Melatonin receptor 1B
| Melatonin receptor 1B | |||||||||||
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| Symbols | MTNR1B ; MT2; MEL-1B-R | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 4350 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE MTNR1B 208516 at tn.png | |||||||||||
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| Species | Human | Mouse | |||||||||
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| RefSeq (protein) | n/a | n/a | |||||||||
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Melatonin receptor 1B, also known as MTNR1B, is a human gene.[1]
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin.[1]
See also
References
Further reading
- Brzezinski A (1997). "Melatonin in humans". N. Engl. J. Med. 336 (3): 186–95. PMID 8988899.
- Reppert SM, Godson C, Mahle CD; et al. (1995). "Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor". Proc. Natl. Acad. Sci. U.S.A. 92 (19): 8734–8. PMID 7568007.
- Reppert SM, Weaver DR, Ebisawa T; et al. (1996). "Cloning of a melatonin-related receptor from human pituitary". FEBS Lett. 386 (2–3): 219–24. PMID 8647286.
- Niles LP, Wang J, Shen L; et al. (2000). "Melatonin receptor mRNA expression in human granulosa cells". Mol. Cell. Endocrinol. 156 (1–2): 107–10. PMID 10612428.
- Ebisawa T, Uchiyama M, Kajimura N; et al. (2000). "Genetic polymorphisms of human melatonin 1b receptor gene in circadian rhythm sleep disorders and controls". Neurosci. Lett. 280 (1): 29–32. PMID 10696804.
- Roy D, Angelini NL, Fujieda H; et al. (2001). "Cyclical regulation of GnRH gene expression in GT1-7 GnRH-secreting neurons by melatonin". Endocrinology. 142 (11): 4711–20. PMID 11606436.
- Ayoub MA, Couturier C, Lucas-Meunier E; et al. (2002). "Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer". J. Biol. Chem. 277 (24): 21522–8. doi:10.1074/jbc.M200729200. PMID 11940583.
- Yuan L, Collins AR, Dai J; et al. (2003). "MT(1) melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells". Mol. Cell. Endocrinol. 192 (1–2): 147–56. PMID 12088876.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Slominski A, Pisarchik A, Zbytek B; et al. (2003). "Functional activity of serotoninergic and melatoninergic systems expressed in the skin". J. Cell. Physiol. 196 (1): 144–53. doi:10.1002/jcp.10287. PMID 12767050.
- Ayoub MA, Levoye A, Delagrange P, Jockers R (2004). "Preferential formation of MT1/MT2 melatonin receptor heterodimers with distinct ligand interaction properties compared with MT2 homodimers". Mol. Pharmacol. 66 (2): 312–21. doi:10.1124/mol.104.000398. PMID 15266022.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Mazna P, Berka K, Jelinkova I; et al. (2005). "Ligand binding to the human MT2 melatonin receptor: the role of residues in transmembrane domains 3, 6, and 7". Biochem. Biophys. Res. Commun. 332 (3): 726–34. doi:10.1016/j.bbrc.2005.05.017. PMID 15913560.
- Ha E, Choe BK, Jung KH; et al. (2005). "Positive relationship between melatonin receptor type 1B polymorphism and rheumatoid factor in rheumatoid arthritis patients in the Korean population". J. Pineal Res. 39 (2): 201–5. doi:10.1111/j.1600-079X.2005.00237.x. PMID 16098099.
- Savaskan E, Jockers R, Ayoub M; et al. (2007). "The MT2 melatonin receptor subtype is present in human retina and decreases in Alzheimer's disease". Current Alzheimer research. 4 (1): 47–51. PMID 17316165.
- Suzuki S, Masui Y, Ohnuki M; et al. (2007). "Induction of metallothionein synthesis by cilostazol in mice and in human cultured neuronal cell lines". Biol. Pharm. Bull. 30 (4): 791–4. PMID 17409522.
- Qiu XS, Tang NL, Yeung HY; et al. (2007). "Melatonin receptor 1B (MTNR1B) gene polymorphism is associated with the occurrence of adolescent idiopathic scoliosis". Spine. 32 (16): 1748–53. doi:10.1097/BRS.0b013e3180b9f0ff. PMID 17632395.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.