C5a anaphylatoxin chemotactic receptor C5a2 also known as C5L2, G protein-coupled receptor 77, is a protein that in humans is encoded by the C5AR2gene.[1][2]
The anaphylatoxins C3a, C4a, and C5a are cationic fragments generated during the complement cascade that participate in host defense. In the case of inappropriate complement activation, anaphylatoxins may be involved in autoimmunity and sepsis. C5a2 is coexpressed with the C5a receptor, (C5a1, C5aR, C5R1, CD88), on polymorphonuclear neutrophils and may modulate C5a1 activity.[2][3]
References
↑Lee DK, George SR, Cheng R, Nguyen T, Liu Y, Brown M, Lynch KR, O'Dowd BF (Feb 2001). "Identification of four novel human G protein-coupled receptors expressed in the brain". Brain Res Mol Brain Res. 86 (1–2): 13–22. doi:10.1016/S0169-328X(00)00242-4. PMID11165367.
↑Gerard NP, Lu B, Liu P, Craig S, Fujiwara Y, Okinaga S, Gerard C (December 2005). "An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2". J. Biol. Chem. 280 (48): 39677–80. doi:10.1074/jbc.C500287200. PMID16204243.
Further reading
Klos A, Wende E, Wareham KJ, Monk PN (2013). "International Union of Pharmacology. LXXXVII. Complement peptide C5a, C4a, and C3a receptors". Pharmacol. Rev. 65 (1): 500–43. doi:10.1124/pr.111.005223. PMID23383423.
Ohno M, Hirata T, Enomoto M, et al. (2000). "A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells". Mol. Immunol. 37 (8): 407–12. doi:10.1016/S0161-5890(00)00067-5. PMID11090875.
Cain SA, Monk PN (2002). "The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74)". J. Biol. Chem. 277 (9): 7165–9. doi:10.1074/jbc.C100714200. PMID11773063.
Kalant D, Cain SA, Maslowska M, et al. (2003). "The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein". J. Biol. Chem. 278 (13): 11123–9. doi:10.1074/jbc.M206169200. PMID12540846.
Otto M, Hawlisch H, Monk PN, et al. (2004). "C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism". J. Biol. Chem. 279 (1): 142–51. doi:10.1074/jbc.M310078200. PMID14570896.
Huber-Lang M, Sarma JV, Rittirsch D, et al. (2005). "Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans". J. Immunol. 174 (2): 1104–10. doi:10.4049/jimmunol.174.2.1104. PMID15634936.
Kalant D, MacLaren R, Cui W, et al. (2005). "C5L2 is a functional receptor for acylation-stimulating protein". J. Biol. Chem. 280 (25): 23936–44. doi:10.1074/jbc.M406921200. PMID15833747.
Johswich K, Martin M, Thalmann J, et al. (2007). "Ligand specificity of the anaphylatoxin C5L2 receptor and its regulation on myeloid and epithelial cell lines". J. Biol. Chem. 281 (51): 39088–95. doi:10.1074/jbc.M609734200. PMID17068344.
