Beta-1 adrenergic receptor

Adrenergic, beta-1-, receptor
Identifiers
Symbols	ADRB1 ; ADRB1R; B1AR; BETA1AR; RHR
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20171
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

The beta-1 adrenergic receptor (β₁ adrenoreceptor), also known as ADRB1, is an beta-adrenergic receptor, and also denotes the human gene encoding it.

Receptor

Actions

Actions of the β₁ receptor include:

• stimulate viscous, amylase-filled secretions from salivary glands
• Increase cardiac output
  • Increase heart rate in sinoatrial node (SA node) (chronotropic effect)
  • Increase atrial cardiac muscle contractility. (inotropic effect)
  • Increases contractility and automaticity of ventricular cardiac muscle.
  • Increases conduction and automaticity of atrioventricular node (AV node)

• Renin release from juxtaglomerular cells.
• Lipolysis in adipose tissue.
• Receptor also present in cerebral cortex.

Agonists

isoprenaline has higher affinity for β₁ than noradrenaline, which, in turn, binds with higher affinity than adrenaline. Selective agonists to the beta-1 receptor are:

• dobutamine (in cardiogenic shock)
• xamoterol (cardiac stimulant)

Antagonists

(Beta blockers) β1-selective ones are:

• Acebutolol (in hypertension, angina pectoris and arrhythmias)
• Atenolol (in hypertension, coronary heart disease, arrhythmias and myocardial infarction)
• Betaxolol (in hypertension and glaucoma)
• Bisoprolol (in hypertension, coronary heart disease, arrhythmias, myocardial infarction and ischemic heart diseases)
• Esmolol (in arrhythmias)
• Metoprolol (in hypertension, coronary heart disease, myocardial infarction and heart failure)
• Nebivolol (in hypertension)

Mechanism

G_s renders adenylate cyclase activated, resulting in increase of cAMP.

Gene

Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure.

See also

• Other adrenergic receptors
  • Alpha-1 adrenergic receptor
  • Alpha-2 adrenergic receptor
  • Beta-2 adrenergic receptor
  • Beta-3 adrenergic receptor

Further reading

• Frielle T, Kobilka B, Lefkowitz RJ, Caron MG (1989). "Human beta 1- and beta 2-adrenergic receptors: structurally and functionally related receptors derived from distinct genes". Trends Neurosci. 11 (7): 321–4. PMID 2465637.CS1 maint: Multiple names: authors list (link)
• Muszkat M (2007). "Interethnic differences in drug response: the contribution of genetic variability in beta adrenergic receptor and cytochrome P4502C9". Clin. Pharmacol. Ther. 82 (2): 215–8. doi:10.1038/sj.clpt.6100142. PMID 17329986.
• Yang-Feng TL, Xue FY, Zhong WW; et al. (1990). "Chromosomal organization of adrenergic receptor genes". Proc. Natl. Acad. Sci. U.S.A. 87 (4): 1516–20. PMID 2154750.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Forse RA, Leibel R, Gagner M (1989). "The effect of Escherichia coli endotoxin on the adrenergic control of lipolysis in the human adipocyte". J. Surg. Res. 46 (1): 41–8. PMID 2536864.CS1 maint: Multiple names: authors list (link)
• Frielle T, Collins S, Daniel KW; et al. (1987). "Cloning of the cDNA for the human beta 1-adrenergic receptor". Proc. Natl. Acad. Sci. U.S.A. 84 (22): 7920–4. PMID 2825170.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stiles GL, Strasser RH, Lavin TN; et al. (1983). "The cardiac beta-adrenergic receptor. Structural similarities of beta 1 and beta 2 receptor subtypes demonstrated by photoaffinity labeling". J. Biol. Chem. 258 (13): 8443–9. PMID 6305985.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hoehe MR, Otterud B, Hsieh WT; et al. (1995). "Genetic mapping of adrenergic receptor genes in humans". J. Mol. Med. 73 (6): 299–306. PMID 7583452.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Elies R, Ferrari I, Wallukat G; et al. (1996). "Structural and functional analysis of the B cell epitopes recognized by anti-receptor autoantibodies in patients with Chagas' disease". J. Immunol. 157 (9): 4203–11. PMID 8892658.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Oldenhof J, Vickery R, Anafi M; et al. (1998). "SH3 binding domains in the dopamine D4 receptor". Biochemistry. 37 (45): 15726–36. doi:10.1021/bi981634+. PMID 9843378.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mason DA, Moore JD, Green SA, Liggett SB (1999). "A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor". J. Biol. Chem. 274 (18): 12670–4. PMID 10212248.CS1 maint: Multiple names: authors list (link)
• Moore JD, Mason DA, Green SA; et al. (1999). "Racial differences in the frequencies of cardiac beta(1)-adrenergic receptor polymorphisms: analysis of c145A>G and c1165G>C". Hum. Mutat. 14 (3): 271. doi:10.1002/(SICI)1098-1004(1999)14:3<271::AID-HUMU14>3.0.CO;2-Q. PMID 10477438.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tang Y, Hu LA, Miller WE; et al. (1999). "Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor". Proc. Natl. Acad. Sci. U.S.A. 96 (22): 12559–64. PMID 10535961.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Podlowski S, Wenzel K, Luther HP; et al. (2000). "Beta1-adrenoceptor gene variations: a role in idiopathic dilated cardiomyopathy?". J. Mol. Med. 78 (2): 87–93. PMID 10794544.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shiina T, Kawasaki A, Nagao T, Kurose H (2000). "Interaction with beta-arrestin determines the difference in internalization behavor between beta1- and beta2-adrenergic receptors". J. Biol. Chem. 275 (37): 29082–90. doi:10.1074/jbc.M909757199. PMID 10862778.CS1 maint: Multiple names: authors list (link)
• Hu LA, Tang Y, Miller WE; et al. (2001). "beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors". J. Biol. Chem. 275 (49): 38659–66. doi:10.1074/jbc.M005938200. PMID 10995758.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Börjesson M, Magnusson Y, Hjalmarson A, Andersson B (2001). "A novel polymorphism in the gene coding for the beta(1)-adrenergic receptor associated with survival in patients with heart failure". Eur. Heart J. 21 (22): 1853–8. doi:10.1053/euhj.1999.1994. PMID 11052857.CS1 maint: Multiple names: authors list (link)
• Xu J, Paquet M, Lau AG; et al. (2001). "beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95". J. Biol. Chem. 276 (44): 41310–7. doi:10.1074/jbc.M107480200. PMID 11526121.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hu LA, Chen W, Premont RT; et al. (2002). "G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95". J. Biol. Chem. 277 (2): 1607–13. doi:10.1074/jbc.M107297200. PMID 11700307.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ranade K, Jorgenson E, Sheu WH; et al. (2002). "A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate". Am. J. Hum. Genet. 70 (4): 935–42. PMID 11854867.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)