5-HT1B receptor: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS (v470))
Line 1: Line 1:
{{Wrongtitle|title=5-HT<sub>1B</sub> receptor}}
{{DISPLAYTITLE:5-HT<sub>1B</sub> receptor}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''5-hydroxytryptamine receptor 1B''' also known as the '''5-HT<sub>1B</sub> receptor''' is a [[protein]] that in humans is encoded by the ''HTR1B'' [[gene]].<ref name="pmid1348246">{{cite journal | vauthors = Jin H, Oksenberg D, Ashkenazi A, Peroutka SJ, Duncan AM, Rozmahel R, Yang Y, Mengod G, Palacios JM, O'Dowd BF | title = Characterization of the human 5-hydroxytryptamine1B receptor | journal = The Journal of Biological Chemistry | volume = 267 | issue = 9 | pages = 5735–8 | date = Mar 1992 | pmid = 1348246 | doi = }}</ref><ref name="pmid11247661">{{cite journal | vauthors = Sanders AR, Cao Q, Taylor J, Levin TE, Badner JA, Cravchik A, Comeron JM, Naruya S, Del Rosario A, Salvi DA, Walczyk KA, Mowry BJ, Levinson DF, Crowe RR, Silverman JM, Gejman PV | title = Genetic diversity of the human serotonin receptor 1B (HTR1B) gene | journal = Genomics | volume = 72 | issue = 1 | pages = 1–14 | date = Feb 2001 | pmid = 11247661 | doi = 10.1006/geno.2000.6411 }}</ref> The 5-HT<sub>1B</sub> receptor is a [[5-HT receptor]] subtype.<ref name="entrez">{{cite web | title = Entrez Gene: HTR1B 5-hydroxytryptamine (serotonin) receptor 1B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3351| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = no
| update_citations = yes
}}<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = 5-hydroxytryptamine (serotonin) receptor 1B
  | HGNCid = 5287
| Symbol = HTR1B
| AltSymbols =; 5-HT1B; 5-HT1DB; HTR1D2; HTR1DB; S12
| OMIM = 182131
| ECnumber = 
| Homologene = 669
| MGIid = 96274
| GeneAtlas_image1 = PBB_GE_HTR1B_210799_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004993 |text = serotonin receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007187 |text = G-protein signaling, coupled to cyclic nucleotide second messenger}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3351
    | Hs_Ensembl = ENSG00000135312
    | Hs_RefseqProtein = NP_000854
    | Hs_RefseqmRNA = NM_000863
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 78228641
    | Hs_GenLoc_end = 78229900
    | Hs_Uniprot = P28222
    | Mm_EntrezGene = 15551
    | Mm_Ensembl = ENSMUSG00000049511
    | Mm_RefseqmRNA = NM_010482
    | Mm_RefseqProtein = NP_034612
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 81428110
    | Mm_GenLoc_end = 81429270
    | Mm_Uniprot = Q0VES5
  }}
}}
'''5-hydroxytryptamine (serotonin) receptor 1B''', also known as '''HTR1B''', is a human [[5-HT receptor]], but also denotes the [[gene]] encoding it.<ref name="entrez">{{cite web | title = Entrez Gene: HTR1B 5-hydroxytryptamine (serotonin) receptor 1B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3351| accessdate = }}</ref>


==Tissue distribution and function==
==Tissue distribution and function==
5-HT<sub>1B</sub> acts on the CNS, where it induces [[presynaptic inhibition]] and behavioural effects. It also has vascular effects, such as pulmonary [[vasoconstriction]].
5-HT<sub>1B</sub> receptors are widely distributed throughout the CNS with the highest concentrations found in the [[frontal cortex]], [[basal ganglia]], [[striatum]], and the [[hippocampus]].<ref>{{cite web | title = 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled| url = http://www.genecards.org/cgi-bin/carddisp.pl?gene=HTR1B| accessdate = 23 Feb 2013}}</ref>
The function of the 5-HT<sub>1B</sub> receptor differs depending upon its location.  In the frontal cortex, it is believed to act as a postsynaptic receptor inhibiting the release of [[dopamine]].  In the basal ganglia and the striatum, evidence suggests 5-HT signaling acts on an [[autoreceptor]], inhibiting the release of [[serotonin]]<ref>{{cite journal | vauthors = Pytliak M, Vargová V, Mechírová V, Felšöci M | title = Serotonin receptors - from molecular biology to clinical applications | journal = Physiological Research / Academia Scientiarum Bohemoslovaca | volume = 60 | issue = 1 | pages = 15–25 | year = 2011 | pmid = 20945968 }}</ref> and decreasing glutamatergic transmission by reducing miniature [[excitatory postsynaptic potential]] (mEPSP) frequency,<ref name="pmid23452061">{{cite journal | vauthors = Huang CC, Yeh CM, Wu MY, Hsu KS | title = A single in vivo cocaine administration impairs 5-HT(1B) receptor-induced long-term depression in the nucleus accumbens | journal = Journal of Neurochemistry | volume = 125 | issue = 6 | pages = 809–21 | date = Jun 2013 | pmid = 23452061 | doi = 10.1111/jnc.12227 | url = http://onlinelibrary.wiley.com/doi/10.1111/jnc.12227/abstract;jsessionid=7C95316EFE707E6FFD8FDC535264B19D.d03t04 }}</ref> respectively.  In the hippocampus, a recent study has demonstrated that activation of postsynaptic 5-HT<sub>1B</sub> [[heteroreceptor]]s produces a facilitation in excitatory synaptic transmission which is altered in depression.<ref name="pmid23502536">{{cite journal | vauthors = Cai X, Kallarackal AJ, Kvarta MD, Goluskin S, Gaylor K, Bailey AM, Lee HK, Huganir RL, Thompson SM | title = Local potentiation of excitatory synapses by serotonin and its alteration in rodent models of depression | journal = Nature Neuroscience | volume = 16 | issue = 4 | pages = 464–72 | date = Apr 2013 | pmid = 23502536 | doi = 10.1038/nn.3355 | url = http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.3355.html | pmc=3609911}}</ref>
When the expression of 5-HT<sub>1B</sub> in human cortex was traced throughout life, significant changes during adolescence were observed, in a way that is strongly correlated with the expression of 5-HT<sub>1E</sub>.<ref name="pmid24721318">{{cite journal | vauthors = Shoval G, Bar-Shira O, Zalsman G, John Mann J, Chechik G | title = Transitions in the transcriptome of the serotonergic and dopaminergic systems in the human brain during adolescence | journal = European Neuropsychopharmacology | volume = 24 | issue = 7 | pages = 1123–32 | date = Jul 2014 | pmid = 24721318 | doi = 10.1016/j.euroneuro.2014.02.009 }}</ref>


5-HT<sub>1B</sub> receptors are present in many parts of the human brain. The highest concentrations are found in the [[basal ganglia]], [[striatum]] and the [[frontal cortex]]. The function of the receptor differs between the areas: in the frontal lobes it is believed to act as an terminal receptor, inhibiting the release of [[dopamine]]. In the striatum and the basal ganglia, the 5-HT<sub>1B</sub> receptor is thought to act as an autoreceptor, inhibiting the release of [[serotonin]].
Outside the brain, 5-HT<sub>1B</sub> receptor activation also has vascular effects, such as pulmonary [[vasoconstriction]]. Furthermore, blocking 5-HT<sub>1B</sub> receptor signalling increases the number of [[osteoblast]]s, bone mass, and the bone formation rate.<ref name="pmid19041748">{{cite journal | vauthors = Yadav VK, Ryu JH, Suda N, Tanaka KF, Gingrich JA, Schütz G, Glorieux FH, Chiang CY, Zajac JD, Insogna KL, Mann JJ, Hen R, Ducy P, Karsenty G | title = Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum | journal = Cell | volume = 135 | issue = 5 | pages = 825–37 | date = Nov 2008 | pmid = 19041748 | pmc = 2614332 | doi = 10.1016/j.cell.2008.09.059 | url = http://www.medpagetoday.com/Endocrinology/Osteoporosis/11923 | laysource = medpagetoday.com }}</ref>


[[Knockout mice]] lacking the 5-HT<sub>1B</sub> gene has shown an increase of aggression and a higher preference for alcohol.<ref name="pmid11888546">{{cite journal | author = Hoyer D, Hannon JP, Martin GR | title = Molecular, pharmacological and functional diversity of 5-HT receptors | journal = Pharmacol. Biochem. Behav. | volume = 71 | issue = 4 | pages = 533-54 | year = 2002 | pmid = 11888546 | doi = 10.1016/S0091-3057(01)00746-8 | issn = }}</ref>
[[Knockout mice]] lacking the 5-HT<sub>1B</sub> gene have shown an increase in aggression and a higher preference for alcohol.<ref name="pmid11888546">{{cite journal | vauthors = Hoyer D, Hannon JP, Martin GR | title = Molecular, pharmacological and functional diversity of 5-HT receptors | journal = Pharmacology, Biochemistry, and Behavior | volume = 71 | issue = 4 | pages = 533–54 | date = Apr 2002 | pmid = 11888546 | doi = 10.1016/S0091-3057(01)00746-8 }}</ref>  Under basal conditions, knockout mice present with a "normal" phenotype and exhibit a sucrose preference (lack of sucrose preference is considered a measure of anhedonia). However, after undergoing chronic unpredictable stress treatment to induce a "depression-like" phenotype these animals do not benefit from administration of [[selective serotonin reuptake inhibitor]] (SSRIs).<ref name="pmid23502536"/>


==Ligands==
==Ligands==
{| class="wikitable"
|-
! [[Agonist]]s
! [[Receptor antagonist|Antagonist]]s
|-
|
* [[ergotamine]] (vasoconstrictor in migraine)
* [[sumatriptan]] (vasoconstrictor in migraine)
*''5-carboxamidotryptamine (5-CT)''
|
* [[methiothepin]] ([[antipsychotic]])
* [[yohimbine]] ([[aphrodisiac]])
* [[metergoline]]
|-
|}


==See also==
===Agonists===
* [[Ergotamine]] (vasoconstrictor in migraine)
* [[Oxymetazoline]]
* [[Sumatriptan]] (vasoconstrictor in migraine)
* [[Zolmitriptan]]
* [[5-Carboxamidotryptamine]]
* [[CGS-12066A]]
* CP-93,129 (peripherally acting)
* [[CP-94,253]]
* [[CP-122,288]] (mixed 5-HT<sub>1B/1D</sub> agonist)
* CP-135,807 (mixed 5-HT<sub>1B/1D</sub> agonist)
* RU-24969 (mixed 5-HT<sub>1A/1B</sub> agonist)
 
===Partial agonists===
* [[Vortioxetine]] ([[antidepressant]])
* [[Ziprasidone]] ([[antipsychotic]])
* [[Asenapine]] ([[antipsychotic]])
 
===Antagonists and inverse agonists===
* [[Methiothepin]] ([[antipsychotic]])
* [[Yohimbine]] ([[aphrodisiac]])
* [[Metergoline]]
* [[Aripiprazole]]
* [[Isamoltane]]
* [[AR-A000002]]<ref>{{cite journal | vauthors = Hudzik TJ, Yanek M, Porrey T, Evenden J, Paronis C, Mastrangelo M, Ryan C, Ross S, Stenfors C | title = Behavioral pharmacology of AR-A000002, a novel, selective 5-hydroxytryptamine(1B) antagonist | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 304 | issue = 3 | pages = 1072–84 | date = Mar 2003 | pmid = 12604684 | doi = 10.1124/jpet.102.045468 }}</ref>
* [[SB-216,641]]
* SB-224,289 (inverse agonist)<ref>{{cite journal | vauthors = Selkirk JV, Scott C, Ho M, Burton MJ, Watson J, Gaster LM, Collin L, Jones BJ, Middlemiss DN, Price GW | title = SB-224289--a novel selective (human) 5-HT1B receptor antagonist with negative intrinsic activity | journal = British Journal of Pharmacology | volume = 125 | issue = 1 | pages = 202–8 | date = Sep 1998 | pmid = 9776361 | pmc = 1565605 | doi = 10.1038/sj.bjp.0702059 }}</ref>
* [[SB-236,057]] (inverse agonist)<ref>{{cite journal | vauthors = Roberts C, Watson J, Price GW, Middlemiss DN | title = SB-236057-A: a selective 5-HT1B receptor inverse agonist | journal = CNS Drug Reviews | volume = 7 | issue = 4 | pages = 433–44 | year = 2001 | pmid = 11830759 | doi = 10.1111/j.1527-3458.2001.tb00209.x }}</ref>
 
== Genetics ==
 
In humans the protein is coded by the gene ''HTR1B''.
 
A genetic variant in the promotor region, ''[[A-161T]]'', has been examined with respect to [[personality trait]]s and showed no major effect.<ref name="pmid14504413">{{cite journal | vauthors = Tsai SJ, Wang YC, Chen JY, Hong CJ | title = Allelic variants of the tryptophan hydroxylase (A218C) and serotonin 1B receptor (A-161T) and personality traits | journal = Neuropsychobiology | volume = 48 | issue = 2 | pages = 68–71 | year = 2003 | pmid = 14504413 | doi = 10.1159/000072879 }}</ref>
 
== See also ==
* [[5-HT1 receptor|5-HT<sub>1</sub> receptor]]
* [[5-HT1 receptor|5-HT<sub>1</sub> receptor]]
* [[5-HT receptor]]
* [[5-HT receptor]]


==References==
== References ==
{{reflist|2}}
{{reflist|33em}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin|33em}}
{{PBB_Further_reading
* {{cite journal | vauthors = Olivier B, van Oorschot R | title = 5-HT1B receptors and aggression: a review | journal = European Journal of Pharmacology | volume = 526 | issue = 1–3 | pages = 207–17 | date = Dec 2005 | pmid = 16310769 | doi = 10.1016/j.ejphar.2005.09.066 }}
| citations =
* {{cite journal | vauthors = Hamblin MW, Metcalf MA, McGuffin RW, Karpells S | title = Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity | journal = Biochemical and Biophysical Research Communications | volume = 184 | issue = 2 | pages = 752–9 | date = Apr 1992 | pmid = 1315531 | doi = 10.1016/0006-291X(92)90654-4 }}
*{{cite journal | author=Olivier B, van Oorschot R |title=5-HT1B receptors and aggression: a review. |journal=Eur. J. Pharmacol. |volume=526 |issue= 1-3 |pages= 207-17 |year= 2006 |pmid= 16310769 |doi= 10.1016/j.ejphar.2005.09.066 }}
* {{cite journal | vauthors = Veldman SA, Bienkowski MJ | title = Cloning and pharmacological characterization of a novel human 5-hydroxytryptamine1D receptor subtype | journal = Molecular Pharmacology | volume = 42 | issue = 3 | pages = 439–44 | date = Sep 1992 | pmid = 1328844 | doi =  }}
*{{cite journal | author=Hamblin MW, Metcalf MA, McGuffin RW, Karpells S |title=Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity. |journal=Biochem. Biophys. Res. Commun. |volume=184 |issue= 2 |pages= 752-9 |year= 1992 |pmid= 1315531 |doi= }}
* {{cite journal | vauthors = Demchyshyn L, Sunahara RK, Miller K, Teitler M, Hoffman BJ, Kennedy JL, Seeman P, Van Tol HH, Niznik HB | title = A human serotonin 1D receptor variant (5HT1D beta) encoded by an intronless gene on chromosome 6 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 89 | issue = 12 | pages = 5522–6 | date = Jun 1992 | pmid = 1351684 | pmc = 49324 | doi = 10.1073/pnas.89.12.5522 }}
*{{cite journal | author=Veldman SA, Bienkowski MJ |title=Cloning and pharmacological characterization of a novel human 5-hydroxytryptamine1D receptor subtype. |journal=Mol. Pharmacol. |volume=42 |issue= 3 |pages= 439-44 |year= 1992 |pmid= 1328844 |doi=  }}
* {{cite journal | vauthors = Levy FO, Gudermann T, Perez-Reyes E, Birnbaumer M, Kaumann AJ, Birnbaumer L | title = Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype | journal = The Journal of Biological Chemistry | volume = 267 | issue = 11 | pages = 7553–62 | date = Apr 1992 | pmid = 1559993 | doi =  }}
*{{cite journal | author=Jin H, Oksenberg D, Ashkenazi A, ''et al.'' |title=Characterization of the human 5-hydroxytryptamine1B receptor. |journal=J. Biol. Chem. |volume=267 |issue= 9 |pages= 5735-8 |year= 1992 |pmid= 1348246 |doi= }}
* {{cite journal | vauthors = Weinshank RL, Zgombick JM, Macchi MJ, Branchek TA, Hartig PR | title = Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 89 | issue = 8 | pages = 3630–4 | date = Apr 1992 | pmid = 1565658 | pmc = 48922 | doi = 10.1073/pnas.89.8.3630 }}
*{{cite journal | author=Demchyshyn L, Sunahara RK, Miller K, ''et al.'' |title=A human serotonin 1D receptor variant (5HT1D beta) encoded by an intronless gene on chromosome 6. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 12 |pages= 5522-6 |year= 1992 |pmid= 1351684 |doi=  }}
* {{cite journal | vauthors = Mochizuki D, Yuyama Y, Tsujita R, Komaki H, Sagai H | title = Cloning and expression of the human 5-HT1B-type receptor gene | journal = Biochemical and Biophysical Research Communications | volume = 185 | issue = 2 | pages = 517–23 | date = Jun 1992 | pmid = 1610347 | doi = 10.1016/0006-291X(92)91655-A }}
*{{cite journal | author=Levy FO, Gudermann T, Perez-Reyes E, ''et al.'' |title=Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype. |journal=J. Biol. Chem. |volume=267 |issue= 11 |pages= 7553-62 |year= 1992 |pmid= 1559993 |doi= }}
* {{cite journal | vauthors = Nöthen MM, Erdmann J, Shimron-Abarbanell D, Propping P | title = Identification of genetic variation in the human serotonin 1D beta receptor gene | journal = Biochemical and Biophysical Research Communications | volume = 205 | issue = 2 | pages = 1194–200 | date = Dec 1994 | pmid = 7802650 | doi = 10.1006/bbrc.1994.2792 }}
*{{cite journal | author=Weinshank RL, Zgombick JM, Macchi MJ, ''et al.'' |title=Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 8 |pages= 3630-4 |year= 1992 |pmid= 1565658 |doi= }}
* {{cite journal | vauthors = Ng GY, George SR, Zastawny RL, Caron M, Bouvier M, Dennis M, O'Dowd BF | title = Human serotonin1B receptor expression in Sf9 cells: phosphorylation, palmitoylation, and adenylyl cyclase inhibition | journal = Biochemistry | volume = 32 | issue = 43 | pages = 11727–33 | date = Nov 1993 | pmid = 8218242 | doi = 10.1021/bi00094a032 }}
*{{cite journal | author=Mochizuki D, Yuyama Y, Tsujita R, ''et al.'' |title=Cloning and expression of the human 5-HT1B-type receptor gene. |journal=Biochem. Biophys. Res. Commun. |volume=185 |issue= 2 |pages= 517-23 |year= 1992 |pmid= 1610347 |doi= }}
* {{cite journal | vauthors = Bouchelet I, Cohen Z, Case B, Séguéla P, Hamel E | title = Differential expression of sumatriptan-sensitive 5-hydroxytryptamine receptors in human trigeminal ganglia and cerebral blood vessels | journal = Molecular Pharmacology | volume = 50 | issue = 2 | pages = 219–23 | date = Aug 1996 | pmid = 8700126 | doi =  }}
*{{cite journal | author=Nöthen MM, Erdmann J, Shimron-Abarbanell D, Propping P |title=Identification of genetic variation in the human serotonin 1D beta receptor gene. |journal=Biochem. Biophys. Res. Commun. |volume=205 |issue= 2 |pages= 1194-200 |year= 1995 |pmid= 7802650 |doi= }}
* {{cite journal | vauthors = Varnäs K, Hall H, Bonaventure P, Sedvall G | title = Autoradiographic mapping of 5-HT(1B) and 5-HT(1D) receptors in the post mortem human brain using [(3)H]GR 125743 | journal = Brain Research | volume = 915 | issue = 1 | pages = 47–57 | date = Oct 2001 | pmid = 11578619 | doi = 10.1016/S0006-8993(01)02823-2 }}
*{{cite journal | author=Ng GY, George SR, Zastawny RL, ''et al.'' |title=Human serotonin1B receptor expression in Sf9 cells: phosphorylation, palmitoylation, and adenylyl cyclase inhibition. |journal=Biochemistry |volume=32 |issue= 43 |pages= 11727-33 |year= 1993 |pmid= 8218242 |doi=  }}
* {{cite journal | vauthors = Salim K, Fenton T, Bacha J, Urien-Rodriguez H, Bonnert T, Skynner HA, Watts E, Kerby J, Heald A, Beer M, McAllister G, Guest PC | title = Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation | journal = The Journal of Biological Chemistry | volume = 277 | issue = 18 | pages = 15482–5 | date = May 2002 | pmid = 11854302 | doi = 10.1074/jbc.M201539200 }}
*{{cite journal | author=Bouchelet I, Cohen Z, Case B, ''et al.'' |title=Differential expression of sumatriptan-sensitive 5-hydroxytryptamine receptors in human trigeminal ganglia and cerebral blood vessels. |journal=Mol. Pharmacol. |volume=50 |issue= 2 |pages= 219-23 |year= 1996 |pmid= 8700126 |doi= }}
* {{cite journal | vauthors = Hasegawa Y, Higuchi S, Matsushita S, Miyaoka H | title = Association of a polymorphism of the serotonin 1B receptor gene and alcohol dependence with inactive aldehyde dehydrogenase-2 | journal = Journal of Neural Transmission | volume = 109 | issue = 4 | pages = 513–21 | date = Apr 2002 | pmid = 11956970 | doi = 10.1007/s007020200042 }}
*{{cite journal | author=Sanders AR, Cao Q, Taylor J, ''et al.'' |title=Genetic diversity of the human serotonin receptor 1B (HTR1B) gene. |journal=Genomics |volume=72 |issue= 1 |pages= 1-14 |year= 2001 |pmid= 11247661 |doi= 10.1006/geno.2000.6411 }}
* {{cite journal | vauthors = Hawi Z, Dring M, Kirley A, Foley D, Kent L, Craddock N, Asherson P, Curran S, Gould A, Richards S, Lawson D, Pay H, Turic D, Langley K, Owen M, O'Donovan M, Thapar A, Fitzgerald M, Gill M | title = Serotonergic system and attention deficit hyperactivity disorder (ADHD): a potential susceptibility locus at the 5-HT(1B) receptor gene in 273 nuclear families from a multi-centre sample | journal = Molecular Psychiatry | volume = 7 | issue = 7 | pages = 718–25 | year = 2003 | pmid = 12192616 | doi = 10.1038/sj.mp.4001048 }}
*{{cite journal | author=Varnäs K, Hall H, Bonaventure P, Sedvall G |title=Autoradiographic mapping of 5-HT(1B) and 5-HT(1D) receptors in the post mortem human brain using [(3)H]GR 125743. |journal=Brain Res. |volume=915 |issue= 1 |pages= 47-57 |year= 2001 |pmid= 11578619 |doi= }}
* {{cite journal | vauthors = Huang YY, Oquendo MA, Friedman JM, Greenhill LL, Brodsky B, Malone KM, Khait V, Mann JJ | title = Substance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism | journal = Neuropsychopharmacology | volume = 28 | issue = 1 | pages = 163–9 | date = Jan 2003 | pmid = 12496953 | doi = 10.1038/sj.npp.1300000 }}
*{{cite journal | author=Salim K, Fenton T, Bacha J, ''et al.'' |title=Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15482-5 |year= 2002 |pmid= 11854302 |doi= 10.1074/jbc.M201539200 }}
* {{cite journal | vauthors = Quist JF, Barr CL, Schachar R, Roberts W, Malone M, Tannock R, Basile VS, Beitchman J, Kennedy JL | title = The serotonin 5-HT1B receptor gene and attention deficit hyperactivity disorder | journal = Molecular Psychiatry | volume = 8 | issue = 1 | pages = 98–102 | date = Jan 2003 | pmid = 12556913 | doi = 10.1038/sj.mp.4001244 }}
*{{cite journal | author=Hasegawa Y, Higuchi S, Matsushita S, Miyaoka H |title=Association of a polymorphism of the serotonin 1B receptor gene and alcohol dependence with inactive aldehyde dehydrogenase-2. |journal=Journal of neural transmission (Vienna, Austria : 1996) |volume=109 |issue= 4 |pages= 513-21 |year= 2002 |pmid= 11956970 |doi= 10.1007/s007020200042 }}
* {{cite journal | vauthors = Sinha R, Cloninger CR, Parsian A | title = Linkage disequilibrium and haplotype analysis between serotonin receptor 1B gene variations and subtypes of alcoholism | journal = American Journal of Medical Genetics Part B | volume = 121B | issue = 1 | pages = 83–8 | date = Aug 2003 | pmid = 12898580 | doi = 10.1002/ajmg.b.20064 }}
*{{cite journal | author=Hawi Z, Dring M, Kirley A, ''et al.'' |title=Serotonergic system and attention deficit hyperactivity disorder (ADHD): a potential susceptibility locus at the 5-HT(1B) receptor gene in 273 nuclear families from a multi-centre sample. |journal=Mol. Psychiatry |volume=7 |issue= 7 |pages= 718-25 |year= 2003 |pmid= 12192616 |doi= 10.1038/sj.mp.4001048 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Huang YY, Oquendo MA, Friedman JM, ''et al.'' |title=Substance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism. |journal=Neuropsychopharmacology |volume=28 |issue= 1 |pages= 163-9 |year= 2003 |pmid= 12496953 |doi= 10.1038/sj.npp.1300000 }}
*{{cite journal  | author=Quist JF, Barr CL, Schachar R, ''et al.'' |title=The serotonin 5-HT1B receptor gene and attention deficit hyperactivity disorder. |journal=Mol. Psychiatry |volume=8 |issue= 1 |pages= 98-102 |year= 2003 |pmid= 12556913 |doi= 10.1038/sj.mp.4001244 }}
*{{cite journal  | author=Sinha R, Cloninger CR, Parsian A |title=Linkage disequilibrium and haplotype analysis between serotonin receptor 1B gene variations and subtypes of alcoholism. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=121 |issue= 1 |pages= 83-8 |year= 2003 |pmid= 12898580 |doi= 10.1002/ajmg.b.20064 }}
}}
{{refend}}
{{refend}}
== External links ==
* {{cite web | url = http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=2 | title = 5-HT<sub>1B</sub>  | accessdate = | date = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = }}
* {{UCSC gene info|HTR1B}}


{{NLM content}}
{{NLM content}}
{{membrane-protein-stub}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]
{{Serotonergics}}
 
{{DEFAULTSORT:5-Ht1b Receptor}}
[[Category:Serotonin receptors]]
[[Category:Biology of attention deficit hyperactivity disorder]]

Revision as of 01:04, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

5-hydroxytryptamine receptor 1B also known as the 5-HT1B receptor is a protein that in humans is encoded by the HTR1B gene.[1][2] The 5-HT1B receptor is a 5-HT receptor subtype.[3]

Tissue distribution and function

5-HT1B receptors are widely distributed throughout the CNS with the highest concentrations found in the frontal cortex, basal ganglia, striatum, and the hippocampus.[4] The function of the 5-HT1B receptor differs depending upon its location. In the frontal cortex, it is believed to act as a postsynaptic receptor inhibiting the release of dopamine. In the basal ganglia and the striatum, evidence suggests 5-HT signaling acts on an autoreceptor, inhibiting the release of serotonin[5] and decreasing glutamatergic transmission by reducing miniature excitatory postsynaptic potential (mEPSP) frequency,[6] respectively. In the hippocampus, a recent study has demonstrated that activation of postsynaptic 5-HT1B heteroreceptors produces a facilitation in excitatory synaptic transmission which is altered in depression.[7] When the expression of 5-HT1B in human cortex was traced throughout life, significant changes during adolescence were observed, in a way that is strongly correlated with the expression of 5-HT1E.[8]

Outside the brain, 5-HT1B receptor activation also has vascular effects, such as pulmonary vasoconstriction. Furthermore, blocking 5-HT1B receptor signalling increases the number of osteoblasts, bone mass, and the bone formation rate.[9]

Knockout mice lacking the 5-HT1B gene have shown an increase in aggression and a higher preference for alcohol.[10] Under basal conditions, knockout mice present with a "normal" phenotype and exhibit a sucrose preference (lack of sucrose preference is considered a measure of anhedonia). However, after undergoing chronic unpredictable stress treatment to induce a "depression-like" phenotype these animals do not benefit from administration of selective serotonin reuptake inhibitor (SSRIs).[7]

Ligands

Agonists

Partial agonists

Antagonists and inverse agonists

Genetics

In humans the protein is coded by the gene HTR1B.

A genetic variant in the promotor region, A-161T, has been examined with respect to personality traits and showed no major effect.[14]

See also

References

  1. ↑ Jin H, Oksenberg D, Ashkenazi A, Peroutka SJ, Duncan AM, Rozmahel R, Yang Y, Mengod G, Palacios JM, O'Dowd BF (Mar 1992). "Characterization of the human 5-hydroxytryptamine1B receptor". The Journal of Biological Chemistry. 267 (9): 5735–8. PMID 1348246.
  2. ↑ Sanders AR, Cao Q, Taylor J, Levin TE, Badner JA, Cravchik A, Comeron JM, Naruya S, Del Rosario A, Salvi DA, Walczyk KA, Mowry BJ, Levinson DF, Crowe RR, Silverman JM, Gejman PV (Feb 2001). "Genetic diversity of the human serotonin receptor 1B (HTR1B) gene". Genomics. 72 (1): 1–14. doi:10.1006/geno.2000.6411. PMID 11247661.
  3. ↑ "Entrez Gene: HTR1B 5-hydroxytryptamine (serotonin) receptor 1B".
  4. ↑ "5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled". Retrieved 23 Feb 2013.
  5. ↑ Pytliak M, Vargová V, Mechírová V, Felšöci M (2011). "Serotonin receptors - from molecular biology to clinical applications". Physiological Research / Academia Scientiarum Bohemoslovaca. 60 (1): 15–25. PMID 20945968.
  6. ↑ Huang CC, Yeh CM, Wu MY, Hsu KS (Jun 2013). "A single in vivo cocaine administration impairs 5-HT(1B) receptor-induced long-term depression in the nucleus accumbens". Journal of Neurochemistry. 125 (6): 809–21. doi:10.1111/jnc.12227. PMID 23452061.
  7. ↑ 7.0 7.1 Cai X, Kallarackal AJ, Kvarta MD, Goluskin S, Gaylor K, Bailey AM, Lee HK, Huganir RL, Thompson SM (Apr 2013). "Local potentiation of excitatory synapses by serotonin and its alteration in rodent models of depression". Nature Neuroscience. 16 (4): 464–72. doi:10.1038/nn.3355. PMC 3609911. PMID 23502536.
  8. ↑ Shoval G, Bar-Shira O, Zalsman G, John Mann J, Chechik G (Jul 2014). "Transitions in the transcriptome of the serotonergic and dopaminergic systems in the human brain during adolescence". European Neuropsychopharmacology. 24 (7): 1123–32. doi:10.1016/j.euroneuro.2014.02.009. PMID 24721318.
  9. ↑ Yadav VK, Ryu JH, Suda N, Tanaka KF, Gingrich JA, Schütz G, Glorieux FH, Chiang CY, Zajac JD, Insogna KL, Mann JJ, Hen R, Ducy P, Karsenty G (Nov 2008). "Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum". Cell. 135 (5): 825–37. doi:10.1016/j.cell.2008.09.059. PMC 2614332. PMID 19041748.
  10. ↑ Hoyer D, Hannon JP, Martin GR (Apr 2002). "Molecular, pharmacological and functional diversity of 5-HT receptors". Pharmacology, Biochemistry, and Behavior. 71 (4): 533–54. doi:10.1016/S0091-3057(01)00746-8. PMID 11888546.
  11. ↑ Hudzik TJ, Yanek M, Porrey T, Evenden J, Paronis C, Mastrangelo M, Ryan C, Ross S, Stenfors C (Mar 2003). "Behavioral pharmacology of AR-A000002, a novel, selective 5-hydroxytryptamine(1B) antagonist". The Journal of Pharmacology and Experimental Therapeutics. 304 (3): 1072–84. doi:10.1124/jpet.102.045468. PMID 12604684.
  12. ↑ Selkirk JV, Scott C, Ho M, Burton MJ, Watson J, Gaster LM, Collin L, Jones BJ, Middlemiss DN, Price GW (Sep 1998). "SB-224289--a novel selective (human) 5-HT1B receptor antagonist with negative intrinsic activity". British Journal of Pharmacology. 125 (1): 202–8. doi:10.1038/sj.bjp.0702059. PMC 1565605. PMID 9776361.
  13. ↑ Roberts C, Watson J, Price GW, Middlemiss DN (2001). "SB-236057-A: a selective 5-HT1B receptor inverse agonist". CNS Drug Reviews. 7 (4): 433–44. doi:10.1111/j.1527-3458.2001.tb00209.x. PMID 11830759.
  14. ↑ Tsai SJ, Wang YC, Chen JY, Hong CJ (2003). "Allelic variants of the tryptophan hydroxylase (A218C) and serotonin 1B receptor (A-161T) and personality traits". Neuropsychobiology. 48 (2): 68–71. doi:10.1159/000072879. PMID 14504413.

Further reading

  • Olivier B, van Oorschot R (Dec 2005). "5-HT1B receptors and aggression: a review". European Journal of Pharmacology. 526 (1–3): 207–17. doi:10.1016/j.ejphar.2005.09.066. PMID 16310769.
  • Hamblin MW, Metcalf MA, McGuffin RW, Karpells S (Apr 1992). "Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity". Biochemical and Biophysical Research Communications. 184 (2): 752–9. doi:10.1016/0006-291X(92)90654-4. PMID 1315531.
  • Veldman SA, Bienkowski MJ (Sep 1992). "Cloning and pharmacological characterization of a novel human 5-hydroxytryptamine1D receptor subtype". Molecular Pharmacology. 42 (3): 439–44. PMID 1328844.
  • Demchyshyn L, Sunahara RK, Miller K, Teitler M, Hoffman BJ, Kennedy JL, Seeman P, Van Tol HH, Niznik HB (Jun 1992). "A human serotonin 1D receptor variant (5HT1D beta) encoded by an intronless gene on chromosome 6". Proceedings of the National Academy of Sciences of the United States of America. 89 (12): 5522–6. doi:10.1073/pnas.89.12.5522. PMC 49324. PMID 1351684.
  • Levy FO, Gudermann T, Perez-Reyes E, Birnbaumer M, Kaumann AJ, Birnbaumer L (Apr 1992). "Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype". The Journal of Biological Chemistry. 267 (11): 7553–62. PMID 1559993.
  • Weinshank RL, Zgombick JM, Macchi MJ, Branchek TA, Hartig PR (Apr 1992). "Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta". Proceedings of the National Academy of Sciences of the United States of America. 89 (8): 3630–4. doi:10.1073/pnas.89.8.3630. PMC 48922. PMID 1565658.
  • Mochizuki D, Yuyama Y, Tsujita R, Komaki H, Sagai H (Jun 1992). "Cloning and expression of the human 5-HT1B-type receptor gene". Biochemical and Biophysical Research Communications. 185 (2): 517–23. doi:10.1016/0006-291X(92)91655-A. PMID 1610347.
  • Nöthen MM, Erdmann J, Shimron-Abarbanell D, Propping P (Dec 1994). "Identification of genetic variation in the human serotonin 1D beta receptor gene". Biochemical and Biophysical Research Communications. 205 (2): 1194–200. doi:10.1006/bbrc.1994.2792. PMID 7802650.
  • Ng GY, George SR, Zastawny RL, Caron M, Bouvier M, Dennis M, O'Dowd BF (Nov 1993). "Human serotonin1B receptor expression in Sf9 cells: phosphorylation, palmitoylation, and adenylyl cyclase inhibition". Biochemistry. 32 (43): 11727–33. doi:10.1021/bi00094a032. PMID 8218242.
  • Bouchelet I, Cohen Z, Case B, Séguéla P, Hamel E (Aug 1996). "Differential expression of sumatriptan-sensitive 5-hydroxytryptamine receptors in human trigeminal ganglia and cerebral blood vessels". Molecular Pharmacology. 50 (2): 219–23. PMID 8700126.
  • Varnäs K, Hall H, Bonaventure P, Sedvall G (Oct 2001). "Autoradiographic mapping of 5-HT(1B) and 5-HT(1D) receptors in the post mortem human brain using [(3)H]GR 125743". Brain Research. 915 (1): 47–57. doi:10.1016/S0006-8993(01)02823-2. PMID 11578619.
  • Salim K, Fenton T, Bacha J, Urien-Rodriguez H, Bonnert T, Skynner HA, Watts E, Kerby J, Heald A, Beer M, McAllister G, Guest PC (May 2002). "Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation". The Journal of Biological Chemistry. 277 (18): 15482–5. doi:10.1074/jbc.M201539200. PMID 11854302.
  • Hasegawa Y, Higuchi S, Matsushita S, Miyaoka H (Apr 2002). "Association of a polymorphism of the serotonin 1B receptor gene and alcohol dependence with inactive aldehyde dehydrogenase-2". Journal of Neural Transmission. 109 (4): 513–21. doi:10.1007/s007020200042. PMID 11956970.
  • Hawi Z, Dring M, Kirley A, Foley D, Kent L, Craddock N, Asherson P, Curran S, Gould A, Richards S, Lawson D, Pay H, Turic D, Langley K, Owen M, O'Donovan M, Thapar A, Fitzgerald M, Gill M (2003). "Serotonergic system and attention deficit hyperactivity disorder (ADHD): a potential susceptibility locus at the 5-HT(1B) receptor gene in 273 nuclear families from a multi-centre sample". Molecular Psychiatry. 7 (7): 718–25. doi:10.1038/sj.mp.4001048. PMID 12192616.
  • Huang YY, Oquendo MA, Friedman JM, Greenhill LL, Brodsky B, Malone KM, Khait V, Mann JJ (Jan 2003). "Substance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism". Neuropsychopharmacology. 28 (1): 163–9. doi:10.1038/sj.npp.1300000. PMID 12496953.
  • Quist JF, Barr CL, Schachar R, Roberts W, Malone M, Tannock R, Basile VS, Beitchman J, Kennedy JL (Jan 2003). "The serotonin 5-HT1B receptor gene and attention deficit hyperactivity disorder". Molecular Psychiatry. 8 (1): 98–102. doi:10.1038/sj.mp.4001244. PMID 12556913.
  • Sinha R, Cloninger CR, Parsian A (Aug 2003). "Linkage disequilibrium and haplotype analysis between serotonin receptor 1B gene variations and subtypes of alcoholism". American Journal of Medical Genetics Part B. 121B (1): 83–8. doi:10.1002/ajmg.b.20064. PMID 12898580.

External links

  • "5-HT1B". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
  • Human HTR1B genome location and HTR1B gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Retrieved from "https://www.wikidoc.org/index.php?title=5-HT1B_receptor&oldid=1420871"