Additionally, GPR120 has been implicated to be involved in the ability to taste fats.[5] It is expressed in taste bud cells (specifically cell type II, which contain other G-protein coupled taste receptors), and its absence leads to reduced preference to two types of fatty acid (linoleic acid and oleic acid), as well as decreased neuronal response to oral fatty acids.[6]
References
↑ 1.01.1Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (Nov 2003). "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives". FEBS Lett. 554 (3): 381–8. doi:10.1016/S0014-5793(03)01196-7. PMID14623098.
↑Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, Yengo L, et al. (2012). "Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human". Nature. 483 (7389): 350–4. doi:10.1038/nature10798. PMID22343897.
Hirasawa A, Tsumaya K, Awaji T, Katsuma S, Adachi T, Yamada M, Sugimoto Y, Miyazaki S, Tsujimoto G (2005). "Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120". Nat. Med. 11 (1): 90–4. doi:10.1038/nm1168. PMID15619630.
Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID16341674.
