P2RY6

Pyrimidinergic receptor P2Y, G-protein coupled, 6
Identifiers
Symbols	P2RY6 ; MGC15335; P2Y6
External IDs	Template:OMIM5 Template:MGI HomoloGene: 14289
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE P2RY6 208373 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Pyrimidinergic receptor P2Y, G-protein coupled, 6, also known as P2RY6, is a human gene.

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. Four transcript variants encoding the same isoform have been identified for this gene.

See also

• P2Y receptor

Further reading

• Communi D, Parmentier M, Boeynaems JM (1996). "Cloning, functional expression and tissue distribution of the human P2Y6 receptor". Biochem. Biophys. Res. Commun. 222 (2): 303–8. doi:10.1006/bbrc.1996.0739. PMID 8670200.CS1 maint: Multiple names: authors list (link)
• Maier R, Glatz A, Mosbacher J, Bilbe G (1997). "Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues". Biochem. Biophys. Res. Commun. 237 (2): 297–302. doi:10.1006/bbrc.1997.7135. PMID 9268704.CS1 maint: Multiple names: authors list (link)
• Somers GR, Hammet F, Woollatt E; et al. (1997). "Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family". Genomics. 44 (1): 127–30. doi:10.1006/geno.1997.4841. PMID 9286708.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maier R, Glatz A, Mosbacher J, Bilbe G (1997). "Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues". Biochem. Biophys. Res. Commun. 240 (2): 298–302. PMID 9412455.CS1 maint: Multiple names: authors list (link)
• Pidlaoan LV, Jin J, Sandhu AK; et al. (1998). "Colocalization of P2Y2 and P2Y6 receptor genes at human chromosome 11q13.3-14.1". Somat. Cell Mol. Genet. 23 (4): 291–6. PMID 9542531.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brinson AE, Harden TK (2001). "Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. SER-333 and SER-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor". J. Biol. Chem. 276 (15): 11939–48. doi:10.1074/jbc.M009909200. PMID 11114308.
• Moore DJ, Chambers JK, Wahlin JP; et al. (2001). "Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study". Biochim. Biophys. Acta. 1521 (1–3): 107–19. PMID 11690642.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hou M, Harden TK, Kuhn CM; et al. (2002). "UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors". Am. J. Physiol. Heart Circ. Physiol. 282 (2): H784–92. doi:10.1152/ajpheart.00997.2000. PMID 11788430.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Loomis WH, Namiki S, Ostrom RS; et al. (2003). "Hypertonic stress increases T cell interleukin-2 expression through a mechanism that involves ATP release, P2 receptor, and p38 MAPK activation". J. Biol. Chem. 278 (7): 4590–6. doi:10.1074/jbc.M207868200. PMID 12464620.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim SG, Soltysiak KA, Gao ZG; et al. (2003). "Tumor necrosis factor alpha-induced apoptosis in astrocytes is prevented by the activation of P2Y6, but not P2Y4 nucleotide receptors". Biochem. Pharmacol. 65 (6): 923–31. PMID 12623123.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schafer R, Sedehizade F, Welte T, Reiser G (2003). "ATP- and UTP-activated P2Y receptors differently regulate proliferation of human lung epithelial tumor cells". Am. J. Physiol. Lung Cell Mol. Physiol. 285 (2): L376–85. doi:10.1152/ajplung.00447.2002. PMID 12691958.CS1 maint: Multiple names: authors list (link)
• Lee H, Choi BH, Suh BC; et al. (2003). "Attenuation of signal flow from P2Y6 receptor by protein kinase C-alpha in SK-N-BE(2)C human neuroblastoma cells". J. Neurochem. 85 (4): 1043–53. PMID 12716436.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wan D, Gong Y, Qin W; et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMID 15498874.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cox MA, Gomes B, Palmer K; et al. (2005). "The pyrimidinergic P2Y6 receptor mediates a novel release of proinflammatory cytokines and chemokines in monocytic cells stimulated with UDP". Biochem. Biophys. Res. Commun. 330 (2): 467–73. doi:10.1016/j.bbrc.2005.03.004. PMID 15796906.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Khine AA, Del Sorbo L, Vaschetto R; et al. (2006). "Human neutrophil peptides induce interleukin-8 production through the P2Y6 signaling pathway". Blood. 107 (7): 2936–42. doi:10.1182/blood-2005-06-2314. PMID 16322472.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wihlborg AK, Balogh J, Wang L; et al. (2006). "Positive inotropic effects by uridine triphosphate (UTP) and uridine diphosphate (UDP) via P2Y2 and P2Y6 receptors on cardiomyocytes and release of UTP in man during myocardial infarction". Circ. Res. 98 (7): 970–6. doi:10.1161/01.RES.0000217402.73402.cd. PMID 16543499.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dulong S, Bernard K, Ehrenfeld J (2007). "Enhancement of P2Y6-induced Cl- secretion by IL-13 and modulation of SK4 channels activity in human bronchial cells". Cell. Physiol. Biochem. 20 (5): 483–94. doi:10.1159/000107532. PMID 17762175.CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.