Galanin receptor 1

Galanin receptor 1
Identifiers
Symbols	GALR1 ; GALNR; GALNR1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 74396
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Galanin receptor 1, also known as GALR1, is a human gene.

The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart.

See also

• Galanin receptor

Further reading

• Habert-Ortoli E, Amiranoff B, Loquet I; et al. (1994). "Molecular cloning of a functional human galanin receptor". Proc. Natl. Acad. Sci. U.S.A. 91 (21): 9780–3. PMID 7524088.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Walli R, Schäfer H, Morys-Wortmann C; et al. (1995). "Identification and biochemical characterization of the human brain galanin receptor". J. Mol. Endocrinol. 13 (3): 347–56. PMID 7534460.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kask K, Berthold M, Kahl U; et al. (1996). "Delineation of the peptide binding site of the human galanin receptor". EMBO J. 15 (2): 236–44. PMID 8617199.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lorimer DD, Benya RV (1996). "Cloning and quantification of galanin-1 receptor expression by mucosal cells lining the human gastrointestinal tract". Biochem. Biophys. Res. Commun. 222 (2): 379–85. doi:10.1006/bbrc.1996.0752. PMID 8670213.
• Nicholl J, Kofler B, Sutherland GR; et al. (1997). "Assignment of the gene encoding human galanin receptor (GALNR) to 18q23 by in situ hybridization". Genomics. 30 (3): 629–30. doi:10.1006/geno.1995.1292. PMID 8825658.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sullivan KA, Shiao LL, Cascieri MA (1997). "Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors". Biochem. Biophys. Res. Commun. 233 (3): 823–8. doi:10.1006/bbrc.1997.6542. PMID 9168941.CS1 maint: Multiple names: authors list (link)
• Jacoby AS, Webb GC, Liu ML; et al. (1998). "Structural organization of the mouse and human GALR1 galanin receptor genes (Galnr and GALNR) and chromosomal localization of the mouse gene". Genomics. 45 (3): 496–508. doi:10.1006/geno.1997.4960. PMID 9367674.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lorimer DD, Matkowskj K, Benya RV (1998). "Cloning, chromosomal location, and transcriptional regulation of the human galanin-1 receptor gene (GALN1R)". Biochem. Biophys. Res. Commun. 241 (2): 558–64. doi:10.1006/bbrc.1997.7838. PMID 9425310.CS1 maint: Multiple names: authors list (link)
• Fitzgerald LW, Patterson JP, Conklin DS; et al. (1998). "Pharmacological and biochemical characterization of a recombinant human galanin GALR1 receptor: agonist character of chimeric galanin peptides". J. Pharmacol. Exp. Ther. 287 (2): 448–56. PMID 9808667.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Henson BS, Neubig RR, Jang I; et al. (2005). "Galanin receptor 1 has anti-proliferative effects in oral squamous cell carcinoma". J. Biol. Chem. 280 (24): 22564–71. doi:10.1074/jbc.M414589200. PMID 15767248.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schäuble N, Reichwald K, Grassl W; et al. (2005). "Human galanin (GAL) and galanin 1 receptor (GALR1) variations are not involved in fat intake and early onset obesity". J. Nutr. 135 (6): 1387–92. PMID 15930442.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Belfer I, Hipp H, Bollettino A; et al. (2007). "Alcoholism is associated with GALR3 but not two other galanin receptor genes". Genes Brain Behav. 6 (5): 473–81. doi:10.1111/j.1601-183X.2006.00275.x. PMID 17083333.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.