TNFRSF12A
| Tumor necrosis factor receptor superfamily, member 12A | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | TNFRSF12A ; CD266; FN14; TWEAKR | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 8451 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE TNFRSF12A 218368 s at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Tumor necrosis factor receptor superfamily, member 12A, also known as TNFRSF12A, is a human gene.[1]
References
Further reading
- Campbell S, Michaelson J, Burkly L, Putterman C (2006). "The role of TWEAK/Fn14 in the pathogenesis of inflammation and systemic autoimmunity". Front. Biosci. 9: 2273–84. PMID 15353286.
- Meighan-Mantha RL, Hsu DK, Guo Y; et al. (2000). "The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration". J. Biol. Chem. 274 (46): 33166–76. PMID 10551889.
- Feng SL, Guo Y, Factor VM; et al. (2000). "The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas". Am. J. Pathol. 156 (4): 1253–61. PMID 10751351.
- Wiley SR, Cassiano L, Lofton T; et al. (2001). "A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis". Immunity. 15 (5): 837–46. PMID 11728344.
- Harada N, Nakayama M, Nakano H; et al. (2003). "Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells". Biochem. Biophys. Res. Commun. 299 (3): 488–93. PMID 12445828.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Nakayama M, Ishidoh K, Kojima Y; et al. (2003). "Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death". J. Immunol. 170 (1): 341–8. PMID 12496418.
- Tran NL, McDonough WS, Donohue PJ; et al. (2003). "The human Fn14 receptor gene is up-regulated in migrating glioma cells in vitro and overexpressed in advanced glial tumors". Am. J. Pathol. 162 (4): 1313–21. PMID 12651623.
- Tanabe K, Bonilla I, Winkles JA, Strittmatter SM (2003). "Fibroblast growth factor-inducible-14 is induced in axotomized neurons and promotes neurite outgrowth". J. Neurosci. 23 (29): 9675–86. PMID 14573547.
- Jin L, Nakao A, Nakayama M; et al. (2004). "Induction of RANTES by TWEAK/Fn14 interaction in human keratinocytes". J. Invest. Dermatol. 122 (5): 1175–9. doi:10.1111/j.0022-202X.2004.22419.x. PMID 15140220.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Tran NL, McDonough WS, Savitch BA; et al. (2005). "The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling system regulates glioma cell survival via NFkappaB pathway activation and BCL-XL/BCL-W expression". J. Biol. Chem. 280 (5): 3483–92. doi:10.1074/jbc.M409906200. PMID 15611130.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Chacón MR, Richart C, Gómez JM; et al. (2006). "Expression of TWEAK and its receptor Fn14 in human subcutaneous adipose tissue. Relationship with other inflammatory cytokines in obesity". Cytokine. 33 (3): 129–37. doi:10.1016/j.cyto.2005.12.005. PMID 16503147.
- Brown SA, Hanscom HN, Vu H; et al. (2006). "TWEAK binding to the Fn14 cysteine-rich domain depends on charged residues located in both the A1 and D2 modules". Biochem. J. 397 (2): 297–304. doi:10.1042/BJ20051362. PMID 16526941.
- Muñoz-García B, Martín-Ventura JL, Martínez E; et al. (2006). "Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques: modulation by atorvastatin". Stroke. 37 (8): 2044–53. doi:10.1161/01.STR.0000230648.00027.00. PMID 16809572.
- Tran NL, McDonough WS, Savitch BA; et al. (2007). "Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome". Cancer Res. 66 (19): 9535–42. doi:10.1158/0008-5472.CAN-06-0418. PMID 17018610.
- Girgenrath M, Weng S, Kostek CA; et al. (2007). "TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration". EMBO J. 25 (24): 5826–39. doi:10.1038/sj.emboj.7601441. PMID 17124496.
- Dogra C, Hall SL, Wedhas N; et al. (2007). "Fibroblast growth factor inducible 14 (Fn14) is required for the expression of myogenic regulatory factors and differentiation of myoblasts into myotubes. Evidence for TWEAK-independent functions of Fn14 during myogenesis". J. Biol. Chem. 282 (20): 15000–10. doi:10.1074/jbc.M608668200. PMID 17383968.
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