MRGPRX2: Difference between revisions
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'''Mas-related G-protein coupled receptor member X2''' is a [[protein]] that in humans is encoded by the ''MRGPRX2'' [[gene]].<ref name="pmid11551509">{{cite journal |vauthors=Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ | title = A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons | journal = Cell | volume = 106 | issue = 5 | pages = 619–632 |date=Sep 2001 | pmid = 11551509 | pmc = | doi =10.1016/S0092-8674(01)00483-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MRGPRX2 MAS-related GPR, member X2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=117194| accessdate = }}</ref> | '''Mas-related G-protein coupled receptor member X2''' is a [[protein]] that in humans is encoded by the ''MRGPRX2'' [[gene]].<ref name="pmid11551509">{{cite journal |vauthors=Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ | title = A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons | journal = Cell | volume = 106 | issue = 5 | pages = 619–632 |date=Sep 2001 | pmid = 11551509 | pmc = | doi =10.1016/S0092-8674(01)00483-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MRGPRX2 MAS-related GPR, member X2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=117194| accessdate = }}</ref> | ||
Agonists are gyrase inhibitors like ciprofloxacine and non-steroidal neuromuscular blocking agents like atracurium as well as vancomycin. Activation of MRGPRX2 leads to mast cell degranulation with subsequent pseudo-allergic reactions. | |||
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Latest revision as of 18:01, 24 September 2018
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Mas-related G-protein coupled receptor member X2 is a protein that in humans is encoded by the MRGPRX2 gene.[1][2] Agonists are gyrase inhibitors like ciprofloxacine and non-steroidal neuromuscular blocking agents like atracurium as well as vancomycin. Activation of MRGPRX2 leads to mast cell degranulation with subsequent pseudo-allergic reactions.
See also
References
- ↑ Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ (Sep 2001). "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons". Cell. 106 (5): 619–632. doi:10.1016/S0092-8674(01)00483-4. PMID 11551509.
- ↑ "Entrez Gene: MRGPRX2 MAS-related GPR, member X2".
Further reading
- Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Robas N, Mead E, Fidock M (2004). "MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion". J. Biol. Chem. 278 (45): 44400–44404. doi:10.1074/jbc.M302456200. PMID 12915402.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Yang S, Liu Y, Lin AA, et al. (2005). "Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception". Gene. 352: 30–35. doi:10.1016/j.gene.2005.03.001. PMID 15862286.
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