Prokineticin receptor 2
Prokineticin receptor 2 | |||||||||||
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Identifiers | |||||||||||
Symbols | PROKR2 ; KAL3; PKR2; GPR73L1; GPR73b; GPRg2; dJ680N4.3 | ||||||||||
External IDs | Template:OMIM5 Template:MGI HomoloGene: 16368 | ||||||||||
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RNA expression pattern | |||||||||||
File:PBB GE PROKR2 gnf1h10315 s at tn.png | |||||||||||
More reference expression data | |||||||||||
Orthologs | |||||||||||
Template:GNF Ortholog box | |||||||||||
Species | Human | Mouse | |||||||||
Entrez | n/a | n/a | |||||||||
Ensembl | n/a | n/a | |||||||||
UniProt | n/a | n/a | |||||||||
RefSeq (mRNA) | n/a | n/a | |||||||||
RefSeq (protein) | n/a | n/a | |||||||||
Location (UCSC) | n/a | n/a | |||||||||
PubMed search | n/a | n/a |
Prokineticin receptor 2, also known as PROKR2, is a human gene.[1]
Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins.[1]
See also
References
Further reading
- Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Lin DC, Bullock CM, Ehlert FJ; et al. (2002). "Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor". J. Biol. Chem. 277 (22): 19276–80. doi:10.1074/jbc.M202139200. PMID 11886876.
- Soga T, Matsumoto S, Oda T; et al. (2003). "Molecular cloning and characterization of prokineticin receptors". Biochim. Biophys. Acta. 1579 (2–3): 173–9. PMID 12427552.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Battersby S, Critchley HO, Morgan K; et al. (2004). "Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle". J. Clin. Endocrinol. Metab. 89 (5): 2463–9. PMID 15126578.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Pasquali D, Rossi V, Staibano S; et al. (2006). "The endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: Up-regulation of EG-VEGF/prokineticin 1 with malignancy". Endocrinology. 147 (9): 4245–51. doi:10.1210/en.2006-0614. PMID 16763065.
- Dodé C, Teixeira L, Levilliers J; et al. (2006). "Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2". PLoS Genet. 2 (10): e175. doi:10.1371/journal.pgen.0020175. PMID 17054399.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.