TAS2R10: Difference between revisions

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Revision as of 11:35, 15 September 2017

Taste receptor type 2 member 10 is a protein that in humans is encoded by the TAS2R10 gene.^[1]^[2]^[3]

Function

This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13.^[3]

TAS2R10 is also expressed in the smooth muscle of human airways, along with several other bitter taste receptors. Their activation in these cells causes an increase in intracellular calcium ion, which in turn triggers the opening of potassium channels which hyperpolarize the membrane and cause the smooth muscle to relax. Hence, activation of these receptors leads to bronchodilation.^[4]

References

↑ Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (Apr 2000). "A novel family of mammalian taste receptors". Cell. 100 (6): 693–702. doi:10.1016/S0092-8674(00)80705-9. PMID 10761934.
↑ Matsunami H, Montmayeur JP, Buck LB (Apr 2000). "A family of candidate taste receptors in human and mouse". Nature. 404 (6778): 601–4. doi:10.1038/35007072. PMID 10766242.
↑ ^3.0 ^3.1 "Entrez Gene: TAS2R10 taste receptor, type 2, member 10".
↑ Deshpande DA, Wang WC, McIlmoyle EL, Robinett KS, Schillinger RM, An SS, Sham JS, Liggett SB (November 2010). "Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction". Nat. Med. 16 (11): 1299–304. doi:10.1038/nm.2237. PMC 3066567. PMID 20972434.

Kinnamon SC (2000). "A plethora of taste receptors". Neuron. 25 (3): 507–10. doi:10.1016/S0896-6273(00)81054-5. PMID 10774719.
Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction". J. Biol. Chem. 277 (1): 1–4. doi:10.1074/jbc.R100054200. PMID 11696554.
Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol. 12 (4): 366–71. doi:10.1016/S0959-4388(02)00345-8. PMID 12139982.
Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ (2000). "T2Rs function as bitter taste receptors". Cell. 100 (6): 703–11. doi:10.1016/S0092-8674(00)80706-0. PMID 10761935.
Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell. 112 (3): 293–301. doi:10.1016/S0092-8674(03)00071-0. PMID 12581520.
Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes". Mol. Biol. Evol. 22 (3): 432–6. doi:10.1093/molbev/msi027. PMID 15496549.
Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates". Genetics. 170 (1): 313–26. doi:10.1534/genetics.104.037523. PMC 1449719. PMID 15744053.
Mueller KL, Hoon MA, Erlenbach I, Chandrashekar J, Zuker CS, Ryba NJ (2005). "The receptors and coding logic for bitter taste". Nature. 434 (7030): 225–9. doi:10.1038/nature03352. PMID 15759003.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

[pmid10761934-1] Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (Apr 2000). "A novel family of mammalian taste receptors". Cell. 100 (6): 693–702. doi:10.1016/S0092-8674(00)80705-9. PMID 10761934.

[pmid10766242-2] Matsunami H, Montmayeur JP, Buck LB (Apr 2000). "A family of candidate taste receptors in human and mouse". Nature. 404 (6778): 601–4. doi:10.1038/35007072. PMID 10766242.

[entrez-3] 3.0 ^3.1 "Entrez Gene: TAS2R10 taste receptor, type 2, member 10".

[pmid20972434-4] Deshpande DA, Wang WC, McIlmoyle EL, Robinett KS, Schillinger RM, An SS, Sham JS, Liggett SB (November 2010). "Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction". Nat. Med. 16 (11): 1299–304. doi:10.1038/nm.2237. PMC 3066567. PMID 20972434.

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[2]

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@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Taste receptor type 2 member 10''' is a [[protein]] that in humans is encoded by the ''TAS2R10'' [[gene]].<ref name="pmid10761934">{{cite journal | vauthors = Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS | title = A novel family of mammalian taste receptors | journal = Cell | volume = 100 | issue = 6 | pages = 693–702 | date = Apr 2000 | pmid = 10761934 | pmc =  | doi = 10.1016/S0092-8674(00)80705-9 }}</ref><ref name="pmid10766242">{{cite journal | vauthors = Matsunami H, Montmayeur JP, Buck LB | title = A family of candidate taste receptors in human and mouse | journal = Nature | volume = 404 | issue = 6778 | pages = 601–4 | date = Apr 2000 | pmid = 10766242 | pmc =  | doi = 10.1038/35007072 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TAS2R10 taste receptor, type 2, member 10| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50839| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Taste receptor, type 2, member 10
- | HGNCid = 14918
- | Symbol = TAS2R10
- | AltSymbols =; TRB2; MGC126811; MGC126813; T2R10
- | OMIM = 604791
- | ECnumber =
- | Homologene = 41540
- | MGIid = 2681207
- | GeneAtlas_image1 = PBB_GE_TAS2R10_221397_at_tn.png
- | Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0008527 |text = taste receptor activity}}
- | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
- | Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}} {{GNF_GO|id=GO:0050909 |text = sensory perception of taste}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 50839
-    | Hs_Ensembl = ENSG00000121318
-    | Hs_RefseqProtein = NP_076410
-    | Hs_RefseqmRNA = NM_023921
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 12
-    | Hs_GenLoc_start = 10869212
-    | Hs_GenLoc_end = 10870135
-    | Hs_Uniprot = Q9NYW0
-    | Mm_EntrezGene = 387342
-    | Mm_Ensembl = ENSMUSG00000053389
-    | Mm_RefseqmRNA = NM_199154
-    | Mm_RefseqProtein = NP_954605
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 6
-    | Mm_GenLoc_start = 131624851
-    | Mm_GenLoc_end = 131625777
-    | Mm_Uniprot = Q7M725
-  }}
-}}
-'''Taste receptor, type 2, member 10''', also known as '''TAS2R10''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TAS2R10 taste receptor, type 2, member 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50839| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+This gene product belongs to the family of candidate [[taste receptor]]s that are members of the [[G-protein-coupled receptor]] superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13.<ref name="entrez" />
-{{PBB_Summary
-| section_title =
+TAS2R10 is also expressed in the [[smooth muscle]] of human airways, along with several other bitter taste receptors. Their activation in these cells causes an increase in intracellular [[calcium ion]], which in turn triggers the opening of [[potassium channel]]s which [[hyperpolarization (biology)|hyperpolarize]] the membrane and cause the smooth muscle to relax. Hence, activation of these receptors leads to [[bronchodilation]].<ref name="pmid20972434">{{cite journal | vauthors = Deshpande DA, Wang WC, McIlmoyle EL, Robinett KS, Schillinger RM, An SS, Sham JS, Liggett SB | title = Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction | journal = Nat. Med. | volume = 16 | issue = 11 | pages = 1299–304 | date = November 2010 | pmid = 20972434 | pmc = 3066567 | doi = 10.1038/nm.2237 }}</ref>
-| summary_text = This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13.<ref name="entrez">{{cite web | title = Entrez Gene: TAS2R10 taste receptor, type 2, member 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50839| accessdate = }}</ref>
-}}
 ==See also==
@@ Line 58: / Line 12: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
-{{PBB_Further_reading
+*{{cite journal | author = Kinnamon SC | title = A plethora of taste receptors | journal = Neuron | volume = 25 | issue = 3 | pages = 507–10 | year = 2000 | pmid = 10774719 | doi = 10.1016/S0896-6273(00)81054-5 }}
-| citations =
+*{{cite journal | author = Margolskee RF | title = Molecular mechanisms of bitter and sweet taste transduction | journal = J. Biol. Chem. | volume = 277 | issue = 1 | pages = 1–4 | year = 2002 | pmid = 11696554 | doi = 10.1074/jbc.R100054200 }}
-*{{cite journal  | author=Kinnamon SC |title=A plethora of taste receptors. |journal=Neuron |volume=25 |issue= 3 |pages= 507-10 |year= 2000 |pmid= 10774719 |doi=  }}
+*{{cite journal | vauthors = Montmayeur JP, Matsunami H | title = Receptors for bitter and sweet taste | journal = Curr. Opin. Neurobiol. | volume = 12 | issue = 4 | pages = 366–71 | year = 2002 | pmid = 12139982 | doi = 10.1016/S0959-4388(02)00345-8 }}
-*{{cite journal  | author=Margolskee RF |title=Molecular mechanisms of bitter and sweet taste transduction. |journal=J. Biol. Chem. |volume=277 |issue= 1 |pages= 1-4 |year= 2002 |pmid= 11696554 |doi= 10.1074/jbc.R100054200 }}
+*{{cite journal | vauthors = Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ | title = T2Rs function as bitter taste receptors | journal = Cell | volume = 100 | issue = 6 | pages = 703–11 | year = 2000 | pmid = 10761935 | doi = 10.1016/S0092-8674(00)80706-0 }}
-*{{cite journal  | author=Montmayeur JP, Matsunami H |title=Receptors for bitter and sweet taste. |journal=Curr. Opin. Neurobiol. |volume=12 |issue= 4 |pages= 366-71 |year= 2002 |pmid= 12139982 |doi=  }}
+*{{cite journal | vauthors = Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ | title = Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways | journal = Cell | volume = 112 | issue = 3 | pages = 293–301 | year = 2003 | pmid = 12581520 | doi = 10.1016/S0092-8674(03)00071-0 }}
-*{{cite journal  | author=Adler E, Hoon MA, Mueller KL, ''et al.'' |title=A novel family of mammalian taste receptors. |journal=Cell |volume=100 |issue= 6 |pages= 693-702 |year= 2000 |pmid= 10761934 |doi=  }}
+*{{cite journal | vauthors = Fischer A, Gilad Y, Man O, Pääbo S | title = Evolution of bitter taste receptors in humans and apes | journal = Mol. Biol. Evol. | volume = 22 | issue = 3 | pages = 432–6 | year = 2005 | pmid = 15496549 | doi = 10.1093/molbev/msi027 }}
-*{{cite journal  | author=Chandrashekar J, Mueller KL, Hoon MA, ''et al.'' |title=T2Rs function as bitter taste receptors. |journal=Cell |volume=100 |issue= 6 |pages= 703-11 |year= 2000 |pmid= 10761935 |doi=  }}
+*{{cite journal | vauthors = Go Y, Satta Y, Takenaka O, Takahata N | title = Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates | journal = Genetics | volume = 170 | issue = 1 | pages = 313–26 | year = 2006 | pmid = 15744053 | pmc = 1449719 | doi = 10.1534/genetics.104.037523 }}
-*{{cite journal  | author=Matsunami H, Montmayeur JP, Buck LB |title=A family of candidate taste receptors in human and mouse. |journal=Nature |volume=404 |issue= 6778 |pages= 601-4 |year= 2000 |pmid= 10766242 |doi= 10.1038/35007072 }}
+*{{cite journal | vauthors = Mueller KL, Hoon MA, Erlenbach I, Chandrashekar J, Zuker CS, Ryba NJ | title = The receptors and coding logic for bitter taste | journal = Nature | volume = 434 | issue = 7030 | pages = 225–9 | year = 2005 | pmid = 15759003 | doi = 10.1038/nature03352 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
-*{{cite journal  | author=Zhang Y, Hoon MA, Chandrashekar J, ''et al.'' |title=Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. |journal=Cell |volume=112 |issue= 3 |pages= 293-301 |year= 2003 |pmid= 12581520 |doi=  }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-*{{cite journal  | author=Fischer A, Gilad Y, Man O, Pääbo S |title=Evolution of bitter taste receptors in humans and apes. |journal=Mol. Biol. Evol. |volume=22 |issue= 3 |pages= 432-6 |year= 2005 |pmid= 15496549 |doi= 10.1093/molbev/msi027 }}
-*{{cite journal  | author=Go Y, Satta Y, Takenaka O, Takahata N |title=Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. |journal=Genetics |volume=170 |issue= 1 |pages= 313-26 |year= 2006 |pmid= 15744053 |doi= 10.1534/genetics.104.037523 }}
-*{{cite journal  | author=Mueller KL, Hoon MA, Erlenbach I, ''et al.'' |title=The receptors and coding logic for bitter taste. |journal=Nature |volume=434 |issue= 7030 |pages= 225-9 |year= 2005 |pmid= 15759003 |doi= 10.1038/nature03352 }}
-}}
 {{refend}}
-{{membrane-protein-stub}}
 {{NLM content}}
-{{G protein-coupled receptors}}
+{{G protein-coupled receptors|g3}}
 [[Category:G protein coupled receptors]]
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TAS2R10: Difference between revisions

Revision as of 11:35, 15 September 2017

Contents

Function

See also

References

Further reading

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