Neuromedin U receptor 2: Difference between revisions

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{{Infobox_gene}}
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'''Neuromedin-U receptor 2''' is a [[protein]] that in humans is encoded by the ''NMUR2'' [[gene]].<ref name="pmid8940772">{{cite journal |vauthors=Tate CG, Grisshammer R | title = Heterologous expression of G-protein-coupled receptors | journal = Trends Biotechnol | volume = 14 | issue = 11 | pages = 426–30 |date=Jan 1997 | pmid = 8940772 | pmc =  | doi = 10.1016/0167-7799(96)10059-7 }}</ref><ref name="pmid10894543">{{cite journal |vauthors=Howard AD, Wang R, Pong SS, Mellin TN, Strack A, Guan XM, Zeng Z, ((Williams DL Jr)), Feighner SD, Nunes CN, Murphy B, Stair JN, Yu H, Jiang Q, Clements MK, Tan CP, McKee KK, Hreniuk DL, McDonald TP, Lynch KR, Evans JF, Austin CP, Caskey CT, Van der Ploeg LH, Liu Q | title = Identification of receptors for neuromedin U and its role in feeding | journal = Nature | volume = 406 | issue = 6791 | pages = 70–4 |date=Jul 2000 | pmid = 10894543 | pmc =  | doi = 10.1038/35017610 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NMUR2 neuromedin U receptor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56923| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Neuromedin U receptor 2
| HGNCid = 16454
| Symbol = NMUR2
| AltSymbols =; FM4; NMU2R
| OMIM = 605108
| ECnumber = 
| Homologene = 49618
| MGIid = 2441765
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0001607 |text = neuromedin U receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005229 |text = intracellular calcium activated chloride channel activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
  | Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006816 |text = calcium ion transport}} {{GNF_GO|id=GO:0006940 |text = regulation of smooth muscle contraction}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007200 |text = G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)}} {{GNF_GO|id=GO:0007204 |text = elevation of cytosolic calcium ion concentration}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}} {{GNF_GO|id=GO:0007417 |text = central nervous system development}} {{GNF_GO|id=GO:0007631 |text = feeding behavior}} {{GNF_GO|id=GO:0019226 |text = transmission of nerve impulse}} {{GNF_GO|id=GO:0043006 |text = calcium-dependent phospholipase A2 activation}} {{GNF_GO|id=GO:0045045 |text = secretory pathway}} {{GNF_GO|id=GO:0048016 |text = inositol phosphate-mediated signaling}} {{GNF_GO|id=GO:0050482 |text = arachidonic acid secretion}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 56923
    | Hs_Ensembl = ENSG00000132911
    | Hs_RefseqProtein = NP_064552
    | Hs_RefseqmRNA = NM_020167
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 151751303
    | Hs_GenLoc_end = 151765017
    | Hs_Uniprot = Q9GZQ4
    | Mm_EntrezGene = 216749
    | Mm_Ensembl = ENSMUSG00000037393
    | Mm_RefseqmRNA = NM_153079
    | Mm_RefseqProtein = NP_694719
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 55868413
    | Mm_GenLoc_end = 55884410
    | Mm_Uniprot = Q8BZ39
  }}
}}
'''Neuromedin U receptor 2''', also known as '''NMUR2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NMUR2 neuromedin U receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56923| accessdate = }}</ref>


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==Ligands==
===Agonists===
* [[synephrine]]<ref>{{cite journal|journal=Biol Pharm Bull|pmid=24598981|accessdate=7 July 2016 | volume=37|title=p-Synephrine: a novel agonist for neuromedin U2 receptor|year=2014|pages=764–70|vauthors=Zheng X, Guo L, Wang D, Deng X|doi=10.1248/bpb.b13-00788}}</ref>


==See also==
==See also==
Line 57: Line 17:


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2899 | title = Neuromedin U Receptors: NMU2 | accessdate = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}


==Further reading==
==Further reading==
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| citations =  
| citations =  
*{{cite journal | author=Tate CG, Grisshammer R |title=Heterologous expression of G-protein-coupled receptors. |journal=Trends Biotechnol. |volume=14 |issue= 11 |pages= 426-30 |year= 1997 |pmid= 8940772 |doi= 10.1016/0167-7799(96)10059-7 }}
*{{cite journal   |vauthors=Hosoya M, Moriya T, Kawamata Y, etal |title=Identification and functional characterization of a novel subtype of neuromedin U receptor. |journal=J. Biol. Chem. |volume=275 |issue= 38 |pages= 29528–32 |year= 2000 |pmid= 10887190 |doi= 10.1074/jbc.M004261200 }}
*{{cite journal  | author=Hosoya M, Moriya T, Kawamata Y, ''et al.'' |title=Identification and functional characterization of a novel subtype of neuromedin U receptor. |journal=J. Biol. Chem. |volume=275 |issue= 38 |pages= 29528-32 |year= 2000 |pmid= 10887190 |doi= 10.1074/jbc.M004261200 }}
*{{cite journal   |vauthors=Raddatz R, Wilson AE, Artymyshyn R, etal |title=Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system. |journal=J. Biol. Chem. |volume=275 |issue= 42 |pages= 32452–9 |year= 2000 |pmid= 10899166 |doi= 10.1074/jbc.M004613200 }}
*{{cite journal | author=Howard AD, Wang R, Pong SS, ''et al.'' |title=Identification of receptors for neuromedin U and its role in feeding. |journal=Nature |volume=406 |issue= 6791 |pages= 70-4 |year= 2000 |pmid= 10894543 |doi= 10.1038/35017610 }}
*{{cite journal   |vauthors=Shan L, Qiao X, Crona JH, etal |title=Identification of a novel neuromedin U receptor subtype expressed in the central nervous system. |journal=J. Biol. Chem. |volume=275 |issue= 50 |pages= 39482–6 |year= 2001 |pmid= 11010960 |doi= 10.1074/jbc.C000522200 }}
*{{cite journal  | author=Raddatz R, Wilson AE, Artymyshyn R, ''et al.'' |title=Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system. |journal=J. Biol. Chem. |volume=275 |issue= 42 |pages= 32452-9 |year= 2000 |pmid= 10899166 |doi= 10.1074/jbc.M004613200 }}
*{{cite journal  |vauthors=Fernández Alvarez C, Debeljuk L, Díaz Rodríguez E, Díaz López B |title=Developmental pattern of tachykinins during aging in several organs: effect of exogenous melatonin. |journal=Peptides |volume=23 |issue= 9 |pages= 1617–23 |year= 2003 |pmid= 12217422 |doi=10.1016/S0196-9781(02)00099-2 }}
*{{cite journal | author=Shan L, Qiao X, Crona JH, ''et al.'' |title=Identification of a novel neuromedin U receptor subtype expressed in the central nervous system. |journal=J. Biol. Chem. |volume=275 |issue= 50 |pages= 39482-6 |year= 2001 |pmid= 11010960 |doi= 10.1074/jbc.C000522200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Fernández Alvarez C, Debeljuk L, Díaz Rodríguez E, Díaz López B |title=Developmental pattern of tachykinins during aging in several organs: effect of exogenous melatonin. |journal=Peptides |volume=23 |issue= 9 |pages= 1617-23 |year= 2003 |pmid= 12217422 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Bhattacharyya S, Luan J, Farooqi IS, etal |title=Studies of the neuromedin U-2 receptor gene in human obesity: evidence for the existence of two ancestral forms of the receptor. |journal=J. Endocrinol. |volume=183 |issue= 1 |pages= 115–20 |year= 2004 |pmid= 15525579 |doi= 10.1677/joe.1.05830 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Mori K, Miyazato M, Ida T, etal |title=Identification of neuromedin S and its possible role in the mammalian circadian oscillator system. |journal=EMBO J. |volume=24 |issue= 2 |pages= 325–35 |year= 2005 |pmid= 15635449 |doi= 10.1038/sj.emboj.7600526 | pmc=545815 }}
*{{cite journal | author=Bhattacharyya S, Luan J, Farooqi IS, ''et al.'' |title=Studies of the neuromedin U-2 receptor gene in human obesity: evidence for the existence of two ancestral forms of the receptor. |journal=J. Endocrinol. |volume=183 |issue= 1 |pages= 115-20 |year= 2004 |pmid= 15525579 |doi= 10.1677/joe.1.05830 }}
*{{cite journal   |vauthors=Fang L, Zhang M, Li C, etal |title=Chemical genetic analysis reveals the effects of NMU2R on the expression of peptide hormones. |journal=Neurosci. Lett. |volume=404 |issue= 1–2 |pages= 148–53 |year= 2006 |pmid= 16781063 |doi= 10.1016/j.neulet.2006.05.034 }}
*{{cite journal | author=Mori K, Miyazato M, Ida T, ''et al.'' |title=Identification of neuromedin S and its possible role in the mammalian circadian oscillator system. |journal=EMBO J. |volume=24 |issue= 2 |pages= 325-35 |year= 2005 |pmid= 15635449 |doi= 10.1038/sj.emboj.7600526 }}
*{{cite journal | author=Fang L, Zhang M, Li C, ''et al.'' |title=Chemical genetic analysis reveals the effects of NMU2R on the expression of peptide hormones. |journal=Neurosci. Lett. |volume=404 |issue= 1-2 |pages= 148-53 |year= 2006 |pmid= 16781063 |doi= 10.1016/j.neulet.2006.05.034 }}
}}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
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[[Category:G protein coupled receptors]]
[[Category:G protein coupled receptors]]
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{{transmembranereceptor-stub}}

Revision as of 15:52, 6 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Neuromedin-U receptor 2 is a protein that in humans is encoded by the NMUR2 gene.[1][2][3]


Ligands

Agonists

See also

References

  1. ↑ Tate CG, Grisshammer R (Jan 1997). "Heterologous expression of G-protein-coupled receptors". Trends Biotechnol. 14 (11): 426–30. doi:10.1016/0167-7799(96)10059-7. PMID 8940772.
  2. ↑ Howard AD, Wang R, Pong SS, Mellin TN, Strack A, Guan XM, Zeng Z, Williams DL Jr, Feighner SD, Nunes CN, Murphy B, Stair JN, Yu H, Jiang Q, Clements MK, Tan CP, McKee KK, Hreniuk DL, McDonald TP, Lynch KR, Evans JF, Austin CP, Caskey CT, Van der Ploeg LH, Liu Q (Jul 2000). "Identification of receptors for neuromedin U and its role in feeding". Nature. 406 (6791): 70–4. doi:10.1038/35017610. PMID 10894543.
  3. ↑ "Entrez Gene: NMUR2 neuromedin U receptor 2".
  4. ↑ Zheng X, Guo L, Wang D, Deng X (2014). "p-Synephrine: a novel agonist for neuromedin U2 receptor". Biol Pharm Bull. 37: 764–70. doi:10.1248/bpb.b13-00788. PMID 24598981. |access-date= requires |url= (help)

External links

Further reading


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