GPR45: Difference between revisions

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{{Infobox_gene}}
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'''Probable G-protein coupled receptor 45''' is a [[protein]] that in humans is encoded by the ''GPR45'' [[gene]].<ref name="pmid10036181">{{cite journal |vauthors=Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF | title = Discovery of three novel orphan G-protein-coupled receptors | journal = Genomics | volume = 56 | issue = 1 | pages = 12–21 |date=May 1999 | pmid = 10036181 | pmc =  | doi = 10.1006/geno.1998.5655 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GPR45 G protein-coupled receptor 45| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11250| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = G protein-coupled receptor 45
| HGNCid = 4503
| Symbol = GPR45
| AltSymbols =; PSP24; PSP24(ALPHA); PSP24A
| OMIM = 604838
| ECnumber = 
| Homologene = 5228
| MGIid = 2135882
| GeneAtlas_image1 = PBB_GE_GPR45_211175_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007399 |text = nervous system development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11250
    | Hs_Ensembl = ENSG00000135973
    | Hs_RefseqProtein = NP_009158
    | Hs_RefseqmRNA = NM_007227
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 105224632
    | Hs_GenLoc_end = 105226356
    | Hs_Uniprot = Q9Y5Y3
    | Mm_EntrezGene = 93690
    | Mm_Ensembl = ENSMUSG00000041907
    | Mm_RefseqmRNA = NM_053107
    | Mm_RefseqProtein = NP_444337
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 42897418
    | Mm_GenLoc_end = 42979995
    | Mm_Uniprot = Q148B5
  }}
}}
'''G protein-coupled receptor 45''', also known as '''GPR45''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPR45 G protein-coupled receptor 45| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11250| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system.<ref name="entrez">{{cite web | title = Entrez Gene: GPR45 G protein-coupled receptor 45| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11250| accessdate = }}</ref>
| summary_text = This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Marchese A, Sawzdargo M, Nguyen T, ''et al.'' |title=Discovery of three novel orphan G-protein-coupled receptors. |journal=Genomics |volume=56 |issue= 1 |pages= 12-21 |year= 1999 |pmid= 10036181 |doi= 10.1006/geno.1998.5655 }}
*{{cite journal   |vauthors=Kawasawa Y, Kume K, Nakade S, etal |title=Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45 |journal=Biochem. Biophys. Res. Commun. |volume=276 |issue= 3 |pages= 952–6 |year= 2000 |pmid= 11027574 |doi= 10.1006/bbrc.2000.3569 }}
*{{cite journal  | author=Kawasawa Y, Kume K, Nakade S, ''et al.'' |title=Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45. |journal=Biochem. Biophys. Res. Commun. |volume=276 |issue= 3 |pages= 952-6 |year= 2000 |pmid= 11027574 |doi= 10.1006/bbrc.2000.3569 }}
*{{cite journal  |vauthors=Kawasawa Y, Kume K, Izumi T, Shimizu T |title=Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems |journal=Biochem. Biophys. Res. Commun. |volume=276 |issue= 3 |pages= 957–64 |year= 2000 |pmid= 11027575 |doi= 10.1006/bbrc.2000.3570 }}
*{{cite journal  | author=Kawasawa Y, Kume K, Izumi T, Shimizu T |title=Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems. |journal=Biochem. Biophys. Res. Commun. |volume=276 |issue= 3 |pages= 957-64 |year= 2000 |pmid= 11027575 |doi= 10.1006/bbrc.2000.3570 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Hillier LW, Graves TA, Fulton RS, etal |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4 |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
}}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
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[[Category:G protein coupled receptors]]
[[Category:G protein coupled receptors]]
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{{transmembranereceptor-stub}}

Revision as of 09:00, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

Probable G-protein coupled receptor 45 is a protein that in humans is encoded by the GPR45 gene.[1][2]

This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system.[2]

References

  1. ↑ Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF (May 1999). "Discovery of three novel orphan G-protein-coupled receptors". Genomics. 56 (1): 12–21. doi:10.1006/geno.1998.5655. PMID 10036181.
  2. ↑ 2.0 2.1 "Entrez Gene: GPR45 G protein-coupled receptor 45".

Further reading


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