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{{Infobox_gene}}
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'''G-protein coupled receptor 120''' is a [[protein]] that in humans is encoded by the ''GPR120'' [[gene]].<ref name="pmid14623098">{{cite journal |vauthors=Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB | title = Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives | journal = FEBS Lett | volume = 554 | issue = 3 | pages = 381–8 | date = Nov 2003 | pmid = 14623098 | pmc =  | doi = 10.1016/S0014-5793(03)01196-7 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GPR120 G protein-coupled receptor 120| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=338557| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
GPR120 is a member of the rhodopsin family of [[G protein-coupled receptor]]s (GPRs).<ref name="pmid14623098"/><ref name="entrez" />
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = G protein-coupled receptor 120
| HGNCid = 19061
| Symbol = GPR120
| AltSymbols =; GPR129; GT01; MGC119984; PGR4
| OMIM = 609044
| ECnumber = 
| Homologene = 18769
| MGIid = 2147577
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005504 |text = fatty acid binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0030139 |text = endocytic vesicle}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0046879 |text = hormone secretion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 338557
    | Hs_Ensembl = ENSG00000186188
    | Hs_RefseqProtein = NP_859529
    | Hs_RefseqmRNA = NM_181745
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 95316412
    | Hs_GenLoc_end = 95339819
    | Hs_Uniprot = Q5NUL3
    | Mm_EntrezGene = 107221
    | Mm_Ensembl = ENSMUSG00000054200
    | Mm_RefseqmRNA = NM_181748
    | Mm_RefseqProtein = NP_861413
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 38162223
    | Mm_GenLoc_end = 38179413
    | Mm_Uniprot = Q3V2S5
  }}
}}
'''G protein-coupled receptor 120''', also known as '''GPR120''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPR120 G protein-coupled receptor 120| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=338557| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
GPR120 has also been shown to mediate the [[inflammation|anti-inflammatory]] and [[insulin]]-sensitizing effects of [[omega 3 fatty acids]].<ref>{{cite journal |vauthors=Oh DY, Talukdar S, Bae EJ, Imamura T, Morinaga H, Fan W, Li P, Lu WJ, Watkins SM, Olefsky JM | title = GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects | journal = Cell | volume = 142 | issue = 5 | pages = 687–698 | year = 2010 | pmid = 20813258 | pmc = 2956412 | doi = 10.1016/j.cell.2010.07.041 }}</ref> Lack of GPR120 is responsible for reduced fat metabolism, thereby leading to [[obesity]].<ref name="pmid22343897">{{cite journal |vauthors=Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, Yengo L | title = Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human | journal = Nature | volume = 483 | issue = 7389 | pages = 350–4 | year = 2012 | pmid = 22343897 | doi = 10.1038/nature10798 |display-authors=etal}}</ref>
{{PBB_Summary
 
| section_title =  
Additionally, GPR120 has been implicated to be involved in the ability to [[taste]] fats.<ref>{{pmid|24631296}}</ref> It is expressed in [[taste bud]] cells (specifically cell type II, which contain other G-protein coupled taste receptors), and its absence leads to reduced preference to two types of fatty acid ([[linoleic acid]] and [[oleic acid]]), as well as decreased neuronal response to oral fatty acids.<ref>{{pmid| 20573884}}</ref>
| summary_text = GPR120 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: GPR120 G protein-coupled receptor 120| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=338557| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal |vauthors=Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA | title = The G protein-coupled receptor repertoires of human and mouse | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 8 | pages = 4903–8 | year = 2003 | pmid = 12679517 | pmc = 153653 | doi = 10.1073/pnas.0230374100 }}
| citations =
*{{cite journal |vauthors=Hirasawa A, Tsumaya K, Awaji T, Katsuma S, Adachi T, Yamada M, Sugimoto Y, Miyazaki S, Tsujimoto G | title = Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120 | journal = Nat. Med. | volume = 11 | issue = 1 | pages = 90–4 | year = 2005 | pmid = 15619630 | doi = 10.1038/nm1168 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal |vauthors=Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS | title = Transcriptome analysis of human gastric cancer | journal = Mamm. Genome | volume = 16 | issue = 12 | pages = 942–54 | year = 2006 | pmid = 16341674 | doi = 10.1007/s00335-005-0075-2 }}
*{{cite journal  | author=Vassilatis DK, Hohmann JG, Zeng H, ''et al.'' |title=The G protein-coupled receptor repertoires of human and mouse. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 8 |pages= 4903-8 |year= 2003 |pmid= 12679517 |doi= 10.1073/pnas.0230374100 }}
*{{cite journal | author=Fredriksson R, Höglund PJ, Gloriam DE, ''et al.'' |title=Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. |journal=FEBS Lett. |volume=554 |issue= 3 |pages= 381-8 |year= 2003 |pmid= 14623098 |doi=  }}
*{{cite journal  | author=Deloukas P, Earthrowl ME, Grafham DV, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375-81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 }}
*{{cite journal  | author=Hirasawa A, Tsumaya K, Awaji T, ''et al.'' |title=Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. |journal=Nat. Med. |volume=11 |issue= 1 |pages= 90-4 |year= 2005 |pmid= 15619630 |doi= 10.1038/nm1168 }}
*{{cite journal | author=Oh JH, Yang JO, Hahn Y, ''et al.'' |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942-54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2 }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]
[[Category:G protein coupled receptors]]
{{WikiDoc Sources}}
 
 
{{transmembranereceptor-stub}}

Revision as of 01:13, 27 October 2017

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

G-protein coupled receptor 120 is a protein that in humans is encoded by the GPR120 gene.[1][2]

GPR120 is a member of the rhodopsin family of G protein-coupled receptors (GPRs).[1][2]

GPR120 has also been shown to mediate the anti-inflammatory and insulin-sensitizing effects of omega 3 fatty acids.[3] Lack of GPR120 is responsible for reduced fat metabolism, thereby leading to obesity.[4]

Additionally, GPR120 has been implicated to be involved in the ability to taste fats.[5] It is expressed in taste bud cells (specifically cell type II, which contain other G-protein coupled taste receptors), and its absence leads to reduced preference to two types of fatty acid (linoleic acid and oleic acid), as well as decreased neuronal response to oral fatty acids.[6]

References

  1. ↑ 1.0 1.1 Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (Nov 2003). "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives". FEBS Lett. 554 (3): 381–8. doi:10.1016/S0014-5793(03)01196-7. PMID 14623098.
  2. ↑ 2.0 2.1 "Entrez Gene: GPR120 G protein-coupled receptor 120".
  3. ↑ Oh DY, Talukdar S, Bae EJ, Imamura T, Morinaga H, Fan W, Li P, Lu WJ, Watkins SM, Olefsky JM (2010). "GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects". Cell. 142 (5): 687–698. doi:10.1016/j.cell.2010.07.041. PMC 2956412. PMID 20813258.
  4. ↑ Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, Yengo L, et al. (2012). "Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human". Nature. 483 (7389): 350–4. doi:10.1038/nature10798. PMID 22343897.
  5. ↑ PMID 24631296
  6. ↑ PMID 20573884

Further reading


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