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{{Infobox gene}}
'''Retinoic acid-induced protein 3''' is a [[protein]] that in humans is encoded by the ''GPRC5A'' [[gene]].<ref name="pmid9857033">{{cite journal | vauthors = Cheng Y, Lotan R | title = Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor | journal = J. Biol. Chem. | volume = 273 | issue = 52 | pages = 35008–15 | year = 1998 | pmid = 9857033 | pmc =  | doi = 10.1074/jbc.273.52.35008 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GPRC5A G protein-coupled receptor, family C, group 5, member A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9052| accessdate = }}</ref>


== Function ==
This gene encodes a member of the type 3 [[G protein-coupled receptor]] family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between [[retinoic acid]] and [[G protein]] signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation.<ref name="entrez" />


<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
== Post transcriptional regulation ==
{{PBB_Controls
GPRC5A is one of only a handful of genes known in the literature that are post-transcriptionally controlled by [[miRNAs]] through their [[5'UTR]].<ref name="pmid24984703">{{cite journal | vauthors = Zhou H, Rigoutsos I | title = MiR-103a-3p targets the 5' UTR of GPRC5A in pancreatic cells | journal = RNA | volume = 20 | issue = 9 | pages = 1431–9 | year = 2014 | pmid = 24984703 | pmc = 4138326 | doi = 10.1261/rna.045757.114 }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==Clinical significance==
{{GNF_Protein_box
GPRC5A is dysregulated in many human cancers and in other diseases.<ref name="pmid25621293">{{cite journal | vauthors = Zhou H, Rigoutsos I | title = The emerging roles of GPRC5A in diseases | journal = Oncoscience | volume = 1 | issue = 12 | pages = 765–76 | year = 2014 | pmid = 25621293 | pmc = 4303886 | doi =  }}</ref>
| image =
| image_source =
| PDB =  
| Name = G protein-coupled receptor, family C, group 5, member A
| HGNCid = 9836
| Symbol = GPRC5A
| AltSymbols =; GPCR5A; RAI3; RAIG1
| OMIM = 604138
| ECnumber = 
| Homologene = 2961
| MGIid = 1891250
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0008067 |text = metabotropic glutamate, GABA-B-like receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9052
    | Hs_Ensembl = ENSG00000013588
    | Hs_RefseqProtein = NP_003970
    | Hs_RefseqmRNA = NM_003979
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 12934983
    | Hs_GenLoc_end = 12957833
    | Hs_Uniprot = Q8NFJ5
    | Mm_EntrezGene = 232431
    | Mm_Ensembl = ENSMUSG00000046733
    | Mm_RefseqmRNA = NM_181444
    | Mm_RefseqProtein = NP_852109
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 135031383
    | Mm_GenLoc_end = 135050402
    | Mm_Uniprot = Q8BHL4
  }}
}}
'''G protein-coupled receptor, family C, group 5, member A''', also known as '''GPRC5A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPRC5A G protein-coupled receptor, family C, group 5, member A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9052| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== See also ==
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation.<ref name="entrez">{{cite web | title = Entrez Gene: GPRC5A G protein-coupled receptor, family C, group 5, member A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9052| accessdate = }}</ref>
}}
 
==See also==
* [[Retinoic acid-inducible orphan G protein-coupled receptor]]
* [[Retinoic acid-inducible orphan G protein-coupled receptor]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Cafferata EG, Gonzalez-Guerrico AM, Pivetta OH, Santa-Coloma TA | title = Identification by differential display of a mRNA specifically induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in T84 human colon carcinoma cells | journal = Cell. Mol. Biol. (Noisy-le-grand) | volume = 42 | issue = 5 | pages = 797–804 | year = 1996 | pmid = 8832110 | doi =  }}
| citations =
* {{cite journal | vauthors = Bräuner-Osborne H, Krogsgaard-Larsen P | title = Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain | journal = Genomics | volume = 65 | issue = 2 | pages = 121–8 | year = 2000 | pmid = 10783259 | doi = 10.1006/geno.2000.6164 }}
*{{cite journal | author=Cafferata EG, Gonzalez-Guerrico AM, Pivetta OH, Santa-Coloma TA |title=Identification by differential display of a mRNA specifically induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in T84 human colon carcinoma cells. |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=42 |issue= 5 |pages= 797-804 |year= 1997 |pmid= 8832110 |doi=  }}
* {{cite journal | vauthors = Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN | title = Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C) | journal = Genomics | volume = 67 | issue = 1 | pages = 8–18 | year = 2000 | pmid = 10945465 | doi = 10.1006/geno.2000.6226 }}
*{{cite journal | author=Cheng Y, Lotan R |title=Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor. |journal=J. Biol. Chem. |volume=273 |issue= 52 |pages= 35008-15 |year= 1999 |pmid= 9857033 |doi=  }}
* {{cite journal | vauthors = Tao Q, Cheng Y, Clifford J, Lotan R | title = Characterization of the murine orphan G-protein-coupled receptor gene Rai3 and its regulation by retinoic acid | journal = Genomics | volume = 83 | issue = 2 | pages = 270–80 | year = 2004 | pmid = 14706456 | doi = 10.1016/S0888-7543(03)00237-4 }}
*{{cite journal  | author=Bräuner-Osborne H, Krogsgaard-Larsen P |title=Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain. |journal=Genomics |volume=65 |issue= 2 |pages= 121-8 |year= 2000 |pmid= 10783259 |doi= 10.1006/geno.2000.6164 }}
* {{cite journal | vauthors = Wu Q, Ding W, Mirza A, Van Arsdale T, Wei I, Bishop WR, Basso A, McClanahan T, Luo L, Kirschmeier P, Gustafson E, Hernandez M, Liu S | title = Integrative genomics revealed RAI3 is a cell growth-promoting gene and a novel P53 transcriptional target | journal = J. Biol. Chem. | volume = 280 | issue = 13 | pages = 12935–43 | year = 2005 | pmid = 15659406 | doi = 10.1074/jbc.M409901200 }}
*{{cite journal | author=Robbins MJ, Michalovich D, Hill J, ''et al.'' |title=Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C). |journal=Genomics |volume=67 |issue= 1 |pages= 8-18 |year= 2001 |pmid= 10945465 |doi= 10.1006/geno.2000.6226 }}
* {{cite journal | vauthors = Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, White FM | title = Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules | journal = Mol. Cell. Proteomics | volume = 4 | issue = 9 | pages = 1240–50 | year = 2005 | pmid = 15951569 | doi = 10.1074/mcp.M500089-MCP200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 14 | pages = 5391–6 | year = 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Hirano M, Zang L, Oka T, Ito Y, Shimada Y, Nishimura Y, Tanaka T | title = Novel reciprocal regulation of cAMP signaling and apoptosis by orphan G-protein-coupled receptor GPRC5A gene expression | journal = Biochem. Biophys. Res. Commun. | volume = 351 | issue = 1 | pages = 185–91 | year = 2006 | pmid = 17055459 | doi = 10.1016/j.bbrc.2006.10.016 }}
*{{cite journal  | author=Tao Q, Cheng Y, Clifford J, Lotan R |title=Characterization of the murine orphan G-protein-coupled receptor gene Rai3 and its regulation by retinoic acid. |journal=Genomics |volume=83 |issue= 2 |pages= 270-80 |year= 2004 |pmid= 14706456 |doi= }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Wu Q, Ding W, Mirza A, ''et al.'' |title=Integrative genomics revealed RAI3 is a cell growth-promoting gene and a novel P53 transcriptional target. |journal=J. Biol. Chem. |volume=280 |issue= 13 |pages= 12935-43 |year= 2005 |pmid= 15659406 |doi= 10.1074/jbc.M409901200 }}
*{{cite journal | author=Zhang Y, Wolf-Yadlin A, Ross PL, ''et al.'' |title=Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. |journal=Mol. Cell Proteomics |volume=4 |issue= 9 |pages= 1240-50 |year= 2005 |pmid= 15951569 |doi= 10.1074/mcp.M500089-MCP200 }}
*{{cite journal | author=Nousiainen M, Silljé HH, Sauer G, ''et al.'' |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391-6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 }}
*{{cite journal | author=Hirano M, Zang L, Oka T, ''et al.'' |title=Novel reciprocal regulation of cAMP signaling and apoptosis by orphan G-protein-coupled receptor GPRC5A gene expression. |journal=Biochem. Biophys. Res. Commun. |volume=351 |issue= 1 |pages= 185-91 |year= 2006 |pmid= 17055459 |doi= 10.1016/j.bbrc.2006.10.016 }}
}}
{{refend}}
{{refend}}
== External links ==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2959 | title = GPRC5 Receptors: RAIG<sub>1</sub> | accessdate = | author = | authorlink = | coauthors = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = | quote = }}


{{NLM content}}
{{NLM content}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors|g3}}
 
[[Category:G protein coupled receptors]]
[[Category:G protein coupled receptors]]


{{WH}}
 
{{WS}}
{{transmembranereceptor-stub}}

Revision as of 09:02, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Retinoic acid-induced protein 3 is a protein that in humans is encoded by the GPRC5A gene.[1][2]

Function

This gene encodes a member of the type 3 G protein-coupled receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoic acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation.[2]

Post transcriptional regulation

GPRC5A is one of only a handful of genes known in the literature that are post-transcriptionally controlled by miRNAs through their 5'UTR.[3]

Clinical significance

GPRC5A is dysregulated in many human cancers and in other diseases.[4]

See also

References

  1. ↑ Cheng Y, Lotan R (1998). "Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor". J. Biol. Chem. 273 (52): 35008–15. doi:10.1074/jbc.273.52.35008. PMID 9857033.
  2. ↑ 2.0 2.1 "Entrez Gene: GPRC5A G protein-coupled receptor, family C, group 5, member A".
  3. ↑ Zhou H, Rigoutsos I (2014). "MiR-103a-3p targets the 5' UTR of GPRC5A in pancreatic cells". RNA. 20 (9): 1431–9. doi:10.1261/rna.045757.114. PMC 4138326. PMID 24984703.
  4. ↑ Zhou H, Rigoutsos I (2014). "The emerging roles of GPRC5A in diseases". Oncoscience. 1 (12): 765–76. PMC 4303886. PMID 25621293.

Further reading

  • Cafferata EG, Gonzalez-Guerrico AM, Pivetta OH, Santa-Coloma TA (1996). "Identification by differential display of a mRNA specifically induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in T84 human colon carcinoma cells". Cell. Mol. Biol. (Noisy-le-grand). 42 (5): 797–804. PMID 8832110.
  • Bräuner-Osborne H, Krogsgaard-Larsen P (2000). "Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain". Genomics. 65 (2): 121–8. doi:10.1006/geno.2000.6164. PMID 10783259.
  • Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN (2000). "Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)". Genomics. 67 (1): 8–18. doi:10.1006/geno.2000.6226. PMID 10945465.
  • Tao Q, Cheng Y, Clifford J, Lotan R (2004). "Characterization of the murine orphan G-protein-coupled receptor gene Rai3 and its regulation by retinoic acid". Genomics. 83 (2): 270–80. doi:10.1016/S0888-7543(03)00237-4. PMID 14706456.
  • Wu Q, Ding W, Mirza A, Van Arsdale T, Wei I, Bishop WR, Basso A, McClanahan T, Luo L, Kirschmeier P, Gustafson E, Hernandez M, Liu S (2005). "Integrative genomics revealed RAI3 is a cell growth-promoting gene and a novel P53 transcriptional target". J. Biol. Chem. 280 (13): 12935–43. doi:10.1074/jbc.M409901200. PMID 15659406.
  • Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, White FM (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
  • Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Hirano M, Zang L, Oka T, Ito Y, Shimada Y, Nishimura Y, Tanaka T (2006). "Novel reciprocal regulation of cAMP signaling and apoptosis by orphan G-protein-coupled receptor GPRC5A gene expression". Biochem. Biophys. Res. Commun. 351 (1): 185–91. doi:10.1016/j.bbrc.2006.10.016. PMID 17055459.

External links

  • "GPRC5 Receptors: RAIG1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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