Metabotropic glutamate receptor 5

Metabotropic glutamate receptor 5
Identifiers
Symbols	GRM5 ; GPRC1E; MGLUR5; MGLUR5A; MGLUR5B; mGlu5
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37354
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE GRM5 207235 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Metabotropic glutamate receptor 5, also known as mGluR5 or GRM5, is a human gene. The amino acid L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7, and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of GRM8 have been described but their full-length nature has not been determined.

See also

• Metabotropic glutamate receptor

Further reading

• Minakami R, Katsuki F, Sugiyama H (1993). "A variant of metabotropic glutamate receptor subtype 5: an evolutionally conserved insertion with no termination codon". Biochem. Biophys. Res. Commun. 194 (2): 622–7. doi:10.1006/bbrc.1993.1866. PMID 7688218.CS1 maint: Multiple names: authors list (link)
• Minakami R, Katsuki F, Yamamoto T; et al. (1994). "Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5". Biochem. Biophys. Res. Commun. 199 (3): 1136–43. doi:10.1006/bbrc.1994.1349. PMID 7908515.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Daggett LP, Sacaan AI, Akong M; et al. (1996). "Molecular and functional characterization of recombinant human metabotropic glutamate receptor subtype 5". Neuropharmacology. 34 (8): 871–86. PMID 8532169.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brakeman PR, Lanahan AA, O'Brien R; et al. (1997). "Homer: a protein that selectively binds metabotropic glutamate receptors". Nature. 386 (6622): 284–8. doi:10.1038/386284a0. PMID 9069287.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Minakami R, Jinnai N, Sugiyama H (1997). "Phosphorylation and calmodulin binding of the metabotropic glutamate receptor subtype 5 (mGluR5) are antagonistic in vitro". J. Biol. Chem. 272 (32): 20291–8. PMID 9242710.CS1 maint: Multiple names: authors list (link)
• Snow BE, Hall RA, Krumins AM; et al. (1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". J. Biol. Chem. 273 (28): 17749–55. PMID 9651375.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xiao B, Tu JC, Petralia RS; et al. (1998). "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins". Neuron. 21 (4): 707–16. PMID 9808458.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Enz R (2002). "The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7". FEBS Lett. 514 (2–3): 184–8. PMID 11943148.
• Saugstad JA, Yang S, Pohl J; et al. (2002). "Interaction between metabotropic glutamate receptor 7 and alpha tubulin". J. Neurochem. 80 (6): 980–8. PMID 11953448.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nash MS, Schell MJ, Atkinson PJ; et al. (2002). "Determinants of metabotropic glutamate receptor-5-mediated Ca2+ and inositol 1,4,5-trisphosphate oscillation frequency. Receptor density versus agonist concentration". J. Biol. Chem. 277 (39): 35947–60. doi:10.1074/jbc.M205622200. PMID 12119301.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bates B, Xie Y, Taylor N; et al. (2003). "Characterization of mGluR5R, a novel, metabotropic glutamate receptor 5-related gene". Brain Res. Mol. Brain Res. 109 (1–2): 18–33. PMID 12531512.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Malherbe P, Kew JN, Richards JG; et al. (2003). "Identification and characterization of a novel splice variant of the metabotropic glutamate receptor 5 gene in human hippocampus and cerebellum". Brain Res. Mol. Brain Res. 109 (1–2): 168–78. PMID 12531526.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• O'Malley KL, Jong YJ, Gonchar Y; et al. (2003). "Activation of metabotropic glutamate receptor mGlu5 on nuclear membranes mediates intranuclear Ca2+ changes in heterologous cell types and neurons". J. Biol. Chem. 278 (30): 28210–9. doi:10.1074/jbc.M300792200. PMID 12736269.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Corti C, Clarkson RW, Crepaldi L; et al. (2003). "Gene structure of the human metabotropic glutamate receptor 5 and functional analysis of its multiple promoters in neuroblastoma and astroglioma cells". J. Biol. Chem. 278 (35): 33105–19. doi:10.1074/jbc.M212380200. PMID 12783878.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aronica E, Gorter JA, Ijlst-Keizers H; et al. (2003). "Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins". Eur. J. Neurosci. 17 (10): 2106–18. PMID 12786977.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Uchino M, Sakai N, Kashiwagi K; et al. (2004). "Isoform-specific phosphorylation of metabotropic glutamate receptor 5 by protein kinase C (PKC) blocks Ca2+ oscillation and oscillatory translocation of Ca2+-dependent PKC". J. Biol. Chem. 279 (3): 2254–61. doi:10.1074/jbc.M309894200. PMID 14561742.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Anneser JM, Ince PG, Shaw PJ, Borasio GD (2004). "Differential expression of mGluR5 in human lumbosacral motoneurons". Neuroreport. 15 (2): 271–3. PMID 15076751.CS1 maint: Multiple names: authors list (link)
• Pacheco R, Ciruela F, Casadó V; et al. (2004). "Group I metabotropic glutamate receptors mediate a dual role of glutamate in T cell activation". J. Biol. Chem. 279 (32): 33352–8. doi:10.1074/jbc.M401761200. PMID 15184389.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim CH, Braud S, Isaac JT, Roche KW (2005). "Protein kinase C phosphorylation of the metabotropic glutamate receptor mGluR5 on Serine 839 regulates Ca2+ oscillations". J. Biol. Chem. 280 (27): 25409–15. doi:10.1074/jbc.M502644200. PMID 15894802.CS1 maint: Multiple names: authors list (link)
• Cabello N, Remelli R, Canela L; et al. (2007). "Actin-binding protein alpha-actinin-1 interacts with the metabotropic glutamate receptor type 5b and modulates the cell surface expression and function of the receptor". J. Biol. Chem. 282 (16): 12143–53. doi:10.1074/jbc.M608880200. PMID 17311919.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.