GNRHR2: Difference between revisions

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{{Infobox_gene}}
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'''Putative gonadotropin-releasing hormone II receptor''' is a [[protein]] that in humans is encoded by the ''GNRHR2'' [[gene]].<ref name="pmid11707068">{{cite journal |vauthors=Faurholm B, Millar RP, Katz AA | title = The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci | journal = Genomics | volume = 78 | issue = 1–2 | pages = 15–8 |date=Nov 2001 | pmid = 11707068 | pmc = | doi = 10.1006/geno.2001.6650 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GNRHR2 gonadotropin-releasing hormone (type 2) receptor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114814| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Gonadotropin-releasing hormone (type 2) receptor 2
| HGNCid = 16341
| Symbol = GNRHR2
| AltSymbols =; GnRH-II-R
| OMIM = 
| ECnumber = 
| Homologene = 
| MGIid = 
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004968 |text = gonadotropin-releasing hormone receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 114814
    | Hs_Ensembl = 
    | Hs_RefseqProtein = 
    | Hs_RefseqmRNA = 
    | Hs_GenLoc_db = 
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    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
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'''Gonadotropin-releasing hormone (type 2) receptor 2''', also known as '''GNRHR2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GNRHR2 gonadotropin-releasing hormone (type 2) receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114814| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The receptor for gonadotropin releasing hormone 2 ([[GnRH2]]) is encoded by the GnRH2 receptor (GnRHR2) gene. In non-hominoid primates and non-mammalian vertebrates, GnRHR2 encodes a seven-transmembrane [[G protein-coupled receptor]]. However, in human, the [[N-terminus]] of the predicted protein contains a frameshift and premature stop codon. In human, GnRHR2 transcription occurs but whether the gene produces a functional [[C-terminus|C-terminal]] multi-transmembrane protein is currently unresolved. Alternative splice variants have been reported. An untranscribed [[pseudogene]] of GnRHR2 is also on chromosome 14.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The receptor for gonadotropin releasing hormone 2 (GnRH2) is encoded by the GnRH2 receptor (GnRHR2) gene. In non-hominoid primates and non-mammalian vertebrates, GnRHR2 encodes a seven-transmembrane G-protein coupled receptor. However, in human, the N-terminus of the predicted protein contains a frameshift and premature stop codon. In human, GnRHR2 transcription occurs but whether the gene produces a functional C-terminal multi-transmembrane protein is currently unresolved. Alternative splice variants have been reported. An untranscribed pseudogene of GnRHR2 is also on chromosome 14.<ref name="entrez">{{cite web | title = Entrez Gene: GNRHR2 gonadotropin-releasing hormone (type 2) receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114814| accessdate = }}</ref>
}}


==See also==
==See also==
Line 57: Line 10:


==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | author=Neill JD |title=GnRH and GnRH receptor genes in the human genome |journal=Endocrinology |volume=143 |issue= 3 |pages= 737–43 |year= 2002 |pmid= 11861490 |doi=10.1210/en.143.3.737 }}
| citations =
*{{cite journal  |vauthors=Millar R, Conklin D, Lofton-Day C |title=A novel human GnRH receptor homolog gene: abundant and wide tissue distribution of the antisense transcript |journal=J. Endocrinol. |volume=162 |issue= 1 |pages= 117–26 |year= 1999 |pmid= 10396028 |doi=10.1677/joe.0.1620117 |display-authors=etal}}
*{{cite journal  | author=Neill JD |title=GnRH and GnRH receptor genes in the human genome. |journal=Endocrinology |volume=143 |issue= 3 |pages= 737-43 |year= 2002 |pmid= 11861490 |doi=  }}
*{{cite journal  |vauthors=Neill JD, Duck LW, Sellers JC, Musgrove LC |title=A gonadotropin-releasing hormone (GnRH) receptor specific for GnRH II in primates |journal=Biochem. Biophys. Res. Commun. |volume=282 |issue= 4 |pages= 1012–8 |year= 2001 |pmid= 11352653 |doi= 10.1006/bbrc.2001.4678 }}
*{{cite journal  | author=Millar R, Conklin D, Lofton-Day C, ''et al.'' |title=A novel human GnRH receptor homolog gene: abundant and wide tissue distribution of the antisense transcript. |journal=J. Endocrinol. |volume=162 |issue= 1 |pages= 117-26 |year= 1999 |pmid= 10396028 |doi=  }}
*{{cite journal  |vauthors=van Biljon W, Wykes S, Scherer S |title=Type II gonadotropin-releasing hormone receptor transcripts in human sperm |journal=Biol. Reprod. |volume=67 |issue= 6 |pages= 1741–9 |year= 2003 |pmid= 12444048 |doi=10.1095/biolreprod.101.002808 |display-authors=etal}}
*{{cite journal  | author=Neill JD, Duck LW, Sellers JC, Musgrove LC |title=A gonadotropin-releasing hormone (GnRH) receptor specific for GnRH II in primates. |journal=Biochem. Biophys. Res. Commun. |volume=282 |issue= 4 |pages= 1012-8 |year= 2001 |pmid= 11352653 |doi= 10.1006/bbrc.2001.4678 }}
*{{cite journal  |vauthors=Morgan K, Conklin D, Pawson AJ |title=A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12 |journal=Endocrinology |volume=144 |issue= 2 |pages= 423–36 |year= 2003 |pmid= 12538601 |doi=10.1210/en.2002-220622 |display-authors=etal}}
*{{cite journal  | author=Faurholm B, Millar RP, Katz AA |title=The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci. |journal=Genomics |volume=78 |issue= 1-2 |pages= 15-8 |year= 2002 |pmid= 11707068 |doi= 10.1006/geno.2001.6650 }}
*{{cite journal  |vauthors=Pawson AJ, Maudsley S, Morgan K |title=Inhibition of human type i gonadotropin-releasing hormone receptor (GnRHR) function by expression of a human type II GnRHR gene fragment |journal=Endocrinology |volume=146 |issue= 6 |pages= 2639–49 |year= 2005 |pmid= 15761034 |doi= 10.1210/en.2005-0133 |display-authors=etal}}
*{{cite journal  | author=van Biljon W, Wykes S, Scherer S, ''et al.'' |title=Type II gonadotropin-releasing hormone receptor transcripts in human sperm. |journal=Biol. Reprod. |volume=67 |issue= 6 |pages= 1741-9 |year= 2003 |pmid= 12444048 |doi=  }}
*{{cite journal  |vauthors=Eicke N, Günthert AR, Viereck V |title=GnRH-II receptor-like antigenicity in human placenta and in cancers of the human reproductive organs |journal=Eur. J. Endocrinol. |volume=153 |issue= 4 |pages= 605–12 |year= 2005 |pmid= 16189182 |doi= 10.1530/eje.1.02005 |display-authors=etal}}
*{{cite journal  | author=Morgan K, Conklin D, Pawson AJ, ''et al.'' |title=A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12. |journal=Endocrinology |volume=144 |issue= 2 |pages= 423-36 |year= 2003 |pmid= 12538601 |doi=  }}
*{{cite journal  |vauthors=Ikemoto T, Park MK |title=Comparative genomics of the endocrine systems in humans and chimpanzees with special reference to GNRH2 and UCN2 and their receptors |journal=Genomics |volume=87 |issue= 4 |pages= 459–62 |year= 2006 |pmid= 16406723 |doi= 10.1016/j.ygeno.2005.11.005 }}
*{{cite journal  | author=Pawson AJ, Maudsley S, Morgan K, ''et al.'' |title=Inhibition of human type i gonadotropin-releasing hormone receptor (GnRHR) function by expression of a human type II GnRHR gene fragment. |journal=Endocrinology |volume=146 |issue= 6 |pages= 2639-49 |year= 2005 |pmid= 15761034 |doi= 10.1210/en.2005-0133 }}
*{{cite journal  |vauthors=Parker JD, Malik M, Catherino WH |title=Human myometrium and leiomyomas express gonadotropin-releasing hormone 2 and gonadotropin-releasing hormone 2 receptor |journal=Fertil. Steril. |volume=88 |issue= 1 |pages= 39–46 |year= 2007 |pmid= 17296196 |doi= 10.1016/j.fertnstert.2006.11.098 }}
*{{cite journal  | author=Eicke N, Günthert AR, Viereck V, ''et al.'' |title=GnRH-II receptor-like antigenicity in human placenta and in cancers of the human reproductive organs. |journal=Eur. J. Endocrinol. |volume=153 |issue= 4 |pages= 605-12 |year= 2005 |pmid= 16189182 |doi= 10.1530/eje.1.02005 }}
*{{cite journal  | author=Ikemoto T, Park MK |title=Comparative genomics of the endocrine systems in humans and chimpanzees with special reference to GNRH2 and UCN2 and their receptors. |journal=Genomics |volume=87 |issue= 4 |pages= 459-62 |year= 2006 |pmid= 16406723 |doi= 10.1016/j.ygeno.2005.11.005 }}
*{{cite journal  | author=Parker JD, Malik M, Catherino WH |title=Human myometrium and leiomyomas express gonadotropin-releasing hormone 2 and gonadotropin-releasing hormone 2 receptor. |journal=Fertil. Steril. |volume=88 |issue= 1 |pages= 39-46 |year= 2007 |pmid= 17296196 |doi= 10.1016/j.fertnstert.2006.11.098 }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
==External links==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3212 | title = Gonadotrophin-Releasing Hormone Receptors: GnRH2 Receptor | accessdate = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
 
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Revision as of 01:01, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Putative gonadotropin-releasing hormone II receptor is a protein that in humans is encoded by the GNRHR2 gene.[1][2]

Function

The receptor for gonadotropin releasing hormone 2 (GnRH2) is encoded by the GnRH2 receptor (GnRHR2) gene. In non-hominoid primates and non-mammalian vertebrates, GnRHR2 encodes a seven-transmembrane G protein-coupled receptor. However, in human, the N-terminus of the predicted protein contains a frameshift and premature stop codon. In human, GnRHR2 transcription occurs but whether the gene produces a functional C-terminal multi-transmembrane protein is currently unresolved. Alternative splice variants have been reported. An untranscribed pseudogene of GnRHR2 is also on chromosome 14.[2]

See also

References

  1. ↑ Faurholm B, Millar RP, Katz AA (Nov 2001). "The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci". Genomics. 78 (1–2): 15–8. doi:10.1006/geno.2001.6650. PMID 11707068.
  2. ↑ 2.0 2.1 "Entrez Gene: GNRHR2 gonadotropin-releasing hormone (type 2) receptor 2".

Further reading

  • Neill JD (2002). "GnRH and GnRH receptor genes in the human genome". Endocrinology. 143 (3): 737–43. doi:10.1210/en.143.3.737. PMID 11861490.
  • Millar R, Conklin D, Lofton-Day C, et al. (1999). "A novel human GnRH receptor homolog gene: abundant and wide tissue distribution of the antisense transcript". J. Endocrinol. 162 (1): 117–26. doi:10.1677/joe.0.1620117. PMID 10396028.
  • Neill JD, Duck LW, Sellers JC, Musgrove LC (2001). "A gonadotropin-releasing hormone (GnRH) receptor specific for GnRH II in primates". Biochem. Biophys. Res. Commun. 282 (4): 1012–8. doi:10.1006/bbrc.2001.4678. PMID 11352653.
  • van Biljon W, Wykes S, Scherer S, et al. (2003). "Type II gonadotropin-releasing hormone receptor transcripts in human sperm". Biol. Reprod. 67 (6): 1741–9. doi:10.1095/biolreprod.101.002808. PMID 12444048.
  • Morgan K, Conklin D, Pawson AJ, et al. (2003). "A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12". Endocrinology. 144 (2): 423–36. doi:10.1210/en.2002-220622. PMID 12538601.
  • Pawson AJ, Maudsley S, Morgan K, et al. (2005). "Inhibition of human type i gonadotropin-releasing hormone receptor (GnRHR) function by expression of a human type II GnRHR gene fragment". Endocrinology. 146 (6): 2639–49. doi:10.1210/en.2005-0133. PMID 15761034.
  • Eicke N, Günthert AR, Viereck V, et al. (2005). "GnRH-II receptor-like antigenicity in human placenta and in cancers of the human reproductive organs". Eur. J. Endocrinol. 153 (4): 605–12. doi:10.1530/eje.1.02005. PMID 16189182.
  • Ikemoto T, Park MK (2006). "Comparative genomics of the endocrine systems in humans and chimpanzees with special reference to GNRH2 and UCN2 and their receptors". Genomics. 87 (4): 459–62. doi:10.1016/j.ygeno.2005.11.005. PMID 16406723.
  • Parker JD, Malik M, Catherino WH (2007). "Human myometrium and leiomyomas express gonadotropin-releasing hormone 2 and gonadotropin-releasing hormone 2 receptor". Fertil. Steril. 88 (1): 39–46. doi:10.1016/j.fertnstert.2006.11.098. PMID 17296196.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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