GPR116: Difference between revisions

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{{Infobox gene}}
{{PBB_Controls
'''Probable G-protein coupled receptor 116''' is a [[protein]] that in humans is encoded by the ''GPR116'' [[gene]].<ref>{{cite book|last=Stacey|first=edited by S Yona, M Stacey|title=Adhesion-GPCRs : structure to function|year=2010|publisher=Springer Science+Business Media|location=New York|isbn=978-1-4419-7912-4}}</ref><ref name="pmid12435584">{{cite journal | vauthors = Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB | title = Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions | journal = FEBS Letters | volume = 531 | issue = 3 | pages = 407–14 | date = Nov 2002 | pmid = 12435584 | pmc =  | doi = 10.1016/S0014-5793(02)03574-3 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GPR116 G protein-coupled receptor 116| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=221395| accessdate = }}</ref>  GPR116 has now been shown to play an essential role in the regulation of [[lung surfactant]] homeostasis.<ref>{{cite journal | vauthors = Yang MY, Hilton MB, Seaman S, Haines DC, Nagashima K, Burks CM, Tessarollo L, Ivanova PT, Brown HA, Umstead TM, Floros J, Chroneos ZC, St Croix B | title = Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116 | journal = Cell Reports | volume = 3 | issue = 5 | pages = 1457–64 | date = May 2013 | pmid = 23684610 | doi = 10.1016/j.celrep.2013.04.019 | pmc=3695742}}</ref><ref>{{cite journal | vauthors = Fukuzawa T, Ishida J, Kato A, Ichinose T, Ariestanti DM, Takahashi T, Ito K, Abe J, Suzuki T, Wakana S, Fukamizu A, Nakamura N, Hirose S | title = Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D | journal = PLOS ONE | volume = 8 | issue = 7 | pages = e69451 | year = 2013 | pmid = 23922714 | doi = 10.1371/journal.pone.0069451 | pmc=3726689}}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== References ==
{{GNF_Protein_box
{{reflist}}
| image = 
| image_source = 
| PDB =
| Name = G protein-coupled receptor 116
| HGNCid = 19030
| Symbol = GPR116
| AltSymbols =; DKFZp564O1923; FLJ90640; KIAA0758; KPG_001
| OMIM = 
| ECnumber = 
| Homologene = 9065
| MGIid = 2182928
| GeneAtlas_image1 = PBB_GE_GPR116_212950_at_tn.png
| GeneAtlas_image2 = PBB_GE_GPR116_212951_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 221395
    | Hs_Ensembl = ENSG00000069122
    | Hs_RefseqProtein = NP_056049
    | Hs_RefseqmRNA = NM_015234
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 46928298
    | Hs_GenLoc_end = 47030639
    | Hs_Uniprot = Q8IZF2
    | Mm_EntrezGene = 224792
    | Mm_Ensembl = ENSMUSG00000056492
    | Mm_RefseqmRNA = XM_001003162
    | Mm_RefseqProtein = XP_001003162
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 42891663
    | Mm_GenLoc_end = 42921412
    | Mm_Uniprot =
  }}
}}
'''G protein-coupled receptor 116''', also known as '''GPR116''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPR116 G protein-coupled receptor 116| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=221395| accessdate = }}</ref>


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== Further reading ==
{{PBB_Summary
| section_title =
| summary_text =
}}
 
==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA | title = The G protein-coupled receptor repertoires of human and mouse | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 8 | pages = 4903–8 | date = Apr 2003 | pmid = 12679517 | pmc = 153653 | doi = 10.1073/pnas.0230374100 }}
| citations =
* {{cite journal | vauthors = Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB | title = The human and mouse repertoire of the adhesion family of G-protein-coupled receptors | journal = Genomics | volume = 84 | issue = 1 | pages = 23–33 | date = Jul 2004 | pmid = 15203201 | doi = 10.1016/j.ygeno.2003.12.004 }}
*{{cite journal | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 5 |pages= 277-86 |year= 1999 |pmid= 9872452 |doi=  }}
* {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–44 | date = Oct 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}
*{{cite journal  | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 6 |pages= 355-64 |year= 1999 |pmid= 10048485 |doi=  }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal  | author=Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB |title=Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. |journal=FEBS Lett. |volume=531 |issue= 3 |pages= 407-14 |year= 2002 |pmid= 12435584 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Vassilatis DK, Hohmann JG, Zeng H, ''et al.'' |title=The G protein-coupled receptor repertoires of human and mouse. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 8 |pages= 4903-8 |year= 2003 |pmid= 12679517 |doi= 10.1073/pnas.0230374100 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Bjarnadóttir TK, Fredriksson R, Höglund PJ, ''et al.'' |title=The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. |journal=Genomics |volume=84 |issue= 1 |pages= 23-33 |year= 2005 |pmid= 15203201 |doi= 10.1016/j.ygeno.2003.12.004 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal  | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal  | author=Liu T, Qian WJ, Gritsenko MA, ''et al.'' |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070-80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]
 
{{WikiDoc Sources}}
[[Category:G protein-coupled receptors]]
{{transmembranereceptor-stub}}

Latest revision as of 18:00, 24 September 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Probable G-protein coupled receptor 116 is a protein that in humans is encoded by the GPR116 gene.[1][2][3] GPR116 has now been shown to play an essential role in the regulation of lung surfactant homeostasis.[4][5]

References

  1. ↑ Stacey, edited by S Yona, M Stacey (2010). Adhesion-GPCRs : structure to function. New York: Springer Science+Business Media. ISBN 978-1-4419-7912-4.
  2. ↑ Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584.
  3. ↑ "Entrez Gene: GPR116 G protein-coupled receptor 116".
  4. ↑ Yang MY, Hilton MB, Seaman S, Haines DC, Nagashima K, Burks CM, Tessarollo L, Ivanova PT, Brown HA, Umstead TM, Floros J, Chroneos ZC, St Croix B (May 2013). "Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116". Cell Reports. 3 (5): 1457–64. doi:10.1016/j.celrep.2013.04.019. PMC 3695742. PMID 23684610.
  5. ↑ Fukuzawa T, Ishida J, Kato A, Ichinose T, Ariestanti DM, Takahashi T, Ito K, Abe J, Suzuki T, Wakana S, Fukamizu A, Nakamura N, Hirose S (2013). "Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D". PLOS ONE. 8 (7): e69451. doi:10.1371/journal.pone.0069451. PMC 3726689. PMID 23922714.

Further reading

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