Melanocortin 4 receptor

Melanocortin 4 receptor
Identifiers
Symbols	MC4R ; MGC126851; MGC138197
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4320
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MC4R 221467 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Melanocortin 4 receptor, also known as MC4R, is a human gene.

See also

• Melanocortin receptor

Further reading

• Mountjoy KG, Mortrud MT, Low MJ; et al. (1995). "Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain". Mol. Endocrinol. 8 (10): 1298–308. PMID 7854347.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Magenis RE, Smith L, Nadeau JH; et al. (1994). "Mapping of the ACTH, MSH, and neural (MC3 and MC4) melanocortin receptors in the mouse and human". Mamm. Genome. 5 (8): 503–8. PMID 7949735.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gantz I, Miwa H, Konda Y; et al. (1993). "Molecular cloning, expression, and gene localization of a fourth melanocortin receptor". J. Biol. Chem. 268 (20): 15174–9. PMID 8392067.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Alvaro JD, Tatro JB, Quillan JM; et al. (1996). "Morphine down-regulates melanocortin-4 receptor expression in brain regions that mediate opiate addiction". Mol. Pharmacol. 50 (3): 583–91. PMID 8794897.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang YK, Ollmann MM, Wilson BD; et al. (1997). "Effects of recombinant agouti-signaling protein on melanocortin action". Mol. Endocrinol. 11 (3): 274–80. PMID 9058374.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chagnon YC, Chen WJ, Pérusse L; et al. (1998). "Linkage and association studies between the melanocortin receptors 4 and 5 genes and obesity-related phenotypes in the Québec Family Study". Mol. Med. 3 (10): 663–73. PMID 9392003.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sundaramurthy D, Campbell DA, Leek JP; et al. (1998). "Assignment of the melanocortin 4 receptor (MC4R) gene to human chromosome band 18q22 by in situ hybridisation and radiation hybrid mapping". Cytogenet. Cell Genet. 82 (1–2): 97–8. PMID 9763669.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yeo GS, Farooqi IS, Aminian S; et al. (1998). "A frameshift mutation in MC4R associated with dominantly inherited human obesity". Nat. Genet. 20 (2): 111–2. doi:10.1038/2404. PMID 9771698.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vaisse C, Clement K, Guy-Grand B, Froguel P (1998). "A frameshift mutation in human MC4R is associated with a dominant form of obesity". Nat. Genet. 20 (2): 113–4. doi:10.1038/2407. PMID 9771699.CS1 maint: Multiple names: authors list (link)
• Hinney A, Schmidt A, Nottebom K; et al. (1999). "Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans". J. Clin. Endocrinol. Metab. 84 (4): 1483–6. PMID 10199800.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang YK, Dickinson CJ, Zeng Q; et al. (1999). "Contribution of melanocortin receptor exoloops to Agouti-related protein binding". J. Biol. Chem. 274 (20): 14100–6. PMID 10318826.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ho G, MacKenzie RG (2000). "Functional characterization of mutations in melanocortin-4 receptor associated with human obesity". J. Biol. Chem. 274 (50): 35816–22. PMID 10585465.
• Yang YK, Fong TM, Dickinson CJ; et al. (2001). "Molecular determinants of ligand binding to the human melanocortin-4 receptor". Biochemistry. 39 (48): 14900–11. PMID 11101306.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mergen M, Mergen H, Ozata M; et al. (2001). "A novel melanocortin 4 receptor (MC4R) gene mutation associated with morbid obesity". J. Clin. Endocrinol. Metab. 86 (7): 3448. PMID 11443223.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McNulty JC, Thompson DA, Bolin KA; et al. (2002). "High-resolution NMR structure of the chemically-synthesized melanocortin receptor binding domain AGRP(87-132) of the agouti-related protein". Biochemistry. 40 (51): 15520–7. PMID 11747427.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brocke KS, Neu-Yilik G, Gehring NH; et al. (2002). "The human intronless melanocortin 4-receptor gene is NMD insensitive". Hum. Mol. Genet. 11 (3): 331–5. PMID 11823452.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang Y, Chen M, Lai Y; et al. (2002). "Molecular determinants of human melanocortin-4 receptor responsible for antagonist SHU9119 selective activity". J. Biol. Chem. 277 (23): 20328–35. doi:10.1074/jbc.M201343200. PMID 11912210.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hansen MJ, Morris MJ (2002). "Evidence for an interaction between neuropeptide Y and the melanocortin-4 receptor on feeding in the rat". Neuropharmacology. 42 (6): 792–7. PMID 12015205.
• Miraglia Del Giudice E, Cirillo G, Nigro V; et al. (2002). "Low frequency of melanocortin-4 receptor (MC4R) mutations in a Mediterranean population with early-onset obesity". Int. J. Obes. Relat. Metab. Disord. 26 (5): 647–51. doi:10.1038/sj.ijo.0801983. PMID 12032748.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim CS, Lee SH, Kim RY; et al. (2002). "Identification of domains directing specificity of coupling to G-proteins for the melanocortin MC3 and MC4 receptors". J. Biol. Chem. 277 (35): 31310–7. doi:10.1074/jbc.M112085200. PMID 12045190.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.