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EGF-like module-containing mucin-like hormone receptor-like 1 also known as F4/80 is a protein encoded by the ADGRE1gene.[1][2][3][4][5] EMR1 is a member of the adhesion GPCR family.[6][7]
Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[8]
EMR1 expression in human is restricted to eosinophils and is a specific marker for these cells.[9] The murine homolog of EMR1, F4/80, is a well-known and widely used marker of murine macrophage populations.[10] The N-terminal fragment (NTF) of EMR1 contains 4-6 Epidermal Growth Factor-like (EGF-like) domains in human and 4-7 EGF-like domains in the mouse.[11]
Utilizing F4/80 knockout mice, Lin et al. showed that F4/80 is not necessary for the development of tissue macrophages but is required for the induction of efferent CD8+ regulatory T cells needed for peripheral tolerance.[12]
Clinical significance
Legrand et al. demonstrated that EMR1 can serve as a therapeutic target for depletion of these cells in eosinophilic disorders by using afucosylated antibodies.[13]
↑Baud V, Chissoe SL, Viegas-Péquignot E, Diriong S, N'Guyen VC, Roe BA, Lipinski M (March 1995). "EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments". Genomics. 26 (2): 334–44. doi:10.1016/0888-7543(95)80218-B. PMID7601460.
↑McKnight AJ, Gordon S (March 1998). "The EGF-TM7 family: unusual structures at the leukocyte surface". Journal of Leukocyte Biology. 63 (3): 271–80. PMID9500513.
↑Leenen PJ, de Bruijn MF, Voerman JS, Campbell PA, van Ewijk W (September 1994). "Markers of mouse macrophage development detected by monoclonal antibodies". Journal of Immunological Methods. 174 (1–2): 5–19. doi:10.1016/0022-1759(94)90005-1. PMID8083537.
↑Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN1-4419-7912-3.
↑Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID23695165.
↑Hamann J, Koning N, Pouwels W, Ulfman LH, van Eijk M, Stacey M, Lin HH, Gordon S, Kwakkenbos MJ (October 2007). "EMR1, the human homolog of F4/80, is an eosinophil-specific receptor". European Journal of Immunology. 37 (10): 2797–802. doi:10.1002/eji.200737553. PMID17823986.
↑Austyn JM, Gordon S (October 1981). "F4/80, a monoclonal antibody directed specifically against the mouse macrophage". European Journal of Immunology. 11 (10): 805–15. doi:10.1002/eji.1830111013. PMID7308288.
↑Gordon S, Hamann J, Lin HH, Stacey M (September 2011). "F4/80 and the related adhesion-GPCRs". European Journal of Immunology. 41 (9): 2472–6. doi:10.1002/eji.201141715. PMID21952799.
