FZD6: Difference between revisions
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Revision as of 17:21, 4 September 2012
| Frizzled homolog 6 (Drosophila) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | FZD6 ; Hfz6 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 2617 | ||||||||||
| |||||||||||
| RNA expression pattern | |||||||||||
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| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Frizzled homolog 6 (Drosophila), also known as FZD6, is a human gene.[1]
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD6 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and 7 transmembrane domains. However, unlike many other Fz family members, FDZ6 does not contain a C-terminal PDZ domain-binding motif.[1]
See also
References
Further reading
- Wang Y, Macke JP, Abella BS; et al. (1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled". J. Biol. Chem. 271 (8): 4468–76. PMID 8626800.
- Finch PW, He X, Kelley MJ; et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. PMID 9192640.
- Tokuhara M, Hirai M, Atomi Y; et al. (1998). "Molecular cloning of human Frizzled-6". Biochem. Biophys. Res. Commun. 243 (2): 622–7. doi:10.1006/bbrc.1998.8143. PMID 9480858.
- Bafico A, Gazit A, Pramila T; et al. (1999). "Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling". J. Biol. Chem. 274 (23): 16180–7. PMID 10347172.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Golan T, Yaniv A, Bafico A; et al. (2004). "The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade". J. Biol. Chem. 279 (15): 14879–88. doi:10.1074/jbc.M306421200. PMID 14747478.
- Omoto S, Hayashi T, Kitahara K; et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
- Sirchia R, Luparello C (2007). "Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells". Biol. Chem. 388 (5): 457–65. doi:10.1515/BC.2007.059. PMID 17516841.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.