P2RY11: Difference between revisions

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{{Infobox_gene}}
 
'''P2Y purinoceptor 11''' is a [[protein]] that in humans is encoded by the ''P2RY11'' [[gene]].<ref name="pmid9405388">{{cite journal |vauthors=Communi D, Govaerts C, Parmentier M, Boeynaems JM | title = Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase | journal = J Biol Chem | volume = 272 | issue = 51 | pages = 31969–73 |date=Jan 1998 | pmid = 9405388 | pmc =  | doi =10.1074/jbc.272.51.31969 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: P2RY11 purinergic receptor P2Y, G-protein coupled, 11| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5032| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Purinergic receptor P2Y, G-protein coupled, 11
| HGNCid = 8540
| Symbol = P2RY11
| AltSymbols =; P2Y11
| OMIM = 602697
| ECnumber = 
| Homologene = 
| MGIid = 
| GeneAtlas_image1 = PBB_GE_P2RY11_214546_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0045028 |text = purinergic nucleotide receptor activity, G-protein coupled}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007190 |text = adenylate cyclase activation}} {{GNF_GO|id=GO:0007200 |text = G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5032
    | Hs_Ensembl = ENSG00000176130
    | Hs_RefseqProtein = NP_002557
    | Hs_RefseqmRNA = NM_002566
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 10083197
    | Hs_GenLoc_end = 10087065
    | Hs_Uniprot = Q96G91
    | Mm_EntrezGene =
    | Mm_Ensembl =   
    | Mm_RefseqmRNA =   
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Purinergic receptor P2Y, G-protein coupled, 11''', also known as '''P2RY11''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: P2RY11 purinergic receptor P2Y, G-protein coupled, 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5032| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occurring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product.<ref name="entrez">{{cite web | title = Entrez Gene: P2RY11 purinergic receptor P2Y, G-protein coupled, 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5032| accessdate = }}</ref>
| summary_text = The product of this gene, P2Y<sub>11</sub>, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occurring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product.<ref name="entrez" />
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2400 | title = P2Y Receptors: P2Y<sub>11</sub> | accessdate = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=van der Weyden L, Conigrave AD, Morris MB |title=Signal transduction and white cell maturation via extracellular ATP and the P2Y11 receptor. |journal=Immunol. Cell Biol. |volume=78 |issue= 4 |pages= 369-74 |year= 2000 |pmid= 10947861 |doi=  }}
*{{cite journal  |vauthors=van der Weyden L, Conigrave AD, Morris MB |title=Signal transduction and white cell maturation via extracellular ATP and the P2Y11 receptor |journal=Immunol. Cell Biol. |volume=78 |issue= 4 |pages= 369–74 |year= 2000 |pmid= 10947861 |doi=10.1046/j.1440-1711.2000.00918.x }}
*{{cite journal  | author=Adams MD, Kerlavage AR, Fleischmann RD, ''et al.'' |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3-174 |year= 1995 |pmid= 7566098 |doi=  }}
*{{cite journal  | author=Adams MD |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3–174 |year= 1995 |pmid= 7566098 |doi=<!-- none available --> |url=http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf | format=PDF  |name-list-format=vanc| author2=Kerlavage AR | author3=Fleischmann RD  | display-authors=3  | last4=Fuldner  | first4=RA | last5=Bult  | first5=CJ  | last6=Lee  | first6=NH  | last7=Kirkness  | first7=EF  | last8=Weinstock  | first8=KG  | last9=Gocayne | first9=JD  }}
*{{cite journal | author=Communi D, Govaerts C, Parmentier M, Boeynaems JM |title=Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase. |journal=J. Biol. Chem. |volume=272 |issue= 51 |pages= 31969-73 |year= 1998 |pmid= 9405388 |doi=  }}
*{{cite journal  | author=Communi D |title=Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes |journal=J. Biol. Chem. |volume=276 |issue= 19 |pages= 16561–6 |year= 2001 |pmid= 11278528 |doi= 10.1074/jbc.M009609200 |name-list-format=vanc| author2=Suarez-Huerta N  | author3=Dussossoy D  | display-authors=3  | last4=Savi  | first4=P  | last5=Boeynaems  | first5=JM }}
*{{cite journal  | author=Communi D, Suarez-Huerta N, Dussossoy D, ''et al.'' |title=Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes. |journal=J. Biol. Chem. |volume=276 |issue= 19 |pages= 16561-6 |year= 2001 |pmid= 11278528 |doi= 10.1074/jbc.M009609200 }}
*{{cite journal  | author=Moore DJ |title=Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study |journal=Biochim. Biophys. Acta |volume=1521 |issue= 1–3 |pages= 107–19 |year= 2001 |pmid= 11690642 |doi= 10.1016/S0167-4781(01)00291-3|name-list-format=vanc| author2=Chambers JK  | author3=Wahlin JP  | display-authors=3  | last4=Tan  | first4=KB  | last5=Moore  | first5=GB  | last6=Jenkins  | first6=O  | last7=Emson  | first7=PC  | last8=Murdock  | first8=PR }}
*{{cite journal  | author=Moore DJ, Chambers JK, Wahlin JP, ''et al.'' |title=Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study. |journal=Biochim. Biophys. Acta |volume=1521 |issue= 1-3 |pages= 107-19 |year= 2001 |pmid= 11690642 |doi=  }}
*{{cite journal  | author=Duhant X |title=Extracellular adenine nucleotides inhibit the activation of human CD4+ T lymphocytes |journal=J. Immunol. |volume=169 |issue= 1 |pages= 15–21 |year= 2002 |pmid= 12077223 |doi= 10.4049/jimmunol.169.1.15|name-list-format=vanc| author2=Schandené L  | author3=Bruyns C  | display-authors=3  | last4=Gonzalez  | first4=NS  | last5=Goldman  | first5=M  | last6=Boeynaems  | first6=JM  | last7=Communi  | first7=D }}
*{{cite journal  | author=Duhant X, Schandené L, Bruyns C, ''et al.'' |title=Extracellular adenine nucleotides inhibit the activation of human CD4+ T lymphocytes. |journal=J. Immunol. |volume=169 |issue= 1 |pages= 15-21 |year= 2002 |pmid= 12077223 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Moreschi I |title=Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes |journal=J. Biol. Chem. |volume=281 |issue= 42 |pages= 31419–29 |year= 2006 |pmid= 16926152 |doi= 10.1074/jbc.M606625200 |name-list-format=vanc| author2=Bruzzone S  | author3=Nicholas RA  | display-authors=3  | last4=Fruscione  | first4=F.  | last5=Sturla  | first5=L.  | last6=Benvenuto  | first6=F.  | last7=Usai  | first7=C.  | last8=Meis  | first8=S.  | last9=Kassack  | first9=M. U. }}
*{{cite journal  | author=Moreschi I, Bruzzone S, Nicholas RA, ''et al.'' |title=Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes. |journal=J. Biol. Chem. |volume=281 |issue= 42 |pages= 31419-29 |year= 2006 |pmid= 16926152 |doi= 10.1074/jbc.M606625200 }}
*{{cite journal  |vauthors=Zylberg J, Ecke D, Fischer B, Reiser G |title=Structure and ligand-binding site characteristics of the human P2Y11 nucleotide receptor deduced from computational modelling and mutational analysis |journal=Biochem. J. |volume=405 |issue= 2 |pages= 277–86 |year= 2007 |pmid= 17338680 |doi= 10.1042/BJ20061728 | pmc=1904521 }}
*{{cite journal  | author=Zylberg J, Ecke D, Fischer B, Reiser G |title=Structure and ligand-binding site characteristics of the human P2Y11 nucleotide receptor deduced from computational modelling and mutational analysis. |journal=Biochem. J. |volume=405 |issue= 2 |pages= 277-86 |year= 2007 |pmid= 17338680 |doi= 10.1042/BJ20061728 }}
}}
}}
{{refend}}
{{refend}}
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{{NLM content}}
{{NLM content}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
{{Purinergics}}
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[[Category:G protein coupled receptors]]
[[Category:G protein coupled receptors]]


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{{WS}}
{{transmembranereceptor-stub}}

Revision as of 17:26, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

P2Y purinoceptor 11 is a protein that in humans is encoded by the P2RY11 gene.[1][2]

The product of this gene, P2Y11, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occurring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product.[2]

See also

References

  1. ↑ Communi D, Govaerts C, Parmentier M, Boeynaems JM (Jan 1998). "Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase". J Biol Chem. 272 (51): 31969–73. doi:10.1074/jbc.272.51.31969. PMID 9405388.
  2. ↑ 2.0 2.1 "Entrez Gene: P2RY11 purinergic receptor P2Y, G-protein coupled, 11".

External links

  • "P2Y Receptors: P2Y11". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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