TAS2R50: Difference between revisions

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{{Infobox_gene}}
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'''Taste receptor type 2 member 50''' is a [[protein]] that in humans is encoded by the ''TAS2R50'' [[gene]].<ref name="pmid12379855">{{cite journal | vauthors = Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W | title = The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides | journal = Nat Genet | volume = 32 | issue = 3 | pages = 397–401 | date = Oct 2002 | pmid = 12379855 | pmc =  | doi = 10.1038/ng1014 }}</ref><ref name="pmid12584440">{{cite journal | vauthors = Conte C, Ebeling M, Marcuz A, Nef P, Andres-Barquin PJ | title = Identification and characterization of human taste receptor genes belonging to the TAS2R family | journal = Cytogenet Genome Res | volume = 98 | issue = 1 | pages = 45–53 | date = Feb 2003 | pmid = 12584440 | pmc =  | doi = 10.1159/000068546 }}</ref><ref name="pmid16175505">{{cite journal | vauthors = Shiffman D, Ellis SG, Rowland CM, Malloy MJ, Luke MM, Iakoubova OA, Pullinger CR, Cassano J, Aouizerat BE, Fenwick RG, Reitz RE, Catanese JJ, Leong DU, Zellner C, Sninsky JJ, Topol EJ, Devlin JJ, Kane JP | title = Identification of Four Gene Variants Associated with Myocardial Infarction | journal = Am J Hum Genet | volume = 77 | issue = 4 | pages = 596–605 | date = Sep 2005 | pmid = 16175505 | pmc = 1275608 | doi = 10.1086/491674 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TAS2R50 taste receptor, type 2, member 50| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=259296| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Taste receptor, type 2, member 50
| HGNCid = 18882
| Symbol = TAS2R50
| AltSymbols =; MGC138305; T2R51
| OMIM = 609627
| ECnumber = 
| Homologene = 88474
| MGIid = 
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}} {{GNF_GO|id=GO:0050909 |text = sensory perception of taste}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 259296
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_795371
    | Hs_RefseqmRNA = NM_176890
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
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    | Mm_RefseqProtein = 
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    | Mm_GenLoc_chr = 
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'''Taste receptor, type 2, member 50''', also known as '''TAS2R50''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TAS2R50 taste receptor, type 2, member 50| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=259296| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
TAS2R50 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway.<ref name="pmid12584440" /> See also [[TAS2R10]].<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = TAS2R50 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002). See also TAS2R10 (MIM 604791).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: TAS2R50 taste receptor, type 2, member 50| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=259296| accessdate = }}</ref>
}}


==See also==
==See also==
Line 57: Line 10:


==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal | author = Margolskee RF | title = Molecular mechanisms of bitter and sweet taste transduction | journal = J. Biol. Chem. | volume = 277 | issue = 1 | pages = 1–4 | year = 2002 | pmid = 11696554 | doi = 10.1074/jbc.R100054200 }}
| citations =
*{{cite journal | vauthors = Montmayeur JP, Matsunami H | title = Receptors for bitter and sweet taste | journal = Curr. Opin. Neurobiol. | volume = 12 | issue = 4 | pages = 366–71 | year = 2002 | pmid = 12139982 | doi = 10.1016/S0959-4388(02)00345-8 }}
*{{cite journal | author=Margolskee RF |title=Molecular mechanisms of bitter and sweet taste transduction. |journal=J. Biol. Chem. |volume=277 |issue= 1 |pages= 1-4 |year= 2002 |pmid= 11696554 |doi= 10.1074/jbc.R100054200 }}
*{{cite journal | vauthors = Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ | title = Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways | journal = Cell | volume = 112 | issue = 3 | pages = 293–301 | year = 2003 | pmid = 12581520 | doi = 10.1016/S0092-8674(03)00071-0  }}
*{{cite journal | author=Montmayeur JP, Matsunami H |title=Receptors for bitter and sweet taste. |journal=Curr. Opin. Neurobiol. |volume=12 |issue= 4 |pages= 366-71 |year= 2002 |pmid= 12139982 |doi=  }}
*{{cite journal | vauthors = Fischer A, Gilad Y, Man O, Pääbo S | title = Evolution of bitter taste receptors in humans and apes | journal = Mol. Biol. Evol. | volume = 22 | issue = 3 | pages = 432–6 | year = 2005 | pmid = 15496549 | doi = 10.1093/molbev/msi027 }}
*{{cite journal  | author=Bufe B, Hofmann T, Krautwurst D, ''et al.'' |title=The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. |journal=Nat. Genet. |volume=32 |issue= 3 |pages= 397-401 |year= 2002 |pmid= 12379855 |doi= 10.1038/ng1014 }}
*{{cite journal | vauthors = Go Y, Satta Y, Takenaka O, Takahata N | title = Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates | journal = Genetics | volume = 170 | issue = 1 | pages = 313–26 | year = 2006 | pmid = 15744053 | pmc = 1449719 | doi = 10.1534/genetics.104.037523 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Zhang Y, Hoon MA, Chandrashekar J, ''et al.'' |title=Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. |journal=Cell |volume=112 |issue= 3 |pages= 293-301 |year= 2003 |pmid= 12581520 |doi=  }}
*{{cite journal  | author=Conte C, Ebeling M, Marcuz A, ''et al.'' |title=Identification and characterization of human taste receptor genes belonging to the TAS2R family. |journal=Cytogenet. Genome Res. |volume=98 |issue= 1 |pages= 45-53 |year= 2003 |pmid= 12584440 |doi= 10.1159/000068546 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Fischer A, Gilad Y, Man O, Pääbo S |title=Evolution of bitter taste receptors in humans and apes. |journal=Mol. Biol. Evol. |volume=22 |issue= 3 |pages= 432-6 |year= 2005 |pmid= 15496549 |doi= 10.1093/molbev/msi027 }}
*{{cite journal | author=Go Y, Satta Y, Takenaka O, Takahata N |title=Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. |journal=Genetics |volume=170 |issue= 1 |pages= 313-26 |year= 2006 |pmid= 15744053 |doi= 10.1534/genetics.104.037523 }}
*{{cite journal  | author=Shiffman D, Ellis SG, Rowland CM, ''et al.'' |title=Identification of four gene variants associated with myocardial infarction. |journal=Am. J. Hum. Genet. |volume=77 |issue= 4 |pages= 596-605 |year= 2005 |pmid= 16175505 |doi= 10.1086/491674 }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
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[[Category:G protein coupled receptors]]
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Revision as of 11:36, 15 September 2017

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Taste receptor type 2 member 50 is a protein that in humans is encoded by the TAS2R50 gene.[1][2][3][4]

Function

TAS2R50 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway.[2] See also TAS2R10.[4]

See also

References

  1. ↑ Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (Oct 2002). "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides". Nat Genet. 32 (3): 397–401. doi:10.1038/ng1014. PMID 12379855.
  2. ↑ 2.0 2.1 Conte C, Ebeling M, Marcuz A, Nef P, Andres-Barquin PJ (Feb 2003). "Identification and characterization of human taste receptor genes belonging to the TAS2R family". Cytogenet Genome Res. 98 (1): 45–53. doi:10.1159/000068546. PMID 12584440.
  3. ↑ Shiffman D, Ellis SG, Rowland CM, Malloy MJ, Luke MM, Iakoubova OA, Pullinger CR, Cassano J, Aouizerat BE, Fenwick RG, Reitz RE, Catanese JJ, Leong DU, Zellner C, Sninsky JJ, Topol EJ, Devlin JJ, Kane JP (Sep 2005). "Identification of Four Gene Variants Associated with Myocardial Infarction". Am J Hum Genet. 77 (4): 596–605. doi:10.1086/491674. PMC 1275608. PMID 16175505.
  4. ↑ 4.0 4.1 "Entrez Gene: TAS2R50 taste receptor, type 2, member 50".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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