Alpha-1B adrenergic receptor

Adrenergic, alpha-1B-, receptor
Identifiers
Symbols	ADRA1B ; ADRA1; ALPHA1BAR
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55477
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

The alpha-1B adrenergic receptor (α_1B adrenoreceptor), also known as ADRA1B, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.

Receptor

There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.

Gene

This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region.

See also

• Adrenergic receptor

Further reading

• Ramarao CS, Denker JM, Perez DM; et al. (1992). "Genomic organization and expression of the human alpha 1B-adrenergic receptor". J. Biol. Chem. 267 (30): 21936–45. PMID 1328250.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Allen LF, Lefkowitz RJ, Caron MG, Cotecchia S (1992). "G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity". Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11354–8. PMID 1662393.CS1 maint: Multiple names: authors list (link)
• Lomasney JW, Cotecchia S, Lorenz W; et al. (1991). "Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5". J. Biol. Chem. 266 (10): 6365–9. PMID 1706716.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang-Feng TL, Xue FY, Zhong WW; et al. (1990). "Chromosomal organization of adrenergic receptor genes". Proc. Natl. Acad. Sci. U.S.A. 87 (4): 1516–20. PMID 2154750.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schwinn DA, Johnston GI, Page SO; et al. (1995). "Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues". J. Pharmacol. Exp. Ther. 272 (1): 134–42. PMID 7815325.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Weinberg DH, Trivedi P, Tan CP; et al. (1994). "Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c". Biochem. Biophys. Res. Commun. 201 (3): 1296–304. PMID 8024574.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Forray C, Bard JA, Wetzel JM; et al. (1994). "The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype". Mol. Pharmacol. 45 (4): 703–8. PMID 8183249.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Diviani D, Lattion AL, Larbi N; et al. (1996). "Effect of different G protein-coupled receptor kinases on phosphorylation and desensitization of the alpha1B-adrenergic receptor". J. Biol. Chem. 271 (9): 5049–58. PMID 8617782.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Diviani D, Lattion AL, Cotecchia S (1997). "Characterization of the phosphorylation sites involved in G protein-coupled receptor kinase- and protein kinase C-mediated desensitization of the alpha1B-adrenergic receptor". J. Biol. Chem. 272 (45): 28712–9. PMID 9353340.CS1 maint: Multiple names: authors list (link)
• Qian A, Wang W, Sanborn BM (1998). "Evidence for the involvement of several intracellular domains in the coupling of oxytocin receptor to G alpha(q/11)". Cell. Signal. 10 (2): 101–5. PMID 9481484.CS1 maint: Multiple names: authors list (link)
• Sasaguri T, Teruya H, Ishida A; et al. (2000). "Linkage between alpha(1) adrenergic receptor and the Jak/STAT signaling pathway in vascular smooth muscle cells". Biochem. Biophys. Res. Commun. 268 (1): 25–30. doi:10.1006/bbrc.1999.2066. PMID 10652206.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Minneman KP, Lee D, Zhong H; et al. (2000). "Transcriptional responses to growth factor and G protein-coupled receptors in PC12 cells: comparison of alpha(1)-adrenergic receptor subtypes". J. Neurochem. 74 (6): 2392–400. PMID 10820200.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shibata K, Katsuma S, Koshimizu T; et al. (2003). "alpha 1-Adrenergic receptor subtypes differentially control the cell cycle of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1". J. Biol. Chem. 278 (1): 672–8. doi:10.1074/jbc.M201375200. PMID 12409310.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Diviani D, Lattion AL, Abuin L; et al. (2003). "The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis". J. Biol. Chem. 278 (21): 19331–40. doi:10.1074/jbc.M302110200. PMID 12644451.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gonzalez-Cabrera PJ, Gaivin RJ, Yun J; et al. (2003). "Genetic profiling of alpha 1-adrenergic receptor subtypes by oligonucleotide microarrays: coupling to interleukin-6 secretion but differences in STAT3 phosphorylation and gp-130". Mol. Pharmacol. 63 (5): 1104–16. PMID 12695539.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pupo AS, Minneman KP (2004). "Specific interactions between gC1qR and alpha1-adrenoceptor subtypes". J. Recept. Signal Transduct. Res. 23 (2–3): 185–95. PMID 14626446.
• Hague C, Uberti MA, Chen Z; et al. (2004). "Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors". J. Biol. Chem. 279 (15): 15541–9. doi:10.1074/jbc.M314014200. PMID 14736874.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kang SK, Yi KS, Kwon NS; et al. (2004). "Alpha1B-adrenoceptor signaling and cell motility: GTPase function of Gh/transglutaminase 2 inhibits cell migration through interaction with cytoplasmic tail of integrin alpha subunits". J. Biol. Chem. 279 (35): 36593–600. doi:10.1074/jbc.M402084200. PMID 15220331.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gonzalez-Cabrera PJ, Shi T, Yun J; et al. (2004). "Differential regulation of the cell cycle by alpha1-adrenergic receptor subtypes". Endocrinology. 145 (11): 5157–67. doi:10.1210/en.2004-0728. PMID 15297446.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang T, Xu Q, Chen FR; et al. (2005). "Yeast two-hybrid screening for proteins that interact with alpha1-adrenergic receptors". Acta Pharmacol. Sin. 25 (11): 1471–8. PMID 15525470.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)