MAS1 oncogene: Difference between revisions

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{{infobox protein
 
{{protein
| Name = [[MAS1|MAS1 oncogene]]
| Name = [[MAS1|MAS1 oncogene]]
| caption =  
| caption =  
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| LocusSupplementaryData = -q27
| LocusSupplementaryData = -q27
}}
}}
{{protein
{{infobox protein
| Name = [[MAS1L|MAS1 oncogene-like]]
| Name = [[MAS1L|MAS1 oncogene-like]]
| caption =  
| caption =  
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}}
}}


The '''MAS1 oncogene''' is a [[G protein-coupled receptor]]<ref name="pmid3708691">{{cite journal | author = Young D, Waitches G, Birchmeier C, Fasano O, Wigler M | title = Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains | journal = Cell | volume = 45 | issue = 5 | pages = 711–9 | year = 1986 | pmid = 3708691 | doi = 10.1016/0092-8674(86)90785-3 | issn = }}</ref> which binds the [[angiotensin|angiotensin-II]] metabolite  angiotensin-(1-7).<ref name="pmid12829792">{{cite journal | author = Santos RA, Simoes e Silva AC, Maric C, Silva DM, Machado RP, de Buhr I, Heringer-Walther S, Pinheiro SV, Lopes MT, Bader M, Mendes EP, Lemos VS, Campagnole-Santos MJ, Schultheiss HP, Speth R, Walther T | title = Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 14 | pages = 8258–63 | year = 2003 | pmid = 12829792 | doi = 10.1073/pnas.1432869100 | issn = }}</ref><ref name="pmid17293687">{{cite journal | author = Santos RA, Ferreira AJ | title = Angiotensin-(1-7) and the renin-angiotensin system | journal = Curr. Opin. Nephrol. Hypertens. | volume = 16 | issue = 2 | pages = 122–8 | year = 2007 | pmid = 17293687 | doi = 10.1097/MNH.0b013e328031f362 | issn = }}</ref>  The MAS1 receptor when activated by binding angiotensin-(1-7) opposes many of the effects of angiotensin-II activated angiotensin receptor.  Hence MAS1 receptor [[agonist]]s have similar therapeutic effects as angiotensin-II receptor [[antagonist]]s including lowering blood pressure.<ref name="pmid17214600">{{cite journal | author = Santos RA, Ferreira AJ | title = Pharmacological effects of AVE 0991, a nonpeptide angiotensin-(1-7) receptor agonist | journal = Cardiovascular drug reviews | volume = 24 | issue = 3-4 | pages = 239–46 | year = 2006 | pmid = 17214600 | doi = 10.1111/j.1527-3466.2006.00239.x | issn = }}</ref>
The '''MAS1 oncogene''' is a [[G protein-coupled receptor]]<ref name="pmid3708691">{{cite journal |vauthors=Young D, Waitches G, Birchmeier C, Fasano O, Wigler M | title = Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains | journal = Cell | volume = 45 | issue = 5 | pages = 711–9 | year = 1986 | pmid = 3708691 | doi = 10.1016/0092-8674(86)90785-3 }}</ref> which binds the [[angiotensin|angiotensin-II]] metabolite  [[Angiotensin (1-7)]].<ref name="pmid12829792">{{cite journal |vauthors=Santos RA, Simoes e Silva AC, Maric C, Silva DM, Machado RP, de Buhr I, Heringer-Walther S, Pinheiro SV, Lopes MT, Bader M, Mendes EP, Lemos VS, Campagnole-Santos MJ, Schultheiss HP, Speth R, Walther T | title = Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 14 | pages = 8258–63 | year = 2003 | pmid = 12829792 | doi = 10.1073/pnas.1432869100 | pmc = 166216 }}</ref><ref name="pmid17293687">{{cite journal |vauthors=Santos RA, Ferreira AJ | title = Angiotensin-(1-7) and the renin-angiotensin system | journal = Curr. Opin. Nephrol. Hypertens. | volume = 16 | issue = 2 | pages = 122–8 | year = 2007 | pmid = 17293687 | doi = 10.1097/MNH.0b013e328031f362 }}</ref>  The MAS1 receptor when activated by binding angiotensin-(1-7) opposes many of the effects of angiotensin-II activated angiotensin receptor.  Hence MAS1 receptor [[agonist]]s have similar therapeutic effects as angiotensin-II receptor [[Receptor antagonist|antagonist]]s including lowering blood pressure.<ref name="pmid17214600">{{cite journal |vauthors=Santos RA, Ferreira AJ | title = Pharmacological effects of AVE 0991, a nonpeptide angiotensin-(1-7) receptor agonist | journal = Cardiovascular drug reviews | volume = 24 | issue = 3–4 | pages = 239–46 | year = 2006 | pmid = 17214600 | doi = 10.1111/j.1527-3466.2006.00239.x }}</ref>


== References ==
== References ==
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{{G protein-coupled receptors}}
{{G protein-coupled receptors}}


{{WH}}
 
{{WS}}
{{membrane-protein-stub}}

Latest revision as of 12:57, 12 November 2017

MAS1 oncogene
Identifiers
SymbolMAS1
Entrez4142
HUGO6899
OMIM165180
RefSeqNM_002377
UniProtP04201
Other data
LocusChr. 6 q24-q27
MAS1 oncogene-like
Identifiers
SymbolMAS1L
Entrez116511
HUGO13961
OMIM607235
RefSeqNM_052967
UniProtP35410
Other data
LocusChr. 6 p21

The MAS1 oncogene is a G protein-coupled receptor[1] which binds the angiotensin-II metabolite Angiotensin (1-7).[2][3] The MAS1 receptor when activated by binding angiotensin-(1-7) opposes many of the effects of angiotensin-II activated angiotensin receptor. Hence MAS1 receptor agonists have similar therapeutic effects as angiotensin-II receptor antagonists including lowering blood pressure.[4]

References

  1. ↑ Young D, Waitches G, Birchmeier C, Fasano O, Wigler M (1986). "Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains". Cell. 45 (5): 711–9. doi:10.1016/0092-8674(86)90785-3. PMID 3708691.
  2. ↑ Santos RA, Simoes e Silva AC, Maric C, Silva DM, Machado RP, de Buhr I, Heringer-Walther S, Pinheiro SV, Lopes MT, Bader M, Mendes EP, Lemos VS, Campagnole-Santos MJ, Schultheiss HP, Speth R, Walther T (2003). "Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas". Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8258–63. doi:10.1073/pnas.1432869100. PMC 166216. PMID 12829792.
  3. ↑ Santos RA, Ferreira AJ (2007). "Angiotensin-(1-7) and the renin-angiotensin system". Curr. Opin. Nephrol. Hypertens. 16 (2): 122–8. doi:10.1097/MNH.0b013e328031f362. PMID 17293687.
  4. ↑ Santos RA, Ferreira AJ (2006). "Pharmacological effects of AVE 0991, a nonpeptide angiotensin-(1-7) receptor agonist". Cardiovascular drug reviews. 24 (3–4): 239–46. doi:10.1111/j.1527-3466.2006.00239.x. PMID 17214600.

External links


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