GPR50: Difference between revisions

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{{Infobox_gene}}
'''G protein-coupled receptor 50''' is a [[protein]] which in humans is encoded by the '''''GPR50''''' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPR50 G protein-coupled receptor 50| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9248| accessdate = }}</ref><ref name="pmid8647286">{{cite journal |vauthors=Reppert SM, Weaver DR, Ebisawa T, Mahle CD, Kolakowski LF | title = Cloning of a melatonin-related receptor from human pituitary | journal = FEBS Letters | volume = 386 | issue = 2–3 | pages = 219–24 |date=May 1996 | pmid = 8647286 | doi = 10.1016/0014-5793(96)00437-1 | url =  }}</ref><ref name="pmid9933574">{{cite journal |vauthors=Gubitz AK, Reppert SM | title = Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50) | journal = Genomics | volume = 55 | issue = 2 | pages = 248–51 |date=January 1999 | pmid = 9933574 | doi = 10.1006/geno.1998.5661 | url =  }}</ref>


== Function ==
GPR50 is a member of the [[G protein-coupled receptor]] family of [[integral membrane protein]]s and is most closely related to the [[melatonin receptor]].<ref name="pmid8647286"/>  GPR50 is able to heterodimerize with both the [[melatonin receptor 1A|MT<sub>1</sub>]] and [[melatonin receptor 1B|MT<sub>2</sub>]] melatonin receptor subtypes.  While GPR50 has no effect on MT<sub>2</sub> function, GPR50 prevented MT<sub>1</sub> from both binding
[[melatonin]] and coupling to [[G protein]]s.<ref name="pmid16778767">{{cite journal |vauthors=Levoye A, Dam J, Ayoub MA, Guillaume JL, Couturier C, Delagrange P, Jockers R | title = The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization | journal = The EMBO Journal | volume = 25 | issue = 13 | pages = 3012–23 |date=July 2006 | pmid = 16778767 | pmc = 1500982 | doi = 10.1038/sj.emboj.7601193 | url =  }}</ref> GPR50 is the mammalian ortholog of melatonin receptor Mel1c described in non-mammalian vertebrates.
<ref>{{cite journal |vauthors=Dufourny L, Levasseur A, Migaud M, Callebaut I, Pontarotti P, Malpaux B, Monget P | title = GPR50 is the mammalian ortholog of Mel1c: Evidence of rapid evolution in mammals | journal = BMC Evolutionary Biology | volume = 8| pages = 105 | year = 2008 | pmid =  18400093| pmc =  2323367| doi = 10.1186/1471-2148-8-105 | url =  }}</ref>


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== Clinical significance ==
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Certain [[Polymorphism (biology)|polymorphism]]s of the ''GPR50'' gene in females are associated with increased risk of developing [[bipolar disorder|bipolar affective disorder]], [[major depressive disorder]], and  [[schizophrenia]].<ref name="pmid15452587">{{cite journal |vauthors=Thomson PA, Wray NR, Thomson AM, Dunbar DR, Grassie MA, Condie A, Walker MT, Smith DJ, Pulford DJ, Muir W, Blackwood DH, Porteous DJ | title = Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor | journal = Molecular Psychiatry | volume = 10 | issue = 5 | pages = 470–8 |date=May 2005 | pmid = 15452587 | doi = 10.1038/sj.mp.4001593 | url =  }}</ref> Other ''GPR50'' gene polymorphism are associated with higher fasting circulating [[triglyceride]] levels and lower circulating [[High-density lipoprotein]] levels.<ref name="pmid16436372">{{cite journal |vauthors=Bhattacharyya S, Luan J, Challis B, Keogh J, Montague C, Brennand J, Morten J, Lowenbeim S, Jenkins S, Farooqi IS, Wareham NJ, O'Rahilly S | title = Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels | journal = Journal of Lipid Research | volume = 47 | issue = 4 | pages = 761–6 |date=April 2006 | pmid = 16436372 | doi = 10.1194/jlr.M500338-JLR200 | url = }}</ref>
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==References==
{{GNF_Protein_box
{{reflist}}
| image = 
| image_source = 
| PDB =
| Name = G protein-coupled receptor 50
| HGNCid = 4506
| Symbol = GPR50
| AltSymbols =; H9; MGC125342
| OMIM = 300207
| ECnumber = 
| Homologene = 3113
| MGIid = 1333877
| GeneAtlas_image1 = PBB_GE_GPR50_208311_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0008502 |text = melatonin receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9248
    | Hs_Ensembl = ENSG00000102195
    | Hs_RefseqProtein = NP_004215
    | Hs_RefseqmRNA = NM_004224
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 150095783
    | Hs_GenLoc_end = 150100595
    | Hs_Uniprot = Q13585
    | Mm_EntrezGene = 14765
    | Mm_Ensembl = ENSMUSG00000056380
    | Mm_RefseqmRNA = XM_990925
    | Mm_RefseqProtein = XP_996019
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 67924323
    | Mm_GenLoc_end = 67928645
    | Mm_Uniprot = Q3V1S8
  }}
}}
'''G protein-coupled receptor 50''', also known as '''GPR50''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPR50 G protein-coupled receptor 50| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9248| accessdate = }}</ref>
 
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{{PBB_Summary
| section_title =
| summary_text =
}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Reppert SM, Weaver DR, Ebisawa T, ''et al.'' |title=Cloning of a melatonin-related receptor from human pituitary. |journal=FEBS Lett. |volume=386 |issue= 2-3 |pages= 219-24 |year= 1996 |pmid= 8647286 |doi=  }}
*{{cite journal  | author=Reppert SM |title=Cloning of a melatonin-related receptor from human pituitary |journal=FEBS Lett. |volume=386 |issue= 2–3 |pages= 219–24 |year= 1996 |pmid= 8647286 |doi=10.1016/0014-5793(96)00437-1  |name-list-format=vanc| author2=Weaver DR  | author3=Ebisawa T  | display-authors=3  | last4=Mahle  | first4=CD  | last5=Kolakowski Jr  | first5=LF }}
*{{cite journal  | author=Gubitz AK, Reppert SM |title=Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50). |journal=Genomics |volume=55 |issue= 2 |pages= 248-51 |year= 1999 |pmid= 9933574 |doi= 10.1006/geno.1998.5661 }}
*{{cite journal  |vauthors=Gubitz AK, Reppert SM |title=Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50) |journal=Genomics |volume=55 |issue= 2 |pages= 248–51 |year= 1999 |pmid= 9933574 |doi= 10.1006/geno.1998.5661 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Slominski A, Pisarchik A, Zbytek B, ''et al.'' |title=Functional activity of serotoninergic and melatoninergic systems expressed in the skin. |journal=J. Cell. Physiol. |volume=196 |issue= 1 |pages= 144-53 |year= 2003 |pmid= 12767050 |doi= 10.1002/jcp.10287 }}
*{{cite journal  | author=Slominski A |title=Functional activity of serotoninergic and melatoninergic systems expressed in the skin |journal=J. Cell. Physiol. |volume=196 |issue= 1 |pages= 144–53 |year= 2003 |pmid= 12767050 |doi= 10.1002/jcp.10287 |name-list-format=vanc| author2=Pisarchik A  | author3=Zbytek B  | display-authors=3  | last4=Tobin  | first4=Desmond J.  | last5=Kauser  | first5=S�bia  | last6=Wortsman  | first6=Jacobo }}
*{{cite journal  | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
*{{cite journal  | author=Suzuki Y |title=Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 | pmc=515316  |name-list-format=vanc| author2=Yamashita R  | author3=Shirota M  | display-authors=3  | last4=Sakakibara  | first4=Y  | last5=Chiba  | first5=J  | last6=Mizushima-Sugano  | first6=J  | last7=Nakai  | first7=K  | last8=Sugano  | first8=S }}
*{{cite journal  | author=Thomson PA, Wray NR, Thomson AM, ''et al.'' |title=Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor. |journal=Mol. Psychiatry |volume=10 |issue= 5 |pages= 470-8 |year= 2005 |pmid= 15452587 |doi= 10.1038/sj.mp.4001593 }}
*{{cite journal  | author=Thomson PA |title=Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor |journal=Mol. Psychiatry |volume=10 |issue= 5 |pages= 470–8 |year= 2005 |pmid= 15452587 |doi= 10.1038/sj.mp.4001593 |name-list-format=vanc| author2=Wray NR  | author3=Thomson AM  | display-authors=3  | last4=Dunbar  | first4=D R  | last5=Grassie  | first5=M A  | last6=Condie  | first6=A  | last7=Walker  | first7=M T  | last8=Smith  | first8=D J  | last9=Pulford  | first9=D J }}
*{{cite journal  | author=Bhattacharyya S, Luan J, Challis B, ''et al.'' |title=Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels. |journal=J. Lipid Res. |volume=47 |issue= 4 |pages= 761-6 |year= 2006 |pmid= 16436372 |doi= 10.1194/jlr.M500338-JLR200 }}
*{{cite journal  | author=Bhattacharyya S |title=Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels |journal=J. Lipid Res. |volume=47 |issue= 4 |pages= 761–6 |year= 2006 |pmid= 16436372 |doi= 10.1194/jlr.M500338-JLR200 |name-list-format=vanc| author2=Luan J  | author3=Challis B  | display-authors=3  | last4=Keogh  | first4=J  | last5=Montague  | first5=C  | last6=Brennand  | first6=J  | last7=Morten  | first7=J  | last8=Lowenbeim  | first8=S  | last9=Jenkins  | first9=S }}
*{{cite journal  | author=Levoye A, Dam J, Ayoub MA, ''et al.'' |title=The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization. |journal=EMBO J. |volume=25 |issue= 13 |pages= 3012-23 |year= 2006 |pmid= 16778767 |doi= 10.1038/sj.emboj.7601193 }}
*{{cite journal  | author=Levoye A |title=The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization |journal=EMBO J. |volume=25 |issue= 13 |pages= 3012–23 |year= 2006 |pmid= 16778767 |doi= 10.1038/sj.emboj.7601193 | pmc=1500982  |name-list-format=vanc| author2=Dam J  | author3=Ayoub MA  | display-authors=3  | last4=Guillaume  | first4=Jean-Luc  | last5=Couturier  | first5=Cyril  | last6=Delagrange  | first6=Philippe  | last7=Jockers  | first7=Ralf }}
}}
}}
{{refend}}
{{refend}}


{{NLM content}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
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[[Category:G protein coupled receptors]]
[[Category:G protein coupled receptors]]
{{WH}}
{{WS}}

Revision as of 02:24, 14 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

G protein-coupled receptor 50 is a protein which in humans is encoded by the GPR50 gene.[1][2][3]

Function

GPR50 is a member of the G protein-coupled receptor family of integral membrane proteins and is most closely related to the melatonin receptor.[2] GPR50 is able to heterodimerize with both the MT1 and MT2 melatonin receptor subtypes. While GPR50 has no effect on MT2 function, GPR50 prevented MT1 from both binding melatonin and coupling to G proteins.[4] GPR50 is the mammalian ortholog of melatonin receptor Mel1c described in non-mammalian vertebrates. [5]

Clinical significance

Certain polymorphisms of the GPR50 gene in females are associated with increased risk of developing bipolar affective disorder, major depressive disorder, and schizophrenia.[6] Other GPR50 gene polymorphism are associated with higher fasting circulating triglyceride levels and lower circulating High-density lipoprotein levels.[7]

References

  1. ↑ "Entrez Gene: GPR50 G protein-coupled receptor 50".
  2. ↑ 2.0 2.1 Reppert SM, Weaver DR, Ebisawa T, Mahle CD, Kolakowski LF (May 1996). "Cloning of a melatonin-related receptor from human pituitary". FEBS Letters. 386 (2–3): 219–24. doi:10.1016/0014-5793(96)00437-1. PMID 8647286.
  3. ↑ Gubitz AK, Reppert SM (January 1999). "Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50)". Genomics. 55 (2): 248–51. doi:10.1006/geno.1998.5661. PMID 9933574.
  4. ↑ Levoye A, Dam J, Ayoub MA, Guillaume JL, Couturier C, Delagrange P, Jockers R (July 2006). "The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization". The EMBO Journal. 25 (13): 3012–23. doi:10.1038/sj.emboj.7601193. PMC 1500982. PMID 16778767.
  5. ↑ Dufourny L, Levasseur A, Migaud M, Callebaut I, Pontarotti P, Malpaux B, Monget P (2008). "GPR50 is the mammalian ortholog of Mel1c: Evidence of rapid evolution in mammals". BMC Evolutionary Biology. 8: 105. doi:10.1186/1471-2148-8-105. PMC 2323367. PMID 18400093.
  6. ↑ Thomson PA, Wray NR, Thomson AM, Dunbar DR, Grassie MA, Condie A, Walker MT, Smith DJ, Pulford DJ, Muir W, Blackwood DH, Porteous DJ (May 2005). "Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor". Molecular Psychiatry. 10 (5): 470–8. doi:10.1038/sj.mp.4001593. PMID 15452587.
  7. ↑ Bhattacharyya S, Luan J, Challis B, Keogh J, Montague C, Brennand J, Morten J, Lowenbeim S, Jenkins S, Farooqi IS, Wareham NJ, O'Rahilly S (April 2006). "Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels". Journal of Lipid Research. 47 (4): 761–6. doi:10.1194/jlr.M500338-JLR200. PMID 16436372.

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=GPR50&oldid=1423360"