FZD8: Difference between revisions

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{{Infobox_gene}}
'''Frizzled-8''' is a [[protein]] that in humans is encoded by the ''FZD8'' [[gene]].<ref name="pmid11295046">{{cite journal |vauthors=Saitoh T, Hirai M, Katoh M | title = Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2 | journal = Int J Oncol | volume = 18 | issue = 5 | pages = 991–6 | date = Apr 2001 | pmid = 11295046 | pmc =  | doi = 10.3892/ijo.18.5.991 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FZD8 frizzled homolog 8 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8325| accessdate = }}</ref>


== Function ==


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This intronless gene is a member of the [[frizzled]] gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.<ref name="entrez" />
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FZD8_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ijy.
| PDB = {{PDB2|1ijy}}
| Name = Frizzled homolog 8 (Drosophila)
| HGNCid = 4046
| Symbol = FZD8
| AltSymbols =; FZ-8; hFZ8
| OMIM = 606146
| ECnumber = 
| Homologene = 40606
| MGIid = 108460
| GeneAtlas_image1 = PBB_GE_FZD8_216587_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004926 |text = non-G-protein coupled 7TM receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0017147 |text = Wnt-protein binding}} {{GNF_GO|id=GO:0042813 |text = Wnt receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007222 |text = Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8325
    | Hs_Ensembl = ENSG00000177283
    | Hs_RefseqProtein = NP_114072
    | Hs_RefseqmRNA = NM_031866
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 35967183
    | Hs_GenLoc_end = 35970368
    | Hs_Uniprot = Q9H461
    | Mm_EntrezGene = 14370
    | Mm_Ensembl = ENSMUSG00000036904
    | Mm_RefseqmRNA = NM_008058
    | Mm_RefseqProtein = NP_032084
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 9212918
    | Mm_GenLoc_end = 9214975
    | Mm_Uniprot = Q61091
  }}
}}
'''Frizzled homolog 8 (Drosophila)''', also known as '''FZD8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FZD8 frizzled homolog 8 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8325| accessdate = }}</ref>
 
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.<ref name="entrez">{{cite web | title = Entrez Gene: FZD8 frizzled homolog 8 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8325| accessdate = }}</ref>
}}


==See also==
==See also==
Line 60: Line 10:


==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal |vauthors=Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J | title = A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled | journal = J. Biol. Chem. | volume = 271 | issue = 8 | pages = 4468–4476 | year = 1996 | pmid = 8626800 | doi = 10.1074/jbc.271.8.4468 }}
| citations =
*{{cite journal |vauthors=Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS | title = Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 13 | pages = 6770–6775 | year = 1997 | pmid = 9192640 | pmc = 21233 | doi = 10.1073/pnas.94.13.6770 }}
*{{cite journal | author=Wang Y, Macke JP, Abella BS, ''et al.'' |title=A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. |journal=J. Biol. Chem. |volume=271 |issue= 8 |pages= 4468-76 |year= 1996 |pmid= 8626800 |doi= }}
*{{cite journal |vauthors=Tamai K, Semenov M, Kato Y, Spokony R, Liu C, Katsuyama Y, Hess F, Saint-Jeannet JP, He X | title = LDL-receptor-related proteins in Wnt signal transduction | journal = Nature | volume = 407 | issue = 6803 | pages = 530–535 | year = 2000 | pmid = 11029007 | doi = 10.1038/35035117 }}
*{{cite journal | author=Finch PW, He X, Kelley MJ, ''et al.'' |title=Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 13 |pages= 6770-5 |year= 1997 |pmid= 9192640 |doi= }}
*{{cite journal |vauthors=Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Res. | volume = 10 | issue = 11 | pages = 1788–1795 | year = 2001 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
*{{cite journal | author=Tamai K, Semenov M, Kato Y, ''et al.'' |title=LDL-receptor-related proteins in Wnt signal transduction. |journal=Nature |volume=407 |issue= 6803 |pages= 530-5 |year= 2000 |pmid= 11029007 |doi= 10.1038/35035117 }}
*{{cite journal |vauthors=Semënov MV, Tamai K, Brott BK, Kühl M, Sokol S, He X | title = Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6 | journal = Curr. Biol. | volume = 11 | issue = 12 | pages = 951–961 | year = 2001 | pmid = 11448771 | doi = 10.1016/S0960-9822(01)00290-1 }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
*{{cite journal |vauthors=Dann CE, Hsieh JC, Rattner A, Sharma D, Nathans J, Leahy DJ | title = Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains | journal = Nature | volume = 412 | issue = 6842 | pages = 86–90 | year = 2001 | pmid = 11452312 | doi = 10.1038/35083601 }}
*{{cite journal  | author=Saitoh T, Hirai M, Katoh M |title=Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2. |journal=Int. J. Oncol. |volume=18 |issue= 5 |pages= 991-6 |year= 2001 |pmid= 11295046 |doi=  }}
*{{cite journal |vauthors=Yao R, Maeda T, Takada S, Noda T | title = Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled | journal = Biochem. Biophys. Res. Commun. | volume = 286 | issue = 4 | pages = 771–778 | year = 2001 | pmid = 11520064 | doi = 10.1006/bbrc.2001.5430 }}
*{{cite journal | author=Semënov MV, Tamai K, Brott BK, ''et al.'' |title=Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. |journal=Curr. Biol. |volume=11 |issue= 12 |pages= 951-61 |year= 2001 |pmid= 11448771 |doi= }}
*{{cite journal |vauthors=Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y | title = Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R) | journal = Ophthalmic Genet. | volume = 25 | issue = 2 | pages = 81–90 | year = 2004 | pmid = 15370539 | doi = 10.1080/13816810490514270 }}
*{{cite journal | author=Dann CE, Hsieh JC, Rattner A, ''et al.'' |title=Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains. |journal=Nature |volume=412 |issue= 6842 |pages= 86-90 |year= 2001 |pmid= 11452312 |doi= 10.1038/35083601 }}
*{{cite journal |vauthors=Lu W, Yamamoto V, Ortega B, Baltimore D | title = Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth | journal = Cell | volume = 119 | issue = 1 | pages = 97–108 | year = 2004 | pmid = 15454084 | doi = 10.1016/j.cell.2004.09.019 }}
*{{cite journal | author=Yao R, Maeda T, Takada S, Noda T |title=Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled. |journal=Biochem. Biophys. Res. Commun. |volume=286 |issue= 4 |pages= 771-8 |year= 2001 |pmid= 11520064 |doi= 10.1006/bbrc.2001.5430 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Deloukas P, Earthrowl ME, Grafham DV, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375-81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 }}
*{{cite journal  | author=Omoto S, Hayashi T, Kitahara K, ''et al.'' |title=Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R). |journal=Ophthalmic Genet. |volume=25 |issue= 2 |pages= 81-90 |year= 2004 |pmid= 15370539 |doi= 10.1080/13816810490514270 }}
*{{cite journal | author=Lu W, Yamamoto V, Ortega B, Baltimore D |title=Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. |journal=Cell |volume=119 |issue= 1 |pages= 97-108 |year= 2004 |pmid= 15454084 |doi= 10.1016/j.cell.2004.09.019 }}
}}
{{refend}}
{{refend}}
==External links==
*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3066 | title = Frizzled Receptors: FZD<sub>8</sub> | accessdate = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
{{PDB Gallery|geneid=8325}}
{{G protein-coupled receptors|g4}}


{{NLM content}}
{{NLM content}}
{{G protein-coupled receptors}}
 
[[Category:G protein coupled receptors]]
[[Category:G protein coupled receptors]]


{{WH}}
 
{{WS}}
{{transmembranereceptor-stub}}

Revision as of 00:58, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Frizzled-8 is a protein that in humans is encoded by the FZD8 gene.[1][2]

Function

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.[2]

See also

References

  1. ↑ Saitoh T, Hirai M, Katoh M (Apr 2001). "Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2". Int J Oncol. 18 (5): 991–6. doi:10.3892/ijo.18.5.991. PMID 11295046.
  2. ↑ 2.0 2.1 "Entrez Gene: FZD8 frizzled homolog 8 (Drosophila)".

Further reading

External links

  • "Frizzled Receptors: FZD8". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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