LGR4: Difference between revisions
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{{ | '''Leucine-rich repeat-containing G-protein coupled receptor 4''' is a [[protein]] that in humans is encoded by the ''LGR4'' [[gene]].<ref name="pmid10894923">{{cite journal |vauthors=Loh ED, Broussard SR, Liu Q, Copeland NG, Gilbert DJ, Jenkins NA, ((Kolakowski LF Jr)) | title = Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping | journal = Cytogenet Cell Genet | volume = 89 | issue = 1–2 | pages = 2–5 |date=Aug 2000 | pmid = 10894923 | pmc = | doi =10.1159/000015576 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LGR4 leucine-rich repeat-containing G protein-coupled receptor 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55366| accessdate = }}</ref> LGR4 is known to have a role in the development of the male reproductive tract, eyelids, hair and bone. | ||
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Mutations in this gene have been associated to [[osteoporosis]] (doi:10.1038/nature12124). | |||
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==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
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*{{cite journal | | *{{cite journal |vauthors=Hsu SY, Liang SG, Hsueh AJ |title=Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region |journal=Mol. Endocrinol. |volume=12 |issue= 12 |pages= 1830–45 |year= 1999 |pmid= 9849958 |doi=10.1210/me.12.12.1830 }} | ||
*{{cite journal |vauthors=Loh ED, Broussard SR, Kolakowski LF |title=Molecular characterization of a novel glycoprotein hormone G-protein-coupled receptor |journal=Biochem. Biophys. Res. Commun. |volume=282 |issue= 3 |pages= 757–64 |year= 2001 |pmid= 11401528 |doi= 10.1006/bbrc.2001.4625 }} | |||
*{{cite journal | | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
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{{refend}} | {{refend}} | ||
{{G protein-coupled receptors}} | {{G protein-coupled receptors}} | ||
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[[Category:G protein coupled receptors]] | [[Category:G protein coupled receptors]] | ||
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Revision as of 17:54, 2 September 2017
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Species | Human | Mouse | |||||
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Leucine-rich repeat-containing G-protein coupled receptor 4 is a protein that in humans is encoded by the LGR4 gene.[1][2] LGR4 is known to have a role in the development of the male reproductive tract, eyelids, hair and bone.
Mutations in this gene have been associated to osteoporosis (doi:10.1038/nature12124).
References
- ↑ Loh ED, Broussard SR, Liu Q, Copeland NG, Gilbert DJ, Jenkins NA, Kolakowski LF Jr (Aug 2000). "Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping". Cytogenet Cell Genet. 89 (1–2): 2–5. doi:10.1159/000015576. PMID 10894923.
- ↑ "Entrez Gene: LGR4 leucine-rich repeat-containing G protein-coupled receptor 4".
Further reading
- Hsu SY, Liang SG, Hsueh AJ (1999). "Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region". Mol. Endocrinol. 12 (12): 1830–45. doi:10.1210/me.12.12.1830. PMID 9849958.
- Loh ED, Broussard SR, Kolakowski LF (2001). "Molecular characterization of a novel glycoprotein hormone G-protein-coupled receptor". Biochem. Biophys. Res. Commun. 282 (3): 757–64. doi:10.1006/bbrc.2001.4625. PMID 11401528.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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