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{{Infobox_gene}}
 
'''Frizzled-7''' is a [[protein]] that in humans is encoded by the ''FZD7'' [[gene]].<ref name="pmid9707618">{{cite journal |vauthors=Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K | title = A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 17 | pages = 10164–9 | date=September 1998| pmid = 9707618 | pmc = 21479 | doi =10.1073/pnas.95.17.10164 }}</ref><ref name="pmid9813155">{{cite journal |vauthors=Sagara N, Toda G, Hirai M, Terada M, Katoh M | title = Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7 | journal = Biochem Biophys Res Commun | volume = 252 | issue = 1 | pages = 117–22 | date=December 1998| pmid = 9813155 | pmc =  | doi = 10.1006/bbrc.1998.9607 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FZD7 frizzled homolog 7 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8324| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Frizzled homolog 7 (Drosophila)
| HGNCid = 4045
| Symbol = FZD7
| AltSymbols =; FzE3
| OMIM = 603410
| ECnumber =
| Homologene = 20751
| MGIid = 108570
| GeneAtlas_image1 = PBB_GE_FZD7_203706_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_FZD7_203705_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004926 |text = non-G-protein coupled 7TM receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0042813 |text = Wnt receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007222 |text = Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8324
    | Hs_Ensembl = ENSG00000155760
    | Hs_RefseqProtein = NP_003498
    | Hs_RefseqmRNA = NM_003507
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 202607555
    | Hs_GenLoc_end = 202611405
    | Hs_Uniprot = O75084
    | Mm_EntrezGene = 14369
    | Mm_Ensembl = ENSMUSG00000041075
    | Mm_RefseqmRNA = NM_008057
    | Mm_RefseqProtein = NP_032083
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 59426725
    | Mm_GenLoc_end = 59431505
    | Mm_Uniprot = Q6P551
  }}
}}
'''Frizzled homolog 7 (Drosophila)''', also known as '''FZD7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FZD7 frizzled homolog 7 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8324| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =
| summary_text = Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins.  The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif.  FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.<ref name="entrez">{{cite web | title = Entrez Gene: FZD7 frizzled homolog 7 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8324| accessdate = }}</ref>
| summary_text = Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins.  The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif.  FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.<ref name="entrez"/>
}}
}}
==Interactions==
FZD7 has been shown to [[Protein-protein interaction|interact]] with [[DLG4]].<ref name=pmid12067714>{{cite journal |last=Hering |first=Heike |authorlink= |author2=Sheng Morgan |date=June 2002|title=Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95 |journal=FEBS Lett. |volume=521 |issue=1–3 |pages=185–9 |publisher= |location = Netherlands| issn = 0014-5793| pmid = 12067714 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0014-5793(02)02831-4 }}</ref>


==See also==
==See also==
Line 61: Line 15:


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3065 | title = Frizzled Receptors: FZD<sub>7</sub> | accessdate = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading
| citations =  
| citations =
*{{cite journal  | author=Finch PW, He X, Kelley MJ, ''et al.'' |title=Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 13 |pages= 6770-5 |year= 1997 |pmid= 9192640 |doi= }}
*{{cite journal  |vauthors=Finch PW, He X, Kelley MJ |title=Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 13 |pages= 6770–5 |year= 1997 |pmid= 9192640 |doi=10.1073/pnas.94.13.6770  | pmc=21233 |display-authors=etal}}
*{{cite journal  | author=Tanaka S, Akiyoshi T, Mori M, ''et al.'' |title=A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 17 |pages= 10164-9 |year= 1998 |pmid= 9707618 |doi=  }}
*{{cite journal  |vauthors=Hering H, Sheng M |title=Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95 |journal=FEBS Lett. |volume=521 |issue= 1–3 |pages= 185–9 |year= 2002 |pmid= 12067714 |doi=10.1016/S0014-5793(02)02831-4 }}
*{{cite journal  | author=Sagara N, Toda G, Hirai M, ''et al.'' |title=Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7. |journal=Biochem. Biophys. Res. Commun. |volume=252 |issue= 1 |pages= 117-22 |year= 1998 |pmid= 9813155 |doi= 10.1006/bbrc.1998.9607 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Hering H, Sheng M |title=Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95. |journal=FEBS Lett. |volume=521 |issue= 1-3 |pages= 185-9 |year= 2002 |pmid= 12067714 |doi=  }}
*{{cite journal  |vauthors=Yao R, Natsume Y, Noda T |title=MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap |journal=Oncogene |volume=23 |issue= 36 |pages= 6023–30 |year= 2005 |pmid= 15195140 |doi= 10.1038/sj.onc.1207817 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Omoto S, Hayashi T, Kitahara K |title=Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R) |journal=Ophthalmic Genet. |volume=25 |issue= 2 |pages= 81–90 |year= 2004 |pmid= 15370539 |doi= 10.1080/13816810490514270 |display-authors=etal}}
*{{cite journal  | author=Yao R, Natsume Y, Noda T |title=MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap. |journal=Oncogene |volume=23 |issue= 36 |pages= 6023-30 |year= 2005 |pmid= 15195140 |doi= 10.1038/sj.onc.1207817 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Omoto S, Hayashi T, Kitahara K, ''et al.'' |title=Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R). |journal=Ophthalmic Genet. |volume=25 |issue= 2 |pages= 81-90 |year= 2004 |pmid= 15370539 |doi= 10.1080/13816810490514270 }}
*{{cite journal  |vauthors=Vincan E, Darcy PK, Smyth MJ |title=Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth |journal=Differentiation |volume=73 |issue= 4 |pages= 142–53 |year= 2005 |pmid= 15901282 |doi= 10.1111/j.1432-0436.2005.00015.x |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Vincan E, Darcy PK, Smyth MJ, ''et al.'' |title=Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth. |journal=Differentiation |volume=73 |issue= 4 |pages= 142-53 |year= 2005 |pmid= 15901282 |doi= 10.1111/j.1432-0436.2005.00015.x }}
*{{cite journal  |vauthors=Lim J, Hao T, Shaw C |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |display-authors=etal}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  |vauthors=Vincan E, Darcy PK, Farrelly CA |title=Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids |journal=Oncogene |volume=26 |issue= 16 |pages= 2340–52 |year= 2007 |pmid= 17016432 |doi= 10.1038/sj.onc.1210026 |display-authors=etal}}
*{{cite journal  | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal  |vauthors=Struewing IT, Barnett CD, Zhang W |title=Frizzled-7 turnover at the plasma membrane is regulated by cell density and the Ca(2+) -dependent protease calpain-1 |journal=Exp. Cell Res. |volume=313 |issue= 16 |pages= 3526–41 |year= 2007 |pmid= 17716656 |doi= 10.1016/j.yexcr.2007.07.012 |display-authors=etal}}
*{{cite journal  | author=Vincan E, Darcy PK, Farrelly CA, ''et al.'' |title=Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids. |journal=Oncogene |volume=26 |issue= 16 |pages= 2340-52 |year= 2007 |pmid= 17016432 |doi= 10.1038/sj.onc.1210026 }}
*{{cite journal  | author=Struewing IT, Barnett CD, Zhang W, ''et al.'' |title=Frizzled-7 turnover at the plasma membrane is regulated by cell density and the Ca(2+) -dependent protease calpain-1. |journal=Exp. Cell Res. |volume=313 |issue= 16 |pages= 3526-41 |year= 2007 |pmid= 17716656 |doi= 10.1016/j.yexcr.2007.07.012 }}
}}
}}
{{refend}}
{{refend}}


{{NLM content}}
{{NLM content}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors|g4}}
 
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{{DEFAULTSORT:Fzd7}}
[[Category:G protein coupled receptors]]
[[Category:G protein coupled receptors]]


{{WH}}
 
{{WS}}
{{transmembranereceptor-stub}}

Revision as of 05:00, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Frizzled-7 is a protein that in humans is encoded by the FZD7 gene.[1][2][3]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.[3]

Interactions

FZD7 has been shown to interact with DLG4.[4]

See also

References

  1. ↑ Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (September 1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proc Natl Acad Sci U S A. 95 (17): 10164–9. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618.
  2. ↑ Sagara N, Toda G, Hirai M, Terada M, Katoh M (December 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochem Biophys Res Commun. 252 (1): 117–22. doi:10.1006/bbrc.1998.9607. PMID 9813155.
  3. ↑ 3.0 3.1 "Entrez Gene: FZD7 frizzled homolog 7 (Drosophila)".
  4. ↑ Hering, Heike; Sheng Morgan (June 2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Lett. Netherlands. 521 (1–3): 185–9. doi:10.1016/S0014-5793(02)02831-4. ISSN 0014-5793. PMID 12067714.

External links

  • "Frizzled Receptors: FZD7". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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