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{{Infobox_gene}}
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'''G-protein coupled receptor 4''' is a [[protein]] that in humans is encoded by the ''GPR4'' [[gene]].<ref name="pmid8595909">{{cite journal |vauthors=Mahadevan MS, Baird S, Bailly JE, Shutler GG, Sabourin LA, Tsilfidis C, Neville CE, Narang M, Korneluk RG | title = Isolation of a novel G protein-coupled receptor (GPR4) localized to chromosome 19q13.3 | journal = Genomics | volume = 30 | issue = 1 | pages = 84–8 |date=Apr 1996 | pmid = 8595909 | pmc =  | doi = 10.1006/geno.1995.0013 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GPR4 G protein-coupled receptor 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2828| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = G protein-coupled receptor 4
| HGNCid = 4497
| Symbol = GPR4
| AltSymbols =;
| OMIM = 600551
| ECnumber =
| Homologene = 3867
| MGIid = 2441992
  | GeneAtlas_image1 = PBB_GE_GPR4_206236_at_tn.png
| GeneAtlas_image2 = PBB_GE_GPR4_211266_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2828
    | Hs_Ensembl = ENSG00000177464
    | Hs_RefseqProtein = NP_005273
    | Hs_RefseqmRNA = NM_005282
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 50784875
    | Hs_GenLoc_end = 50797294
    | Hs_Uniprot = P46093
    | Mm_EntrezGene = 319197
    | Mm_Ensembl = ENSMUSG00000044317
    | Mm_RefseqmRNA = NM_175668
    | Mm_RefseqProtein = NP_783599
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 18371060
    | Mm_GenLoc_end = 18382698
    | Mm_Uniprot = 
  }}
}}
'''G protein-coupled receptor 4''', also known as '''GPR4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPR4 G protein-coupled receptor 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2828| accessdate = }}</ref>


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==See also==
*[[Proton-sensing G protein-coupled receptors]]


==References==
==References==
{{reflist|2}}
{{Reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading
| citations =  
| citations =
*{{cite journal  | author=An S, Tsai C, Goetzl EJ |title=Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue. |journal=FEBS Lett. |volume=375 |issue= 1-2 |pages= 121-4 |year= 1996 |pmid= 7498459 |doi=  }}
*{{cite journal  |vauthors=An S, Tsai C, Goetzl EJ |title=Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue. |journal=FEBS Lett. |volume=375 |issue= 1–2 |pages= 121–4 |year= 1996 |pmid= 7498459 |doi=10.1016/0014-5793(95)01196-L }}
*{{cite journal  | author=Heiber M, Docherty JM, Shah G, ''et al.'' |title=Isolation of three novel human genes encoding G protein-coupled receptors. |journal=DNA Cell Biol. |volume=14 |issue= 1 |pages= 25-35 |year= 1995 |pmid= 7832990 |doi= }}
*{{cite journal  | author=Heiber M |title=Isolation of three novel human genes encoding G protein-coupled receptors |journal=DNA Cell Biol. |volume=14 |issue= 1 |pages= 25–35 |year= 1995 |pmid= 7832990 |doi=10.1089/dna.1995.14.25  |name-list-format=vanc| author2=Docherty JM  | author3=Shah G  | display-authors=3  | last4=Nguyen  | first4=Tuan  | last5=Cheng | first5=Regina  | last6=Heng  | first6=Henry H.Q. | last7=Marchese  | first7=Adriano  | last8=Tsui  | first8=LAP-Chee  | last9=Shi  | first9=Xiaomei  }}
*{{cite journal  | author=Mahadevan MS, Baird S, Bailly JE, ''et al.'' |title=Isolation of a novel G protein-coupled receptor (GPR4) localized to chromosome 19q13.3. |journal=Genomics |volume=30 |issue= 1 |pages= 84-8 |year= 1996 |pmid= 8595909 |doi= 10.1006/geno.1995.0013 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal | author=Zhu K, Baudhuin LM, Hong G, ''et al.'' |title=Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4. |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 41325-35 |year= 2001 |pmid= 11535583 |doi= 10.1074/jbc.M008057200 }}
*{{cite journal  | author=Lum H |title=Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=285 |issue= 4 |pages= H1786–9 |year= 2003 |pmid= 12805023 |doi= 10.1152/ajpheart.00359.2003 |name-list-format=vanc| author2=Qiao J  | author3=Walter RJ  | display-authors=3  | last4=Huang  | first4=F  | last5=Subbaiah  | first5=PV  | last6=Kim  | first6=KS  | last7=Holian  | first7=O }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ludwig MG |title=Proton-sensing G-protein-coupled receptors |journal=Nature |volume=425 |issue= 6953 |pages= 93–8 |year= 2003 |pmid= 12955148 |doi= 10.1038/nature01905 |name-list-format=vanc| author2=Vanek M  | author3=Guerini D  | display-authors=3  | last4=Gasser  | first4=Jürg A.  | last5=Jones  | first5=Carol E.  | last6=Junker  | first6=Uwe  | last7=Hofstetter  | first7=Hans  | last8=Wolf  | first8=Romain M.  | last9=Seuwen  | first9=Klaus }}
*{{cite journal  | author=Lum H, Qiao J, Walter RJ, ''et al.'' |title=Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells. |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=285 |issue= 4 |pages= H1786-9 |year= 2003 |pmid= 12805023 |doi= 10.1152/ajpheart.00359.2003 }}
*{{cite journal  | author=Bektas M |title=The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner |journal=Biochemistry |volume=42 |issue= 42 |pages= 12181–91 |year= 2003 |pmid= 14567679 |doi= 10.1021/bi035051y |name-list-format=vanc| author2=Barak LS  | author3=Jolly PS  | display-authors=3  | last4=Liu  | first4=Hong  | last5=Lynch  | first5=Kevin R.  | last6=Lacana  | first6=Emanuela  | last7=Suhr  | first7=Ki-Beom  | last8=Milstien  | first8=Sheldon  | last9=Spiegel  | first9=Sarah }}
*{{cite journal  | author=Ludwig MG, Vanek M, Guerini D, ''et al.'' |title=Proton-sensing G-protein-coupled receptors. |journal=Nature |volume=425 |issue= 6953 |pages= 93-8 |year= 2003 |pmid= 12955148 |doi= 10.1038/nature01905 }}
*{{cite journal  | author=Sin WC |title=G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers |journal=Oncogene |volume=23 |issue= 37 |pages= 6299–303 |year= 2004 |pmid= 15221007 |doi= 10.1038/sj.onc.1207838 |name-list-format=vanc| author2=Zhang Y  | author3=Zhong W  | display-authors=3  | last4=Adhikarakunnathu  | first4=Sree  | last5=Powers  | first5=Scott  | last6=Hoey  | first6=Tim  | last7=An  | first7=Songzhu  | last8=Yang  | first8=Jianxin }}
*{{cite journal  | author=Bektas M, Barak LS, Jolly PS, ''et al.'' |title=The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner. |journal=Biochemistry |volume=42 |issue= 42 |pages= 12181-91 |year= 2003 |pmid= 14567679 |doi= 10.1021/bi035051y }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Sin WC, Zhang Y, Zhong W, ''et al.'' |title=G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers. |journal=Oncogene |volume=23 |issue= 37 |pages= 6299-303 |year= 2004 |pmid= 15221007 |doi= 10.1038/sj.onc.1207838 }}
*{{cite journal  | author=Kim KS |title=GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine |journal=FASEB J. |volume=19 |issue= 7 |pages= 819–21 |year= 2005 |pmid= 15857892 |doi= 10.1096/fj.04-2988fje |name-list-format=vanc| author2=Ren J  | author3=Jiang Y  | display-authors=3  | last4=Ebrahem  | first4=Q  | last5=Tipps  | first5=R  | last6=Cristina  | first6=K  | last7=Xiao  | first7=YJ  | last8=Qiao  | first8=J  | last9=Taylor  | first9=KL }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Qiao J |title=Lysophosphatidylcholine impairs endothelial barrier function through the G protein-coupled receptor GPR4 |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=291 |issue= 1 |pages= L91–101 |year= 2006 |pmid= 16461426 |doi= 10.1152/ajplung.00508.2005 |name-list-format=vanc| author2=Huang F  | author3=Naikawadi RP  | display-authors=3  | last4=Kim  | first4=KS  | last5=Said  | first5=T  | last6=Lum  | first6=H }}
*{{cite journal  | author=Kim KS, Ren J, Jiang Y, ''et al.'' |title=GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine. |journal=FASEB J. |volume=19 |issue= 7 |pages= 819-21 |year= 2005 |pmid= 15857892 |doi= 10.1096/fj.04-2988fje }}
*{{cite journal  | author=Huang F |title=A novel lysophospholipid- and pH-sensitive receptor, GPR4, in brain endothelial cells regulates monocyte transmigration |journal=Endothelium |volume=14 |issue= 1 |pages= 25–34 |year= 2007 |pmid= 17364894 |doi= 10.1080/10623320601177288 |name-list-format=vanc| author2=Mehta D  | author3=Predescu S  | display-authors=3  | last4=Kim  | first4=Kwang  | last5=Lum  | first5=Hazel }}
*{{cite journal  | author=Qiao J, Huang F, Naikawadi RP, ''et al.'' |title=Lysophosphatidylcholine impairs endothelial barrier function through the G protein-coupled receptor GPR4. |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=291 |issue= 1 |pages= L91-101 |year= 2006 |pmid= 16461426 |doi= 10.1152/ajplung.00508.2005 }}
*{{cite journal  | author=Zou Y |title=Upregulation of endothelial adhesion molecules by lysophosphatidylcholine. Involvement of G protein-coupled receptor GPR4 |journal=FEBS J. |volume=274 |issue= 10 |pages= 2573–84 |year= 2007 |pmid= 17437524 |doi= 10.1111/j.1742-4658.2007.05792.x |name-list-format=vanc| author2=Kim CH  | author3=Chung JH  | display-authors=3  | last4=Kim  | first4=Ji Y.  | last5=Chung  | first5=Sang W.  | last6=Kim  | first6=Mi K.  | last7=Im  | first7=Dong S.  | last8=Lee  | first8=Jaewon  | last9=Yu  | first9=Byung P. }}
*{{cite journal  | author=Huang F, Mehta D, Predescu S, ''et al.'' |title=A novel lysophospholipid- and pH-sensitive receptor, GPR4, in brain endothelial cells regulates monocyte transmigration. |journal=Endothelium |volume=14 |issue= 1 |pages= 25-34 |year= 2007 |pmid= 17364894 |doi= 10.1080/10623320601177288 }}
*{{cite journal  | author=Tobo M |title=Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms |journal=Cell. Signal. |volume=19 |issue= 8 |pages= 1745–53 |year= 2007 |pmid= 17462861 |doi= 10.1016/j.cellsig.2007.03.009 |name-list-format=vanc| author2=Tomura H  | author3=Mogi C  | display-authors=3  | last4=Wang  | first4=J  | last5=Liu  | first5=J  | last6=Komachi  | first6=M  | last7=Damirin  | first7=A  | last8=Kimura  | first8=T  | last9=Murata  | first9=N }}
*{{cite journal  | author=Zou Y, Kim CH, Chung JH, ''et al.'' |title=Upregulation of endothelial adhesion molecules by lysophosphatidylcholine. Involvement of G protein-coupled receptor GPR4. |journal=FEBS J. |volume=274 |issue= 10 |pages= 2573-84 |year= 2007 |pmid= 17437524 |doi= 10.1111/j.1742-4658.2007.05792.x }}
*{{cite journal  | author=Tobo M, Tomura H, Mogi C, ''et al.'' |title=Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms. |journal=Cell. Signal. |volume=19 |issue= 8 |pages= 1745-53 |year= 2007 |pmid= 17462861 |doi= 10.1016/j.cellsig.2007.03.009 }}
}}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
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[[Category:G protein coupled receptors]]
[[Category:G protein coupled receptors]]
{{WikiDoc Sources}}
 
 
{{Transmembranereceptor-stub}}

Revision as of 09:00, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

G-protein coupled receptor 4 is a protein that in humans is encoded by the GPR4 gene.[1][2]


See also

References

  1. ↑ Mahadevan MS, Baird S, Bailly JE, Shutler GG, Sabourin LA, Tsilfidis C, Neville CE, Narang M, Korneluk RG (Apr 1996). "Isolation of a novel G protein-coupled receptor (GPR4) localized to chromosome 19q13.3". Genomics. 30 (1): 84–8. doi:10.1006/geno.1995.0013. PMID 8595909.
  2. ↑ "Entrez Gene: GPR4 G protein-coupled receptor 4".

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=GPR4&oldid=1418806"