P2RY13: Difference between revisions

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{{Infobox_gene}}
 
'''P2Y purinoceptor 13''' is a [[protein]] that in humans is encoded by the ''P2RY13'' [[gene]].<ref name="pmid11273702">{{cite journal | vauthors = Wittenberger T, Schaller HC, Hellebrand S | title = An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors | journal = J Mol Biol | volume = 307 | issue = 3 | pages = 799–813 |date=Mar 2001 | pmid = 11273702 | pmc =  | doi = 10.1006/jmbi.2001.4520 }}</ref><ref name="pmid11574155">{{cite journal | vauthors = Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF | title = Discovery and mapping of ten novel G protein-coupled receptor genes | journal = Gene | volume = 275 | issue = 1 | pages = 83–91 |date=Sep 2001 | pmid = 11574155 | pmc = | doi =10.1016/S0378-1119(01)00651-5 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: P2RY13 purinergic receptor P2Y, G-protein coupled, 13| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53829| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =  
| Name = Purinergic receptor P2Y, G-protein coupled, 13
| HGNCid = 4537
| Symbol = P2RY13
| AltSymbols =; GPCR1; FKSG77; GPR86; GPR94; P2Y13; SP174
| OMIM = 606380
| ECnumber =
| Homologene = 12543
| MGIid = 1921441
  | GeneAtlas_image1 = PBB_GE_P2RY13_220005_at_tn.png
| Function =
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 53829
    | Hs_Ensembl = ENSG00000181631
    | Hs_RefseqProtein = NP_076403
    | Hs_RefseqmRNA = NM_023914
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 152526786
    | Hs_GenLoc_end = 152530025
    | Hs_Uniprot = Q9BPV8
    | Mm_EntrezGene = 74191
    | Mm_Ensembl = ENSMUSG00000036362
    | Mm_RefseqmRNA = NM_028808
    | Mm_RefseqProtein = NP_083084
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 59295825
    | Mm_GenLoc_end = 59298811
    | Mm_Uniprot = Q0VF10
  }}
}}
'''Purinergic receptor P2Y, G-protein coupled, 13''', also known as '''P2RY13''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: P2RY13 purinergic receptor P2Y, G-protein coupled, 13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53829| accessdate = }}</ref>


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{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is activated by ADP. Two transcript variants encoding the same protein have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: P2RY13 purinergic receptor P2Y, G-protein coupled, 13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53829| accessdate = }}</ref>
| summary_text = The product of this gene, P2Y<sub>13</sub>, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is activated by ADP. Two transcript variants encoding the same protein have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: P2RY13 purinergic receptor P2Y, G-protein coupled, 13| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53829| accessdate = }}</ref>
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3034 | title = P2Y Receptors: P2Y<sub>13</sub> | accessdate = | date = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = }}


==Further reading==
==Further reading==
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| citations =  
| citations =  
*{{cite journal | author=Wittenberger T, Schaller HC, Hellebrand S |title=An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors. |journal=J. Mol. Biol. |volume=307 |issue= 3 |pages= 799-813 |year= 2001 |pmid= 11273702 |doi= 10.1006/jmbi.2001.4520 }}
*{{cite journal   |vauthors=Communi D, Gonzalez NS, Detheux M, etal |title=Identification of a novel human ADP receptor coupled to G(i). |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 41479–85 |year= 2001 |pmid= 11546776 |doi= 10.1074/jbc.M105912200 }}
*{{cite journal  | author=Communi D, Gonzalez NS, Detheux M, ''et al.'' |title=Identification of a novel human ADP receptor coupled to G(i). |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 41479-85 |year= 2001 |pmid= 11546776 |doi= 10.1074/jbc.M105912200 }}
*{{cite journal   |vauthors=Zhang FL, Luo L, Gustafson E, etal |title=P2Y(13): identification and characterization of a novel Galphai-coupled ADP receptor from human and mouse. |journal=J. Pharmacol. Exp. Ther. |volume=301 |issue= 2 |pages= 705–13 |year= 2002 |pmid= 11961076 |doi=10.1124/jpet.301.2.705 }}
*{{cite journal | author=Lee DK, Nguyen T, Lynch KR, ''et al.'' |title=Discovery and mapping of ten novel G protein-coupled receptor genes. |journal=Gene |volume=275 |issue= 1 |pages= 83-91 |year= 2001 |pmid= 11574155 |doi=  }}
*{{cite journal   |vauthors=Takeda S, Kadowaki S, Haga T, etal |title=Identification of G protein-coupled receptor genes from the human genome sequence. |journal=FEBS Lett. |volume=520 |issue= 1–3 |pages= 97–101 |year= 2002 |pmid= 12044878 |doi=10.1016/S0014-5793(02)02775-8 }}
*{{cite journal  | author=Zhang FL, Luo L, Gustafson E, ''et al.'' |title=P2Y(13): identification and characterization of a novel Galphai-coupled ADP receptor from human and mouse. |journal=J. Pharmacol. Exp. Ther. |volume=301 |issue= 2 |pages= 705-13 |year= 2002 |pmid= 11961076 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Takeda S, Kadowaki S, Haga T, ''et al.'' |title=Identification of G protein-coupled receptor genes from the human genome sequence. |journal=FEBS Lett. |volume=520 |issue= 1-3 |pages= 97-101 |year= 2002 |pmid= 12044878 |doi=  }}
*{{cite journal  |vauthors=Fabre AC, Malaval C, Ben Addi A, etal |title=P2Y13 receptor is critical for reverse cholesterol transport |journal=Hepatology |volume=52 |issue= 4 |pages= 1477–83 |year= 2010 |pmid= 20830789 |doi= 10.1002/hep.23897 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
}}
{{refend}}
{{refend}}
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{{NLM content}}
{{NLM content}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
{{Purinergics}}
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[[Category:G protein coupled receptors]]
[[Category:G protein coupled receptors]]


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Revision as of 17:26, 7 September 2017

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SpeciesHumanMouse
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Wikidata
View/Edit Human

P2Y purinoceptor 13 is a protein that in humans is encoded by the P2RY13 gene.[1][2][3]

The product of this gene, P2Y13, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is activated by ADP. Two transcript variants encoding the same protein have been identified for this gene.[3]

See also

References

  1. ↑ Wittenberger T, Schaller HC, Hellebrand S (Mar 2001). "An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors". J Mol Biol. 307 (3): 799–813. doi:10.1006/jmbi.2001.4520. PMID 11273702.
  2. ↑ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene. 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155.
  3. ↑ 3.0 3.1 "Entrez Gene: P2RY13 purinergic receptor P2Y, G-protein coupled, 13".

External links

  • "P2Y Receptors: P2Y13". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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