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{{Infobox_gene}}
{{PBB_Controls
'''Probable G-protein coupled receptor 37''' is a [[protein]] that in humans is encoded by the ''GPR37'' [[gene]].<ref name="pmid9339362">{{cite journal | vauthors = Marazziti D, Golini E, Gallo A, Lombardi MS, Matteoni R, Tocchini-Valentini GP | title = Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library | journal = Genomics | volume = 45 | issue = 1 | pages = 68–77  | date = November 1997 | pmid = 9339362 | pmc =  | doi = 10.1006/geno.1997.4900 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2861| accessdate = }}</ref>
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = G protein-coupled receptor 37 (endothelin receptor type B-like)
| HGNCid = 4494
| Symbol = GPR37
| AltSymbols =; EDNRBL; PAELR; hET(B)R-LP
| OMIM = 602583
| ECnumber = 
| Homologene = 3875
| MGIid = 1313297
| GeneAtlas_image1 = PBB_GE_GPR37_209631_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_GPR37_214586_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2861
    | Hs_Ensembl = ENSG00000170775
    | Hs_RefseqProtein = NP_005293
    | Hs_RefseqmRNA = NM_005302
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 124173352
    | Hs_GenLoc_end = 124192917
    | Hs_Uniprot = O15354
    | Mm_EntrezGene = 14763
    | Mm_Ensembl = ENSMUSG00000039904
    | Mm_RefseqmRNA = NM_010338
    | Mm_RefseqProtein = NP_034468
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 25618118
    | Mm_GenLoc_end = 25640739
    | Mm_Uniprot = Q9QY42
  }}
}}
'''G protein-coupled receptor 37 (endothelin receptor type B-like)''', also known as '''GPR37''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2861| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
GPR37 has been shown to [[Protein-protein interaction|interact]] with [[HSPA1A]]<ref name=pmid12150907>{{cite journal | vauthors = Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R | title = CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity | journal = Mol. Cell | volume = 10 | issue = 1 | pages = 55–67  | date = July 2002 | pmid = 12150907 | doi = 10.1016/S1097-2765(02)00583-X }}</ref> and [[Parkin (ligase)]].<ref name=pmid12150907/><ref name=pmid11439185>{{cite journal | vauthors = Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R | title = An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin | journal = Cell | volume = 105 | issue = 7 | pages = 891–902 | date = June 2001 | pmid = 11439185 | doi = 10.1016/S0092-8674(01)00407-X }}</ref>
{{PBB_Summary
GPR37 is a receptor for [[prosaposin]]. It was previously thought to be a receptor for [[head activator]], a [[neuropeptide]] found in the [[hydra (genus)|hydra]], but early reports of head activator in mammals were never confirmed.<ref>{{cite journal |first1=Rebecca C.|last1=Meyer |first2=Michelle M.|last2=Giddens |first3=Stacy A.|last3=Schaefer |first4=Randy A.|last4=Hall |title=GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin |date=4 June 2013 |journal=Proceedings of the National Academy of Sciences |volume=110 |issue=23 |pages=9529–34 |doi=10.1073/pnas.1219004110 |url=http://www.pnas.org/content/110/23/9529.long |pmid=23690594 |pmc=3677493}}
| section_title =  
</ref>
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Zeng Z, Su K, Kyaw H, Li Y | title = A novel endothelin receptor type-B-like gene enriched in the brain | journal = Biochem. Biophys. Res. Commun. | volume = 233 | issue = 2 | pages = 559–67 | year = 1997 | pmid = 9144577 | doi = 10.1006/bbrc.1997.6408 }}
| citations =
* {{cite journal | vauthors = Donohue PJ, Shapira H, Mantey SA, Hampton LL, Jensen RT, Battey JF | title = A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system | journal = Brain Res. Mol. Brain Res. | volume = 54 | issue = 1 | pages = 152–60 | year = 1998 | pmid = 9526070 | doi = 10.1016/S0169-328X(97)00336-7 }}
*{{cite journal | author=Zeng Z, Su K, Kyaw H, Li Y |title=A novel endothelin receptor type-B-like gene enriched in the brain. |journal=Biochem. Biophys. Res. Commun. |volume=233 |issue= 2 |pages= 559-67 |year= 1997 |pmid= 9144577 |doi= 10.1006/bbrc.1997.6408 }}
* {{cite journal | vauthors = Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R | title = An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin | journal = Cell | volume = 105 | issue = 7 | pages = 891–902 | year = 2001 | pmid = 11439185 | doi = 10.1016/S0092-8674(01)00407-X }}
*{{cite journal | author=Marazziti D, Golini E, Gallo A, ''et al.'' |title=Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library. |journal=Genomics |volume=45 |issue= 1 |pages= 68-77 |year= 1997 |pmid= 9339362 |doi= 10.1006/geno.1997.4900 }}
* {{cite journal | vauthors = Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R | title = CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity | journal = Mol. Cell | volume = 10 | issue = 1 | pages = 55–67 | year = 2002 | pmid = 12150907 | doi = 10.1016/S1097-2765(02)00583-X }}
*{{cite journal  | author=Donohue PJ, Shapira H, Mantey SA, ''et al.'' |title=A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system. |journal=Brain Res. Mol. Brain Res. |volume=54 |issue= 1 |pages= 152-60 |year= 1998 |pmid= 9526070 |doi= }}
* {{cite journal | vauthors = Yang Y, Nishimura I, Imai Y, Takahashi R, Lu B | title = Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila | journal = Neuron | volume = 37 | issue = 6 | pages = 911–24 | year = 2003 | pmid = 12670421 | doi = 10.1016/S0896-6273(03)00143-0 }}
*{{cite journal | author=Imai Y, Soda M, Inoue H, ''et al.'' |title=An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin. |journal=Cell |volume=105 |issue= 7 |pages= 891-902 |year= 2001 |pmid= 11439185 |doi= }}
* {{cite journal | vauthors = Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R | title = A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death | journal = J. Biol. Chem. | volume = 278 | issue = 51 | pages = 51901–10 | year = 2003 | pmid = 14532270 | doi = 10.1074/jbc.M309655200 }}
*{{cite journal | author=Imai Y, Soda M, Hatakeyama S, ''et al.'' |title=CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity. |journal=Mol. Cell |volume=10 |issue= 1 |pages= 55-67 |year= 2002 |pmid= 12150907 |doi= }}
* {{cite journal | vauthors = Kubota K, Niinuma Y, Kaneko M, Okuma Y, Sugai M, Omura T, Uesugi M, Uehara T, Hosoi T, Nomura Y | title = Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress | journal = J. Neurochem. | volume = 97 | issue = 5 | pages = 1259–68 | year = 2006 | pmid = 16539653 | doi = 10.1111/j.1471-4159.2006.03782.x }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Omura T, Kaneko M, Okuma Y, Orba Y, Nagashima K, Takahashi R, Fujitani N, Matsumura S, Hata A, Kubota K, Murahashi K, Uehara T, Nomura Y | title = A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin | journal = J. Neurochem. | volume = 99 | issue = 6 | pages = 1456–69 | year = 2006 | pmid = 17059562 | doi = 10.1111/j.1471-4159.2006.04155.x }}
*{{cite journal | author=Yang Y, Nishimura I, Imai Y, ''et al.'' |title=Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila. |journal=Neuron |volume=37 |issue= 6 |pages= 911-24 |year= 2003 |pmid= 12670421 |doi=  }}
*{{cite journal  | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal  | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal | author=Imai Y, Soda M, Murakami T, ''et al.'' |title=A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. |journal=J. Biol. Chem. |volume=278 |issue= 51 |pages= 51901-10 |year= 2004 |pmid= 14532270 |doi= 10.1074/jbc.M309655200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Kubota K, Niinuma Y, Kaneko M, ''et al.'' |title=Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress. |journal=J. Neurochem. |volume=97 |issue= 5 |pages= 1259-68 |year= 2006 |pmid= 16539653 |doi= 10.1111/j.1471-4159.2006.03782.x }}
*{{cite journal | author=Omura T, Kaneko M, Okuma Y, ''et al.'' |title=A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin. |journal=J. Neurochem. |volume=99 |issue= 6 |pages= 1456-69 |year= 2007 |pmid= 17059562 |doi= 10.1111/j.1471-4159.2006.04155.x }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
{{DEFAULTSORT:Gpr37}}
[[Category:G protein coupled receptors]]
[[Category:G protein coupled receptors]]
{{WikiDoc Sources}}
 
 
{{transmembranereceptor-stub}}

Revision as of 00:56, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

n/a

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Probable G-protein coupled receptor 37 is a protein that in humans is encoded by the GPR37 gene.[1][2]

Interactions

GPR37 has been shown to interact with HSPA1A[3] and Parkin (ligase).[3][4] GPR37 is a receptor for prosaposin. It was previously thought to be a receptor for head activator, a neuropeptide found in the hydra, but early reports of head activator in mammals were never confirmed.[5]

References

  1. ↑ Marazziti D, Golini E, Gallo A, Lombardi MS, Matteoni R, Tocchini-Valentini GP (November 1997). "Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library". Genomics. 45 (1): 68–77. doi:10.1006/geno.1997.4900. PMID 9339362.
  2. ↑ "Entrez Gene: GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)".
  3. ↑ 3.0 3.1 Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R (July 2002). "CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity". Mol. Cell. 10 (1): 55–67. doi:10.1016/S1097-2765(02)00583-X. PMID 12150907.
  4. ↑ Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R (June 2001). "An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin". Cell. 105 (7): 891–902. doi:10.1016/S0092-8674(01)00407-X. PMID 11439185.
  5. ↑ Meyer, Rebecca C.; Giddens, Michelle M.; Schaefer, Stacy A.; Hall, Randy A. (4 June 2013). "GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin". Proceedings of the National Academy of Sciences. 110 (23): 9529–34. doi:10.1073/pnas.1219004110. PMC 3677493. PMID 23690594.

Further reading

  • Zeng Z, Su K, Kyaw H, Li Y (1997). "A novel endothelin receptor type-B-like gene enriched in the brain". Biochem. Biophys. Res. Commun. 233 (2): 559–67. doi:10.1006/bbrc.1997.6408. PMID 9144577.
  • Donohue PJ, Shapira H, Mantey SA, Hampton LL, Jensen RT, Battey JF (1998). "A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system". Brain Res. Mol. Brain Res. 54 (1): 152–60. doi:10.1016/S0169-328X(97)00336-7. PMID 9526070.
  • Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R (2001). "An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin". Cell. 105 (7): 891–902. doi:10.1016/S0092-8674(01)00407-X. PMID 11439185.
  • Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R (2002). "CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity". Mol. Cell. 10 (1): 55–67. doi:10.1016/S1097-2765(02)00583-X. PMID 12150907.
  • Yang Y, Nishimura I, Imai Y, Takahashi R, Lu B (2003). "Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila". Neuron. 37 (6): 911–24. doi:10.1016/S0896-6273(03)00143-0. PMID 12670421.
  • Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R (2003). "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death". J. Biol. Chem. 278 (51): 51901–10. doi:10.1074/jbc.M309655200. PMID 14532270.
  • Kubota K, Niinuma Y, Kaneko M, Okuma Y, Sugai M, Omura T, Uesugi M, Uehara T, Hosoi T, Nomura Y (2006). "Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress". J. Neurochem. 97 (5): 1259–68. doi:10.1111/j.1471-4159.2006.03782.x. PMID 16539653.
  • Omura T, Kaneko M, Okuma Y, Orba Y, Nagashima K, Takahashi R, Fujitani N, Matsumura S, Hata A, Kubota K, Murahashi K, Uehara T, Nomura Y (2006). "A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin". J. Neurochem. 99 (6): 1456–69. doi:10.1111/j.1471-4159.2006.04155.x. PMID 17059562.


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