VN1R1: Difference between revisions

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Revision as of 15:36, 17 September 2017

Vomeronasal type-1 receptor 1 is a protein that in humans is encoded by the VN1R1 gene.^[1]^[2]

Pheromones are chemical signals that elicit specific behavioral responses and physiologic alterations in recipients of the same species. The protein encoded by this gene is similar to pheromone receptors and is primarily localized to the olfactory mucosa. An alternate splice variant of this gene is thought to exist, but its full length nature has not been determined.^[2]

References

↑ Rodriguez I, Greer CA, Mok MY, Mombaerts P (Oct 2000). "A putative pheromone receptor gene expressed in human olfactory mucosa". Nat Genet. 26 (1): 18–9. doi:10.1038/79124. PMID 10973240.
↑ ^2.0 ^2.1 "Entrez Gene: VN1R1 vomeronasal 1 receptor 1".

Giorgi D, Friedman C, Trask BJ, Rouquier S (2001). "Characterization of nonfunctional V1R-like pheromone receptor sequences in human". Genome Res. 10 (12): 1979–85. doi:10.1101/gr.10.12.1979. PMC 313059. PMID 11116092.
Pantages E, Dulac C (2001). "A novel family of candidate pheromone receptors in mammals". Neuron. 28 (3): 835–45. doi:10.1016/S0896-6273(00)00157-4. PMID 11163270.
Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhang J, Webb DM (2003). "Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates". Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8337–41. doi:10.1073/pnas.1331721100. PMC 166230. PMID 12826614.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Mitropoulos C, Papachatzopoulou A, Menounos PG, et al. (2007). "Association study of human VN1R1 pheromone receptor gene alleles and gender". Genet. Test. 11 (2): 128–32. doi:10.1089/gte.2006.0516. PMID 17627382.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

[pmid10973240-1] Rodriguez I, Greer CA, Mok MY, Mombaerts P (Oct 2000). "A putative pheromone receptor gene expressed in human olfactory mucosa". Nat Genet. 26 (1): 18–9. doi:10.1038/79124. PMID 10973240.

[entrez-2] 2.0 ^2.1 "Entrez Gene: VN1R1 vomeronasal 1 receptor 1".

[1]

[2]

@@ Line 1: / Line 1: @@
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+{{Underlinked|date=June 2016}}
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+'''Vomeronasal type-1 receptor 1''' is a [[protein]] that in humans is encoded by the ''VN1R1'' [[gene]].<ref name="pmid10973240">{{cite journal | vauthors = Rodriguez I, Greer CA, Mok MY, Mombaerts P | title = A putative pheromone receptor gene expressed in human olfactory mucosa | journal = Nat Genet | volume = 26 | issue = 1 | pages = 18–9 |date=Oct 2000 | pmid = 10973240 | pmc =  | doi = 10.1038/79124 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: VN1R1 vomeronasal 1 receptor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57191| accessdate = }}</ref>
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- | image =
- | image_source =
- | PDB =
- | Name = Vomeronasal 1 receptor 1
- | HGNCid = 13548
- | Symbol = VN1R1
- | AltSymbols =; V1RL1; VNR19I1; ZVNH1; ZVNR1
- | OMIM = 605234
- | ECnumber =
- | Homologene = 74336
- | MGIid =
- | GeneAtlas_image1 = PBB_GE_VN1R1_221412_at_tn.png
- | Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0016503 |text = pheromone receptor activity}}
- | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
- | Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0019236 |text = response to pheromone}}
-  | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 57191
-    | Hs_Ensembl = ENSG00000178201
-    | Hs_RefseqProtein = NP_065684
-    | Hs_RefseqmRNA = NM_020633
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 19
-    | Hs_GenLoc_start = 62658605
-    | Hs_GenLoc_end = 62659666
-    | Hs_Uniprot = Q9GZP7
-    | Mm_EntrezGene =
-    | Mm_Ensembl =
-    | Mm_RefseqmRNA =
-    | Mm_RefseqProtein =
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-    | Mm_GenLoc_chr =
-    | Mm_GenLoc_start =
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-  }}
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-'''Vomeronasal 1 receptor 1''', also known as '''VN1R1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: VN1R1 vomeronasal 1 receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57191| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
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-| summary_text = Pheromones are chemical signals that elicit specific behavioral responses and physiologic alterations in recipients of the same species. The protein encoded by this gene is similar to pheromone receptors and is primarily localized to the olfactory mucosa. An alternate splice variant of this gene is thought to exist, but its full length nature has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: VN1R1 vomeronasal 1 receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57191| accessdate = }}</ref>
+| summary_text = Pheromones are chemical signals that elicit specific behavioral responses and physiologic alterations in recipients of the same species. The protein encoded by this gene is similar to pheromone receptors and is primarily localized to the olfactory mucosa. An alternate splice variant of this gene is thought to exist, but its full length nature has not been determined.<ref name="entrez" />
 }}
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Rodriguez I, Greer CA, Mok MY, Mombaerts P |title=A putative pheromone receptor gene expressed in human olfactory mucosa. |journal=Nat. Genet. |volume=26 |issue= 1 |pages= 18-9 |year= 2000 |pmid= 10973240 |doi= 10.1038/79124 }}
+*{{cite journal  | vauthors=Giorgi D, Friedman C, Trask BJ, Rouquier S |title=Characterization of nonfunctional V1R-like pheromone receptor sequences in human |journal=Genome Res. |volume=10 |issue= 12 |pages= 1979–85 |year= 2001 |pmid= 11116092 |doi=10.1101/gr.10.12.1979  | pmc=313059  }}
-*{{cite journal  | author=Giorgi D, Friedman C, Trask BJ, Rouquier S |title=Characterization of nonfunctional V1R-like pheromone receptor sequences in human. |journal=Genome Res. |volume=10 |issue= 12 |pages= 1979-85 |year= 2001 |pmid= 11116092 |doi=  }}
+*{{cite journal  | vauthors=Pantages E, Dulac C |title=A novel family of candidate pheromone receptors in mammals |journal=Neuron |volume=28 |issue= 3 |pages= 835–45 |year= 2001 |pmid= 11163270 |doi=10.1016/S0896-6273(00)00157-4  }}
-*{{cite journal  | author=Pantages E, Dulac C |title=A novel family of candidate pheromone receptors in mammals. |journal=Neuron |volume=28 |issue= 3 |pages= 835-45 |year= 2001 |pmid= 11163270 |doi=  }}
+*{{cite journal   |vauthors=Takeda S, Kadowaki S, Haga T, etal |title=Identification of G protein-coupled receptor genes from the human genome sequence |journal=FEBS Lett. |volume=520 |issue= 1–3 |pages= 97–101 |year= 2002 |pmid= 12044878 |doi=10.1016/S0014-5793(02)02775-8  }}
-*{{cite journal  | author=Takeda S, Kadowaki S, Haga T, ''et al.'' |title=Identification of G protein-coupled receptor genes from the human genome sequence. |journal=FEBS Lett. |volume=520 |issue= 1-3 |pages= 97-101 |year= 2002 |pmid= 12044878 |doi=  }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | vauthors=Zhang J, Webb DM |title=Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 14 |pages= 8337–41 |year= 2003 |pmid= 12826614 |doi= 10.1073/pnas.1331721100  | pmc=166230 }}
-*{{cite journal  | author=Zhang J, Webb DM |title=Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 14 |pages= 8337-41 |year= 2003 |pmid= 12826614 |doi= 10.1073/pnas.1331721100 }}
+*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal   |vauthors=Mitropoulos C, Papachatzopoulou A, Menounos PG, etal |title=Association study of human VN1R1 pheromone receptor gene alleles and gender |journal=Genet. Test. |volume=11 |issue= 2 |pages= 128–32 |year= 2007 |pmid= 17627382 |doi= 10.1089/gte.2006.0516 }}
-*{{cite journal  | author=Mitropoulos C, Papachatzopoulou A, Menounos PG, ''et al.'' |title=Association study of human VN1R1 pheromone receptor gene alleles and gender. |journal=Genet. Test. |volume=11 |issue= 2 |pages= 128-32 |year= 2007 |pmid= 17627382 |doi= 10.1089/gte.2006.0516 }}
 }}
 {{refend}}
-{{membrane-protein-stub}}
 {{NLM content}}
 {{G protein-coupled receptors}}
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 [[Category:G protein coupled receptors]]
-{{WikiDoc Sources}}
+{{transmembranereceptor-stub}}

VN1R1: Difference between revisions

Revision as of 15:36, 17 September 2017

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