homologs of vertebrate Opn3 potentially serve as a light sensor in nonphotoreceptive tissue". Proceedings of the National Academy of Sciences of the United States of America. 110 (13): 4998–5003. doi:10.1073/pnas.1219416110. PMC 3612648. PMID 23479626.
  2. ↑ Blackshaw S, Snyder SH (May 1999). "Encephalopsin: a novel mammalian extraretinal opsin discretely localized in the brain". The Journal of Neuroscience. 19 (10): 3681–90. PMID 10234000.
  3. ↑ Halford S, Freedman MS, Bellingham J, Inglis SL, Poopalasundaram S, Soni BG, Foster RG, Hunt DM (Mar 2001). "Characterization of a novel human opsin gene with wide tissue expression and identification of embedded and flanking genes on chromosome 1q43". Genomics. 72 (2): 203–8. doi:10.1006/geno.2001.6469. PMID 11401433.
  4. ↑ 4.0 4.1 "Entrez Gene: OPN3 opsin 3 (encephalopsin, panopsin)".
  5. ↑ 5.0 5.1 Haltaufderhyde K, Ozdeslik RN, Wicks NL, Najera JA, Oancea E (January 2015). "Opsin expression in human epidermal skin". Photochemistry and Photobiology. 91 (1): 117–23. doi:10.1111/php.12354. PMC 4303996. PMID 25267311.

Further reading

  • Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Halford S, Bellingham J, Ocaka L, Fox M, Johnson S, Foster RG, Hunt DM (2002). "Assignment of panopsin (OPN3) to human chromosome band 1q43 by in situ hybridization and somatic cell hybrids". Cytogenetics and Cell Genetics. 95 (3–4): 234–5. doi:10.1159/000059351. PMID 12063405.
  • Kasper G, Taudien S, Staub E, Mennerich D, Rieder M, Hinzmann B, Dahl E, Schwidetzky U, Rosenthal A, Rump A (Jul 2002). "Different structural organization of the encephalopsin gene in man and mouse". Gene. 295 (1): 27–32. doi:10.1016/S0378-1119(02)00799-0. PMID 12242008.
  • Alam NA, Gorman P, Jaeger EE, Kelsell D, Leigh IM, Ratnavel R, Murdoch ME, Houlston RS, Aaltonen LA, Roylance RR, Tomlinson IP (Dec 2003). "Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability". Cancer Genetics and Cytogenetics. 147 (2): 121–7. doi:10.1016/S0165-4608(03)00196-1. PMID 14623461.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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