Alpha-2A adrenergic receptor

Adrenergic, alpha-2A-, receptor
PDB rendering based on 1hll.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1hll​, 1ho9​, 1hod​, 1hof​
Identifiers
Symbols	ADRA2A ; ADRA2; ADRA2R; ADRAR; ALPHA2AAR; ZNF32
External IDs	Template:OMIM5 Template:MGI HomoloGene: 47944
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

The alpha-2A adrenergic receptor (α_2A adrenoreceptor), also known as ADRA2A, is an alpha-2 adrenergic receptor, and also denotes the human gene encoding it.

Receptor

Alpha-2-adrenergic receptors include 3 highly homologous subtypes: alpha_2A, alpha_2B, and alpha_2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha_2A and alpha_2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha_2C subtype modulated neurotransmission at lower levels of nerve activity.

Gene

This gene encodes alpha_2A subtype and it contains no introns in either its coding or untranslated sequences.

See also

• Adrenergic receptor

Further reading

• Perälä M, Hirvonen H, Kalimo H; et al. (1993). "Differential expression of two alpha 2-adrenergic receptor subtype mRNAs in human tissues". Brain Res. Mol. Brain Res. 16 (1–2): 57–63. PMID 1334200.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Surprenant A, Horstman DA, Akbarali H, Limbird LE (1992). "A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents". Science. 257 (5072): 977–80. PMID 1354394.CS1 maint: Multiple names: authors list (link)
• Handy DE, Gavras H (1992). "Promoter region of the human alpha 2A adrenergic receptor gene". J. Biol. Chem. 267 (33): 24017–22. PMID 1385431.
• Suryanarayana S, Daunt DA, Von Zastrow M, Kobilka BK (1991). "A point mutation in the seventh hydrophobic domain of the alpha 2 adrenergic receptor increases its affinity for a family of beta receptor antagonists". J. Biol. Chem. 266 (23): 15488–92. PMID 1678390.CS1 maint: Multiple names: authors list (link)
• Wang CD, Buck MA, Fraser CM (1991). "Site-directed mutagenesis of alpha 2A-adrenergic receptors: identification of amino acids involved in ligand binding and receptor activation by agonists". Mol. Pharmacol. 40 (2): 168–79. PMID 1678850.CS1 maint: Multiple names: authors list (link)
• Chhajlani V, Rangel N, Uhlén S, Wikberg JE (1991). "Identification of an additional gene belonging to the alpha 2 adrenergic receptor family in the human genome by PCR". FEBS Lett. 280 (2): 241–4. PMID 1849485.CS1 maint: Multiple names: authors list (link)
• Guyer CA, Horstman DA, Wilson AL; et al. (1990). "Cloning, sequencing, and expression of the gene encoding the porcine alpha 2-adrenergic receptor. Allosteric modulation by Na+, H+, and amiloride analogs". J. Biol. Chem. 265 (28): 17307–17. PMID 2170371.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fraser CM, Arakawa S, McCombie WR, Venter JC (1989). "Cloning, sequence analysis, and permanent expression of a human alpha 2-adrenergic receptor in Chinese hamster ovary cells. Evidence for independent pathways of receptor coupling to adenylate cyclase attenuation and activation". J. Biol. Chem. 264 (20): 11754–61. PMID 2568356.CS1 maint: Multiple names: authors list (link)
• Kobilka BK, Matsui H, Kobilka TS; et al. (1987). "Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor". Science. 238 (4827): 650–6. PMID 2823383.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lynch CJ, Steer ML (1981). "Evidence for high and low affinity alpha 2-receptors. Comparison of [3H]norepinephrine and [3H]phentolamine binding to human platelet membranes". J. Biol. Chem. 256 (7): 3298–303. PMID 6259160.
• Eason MG, Moreira SP, Liggett SB (1995). "Four consecutive serines in the third intracellular loop are the sites for beta-adrenergic receptor kinase-mediated phosphorylation and desensitization of the alpha 2A-adrenergic receptor". J. Biol. Chem. 270 (9): 4681–8. PMID 7876239.CS1 maint: Multiple names: authors list (link)
• Grassie MA, Milligan G (1995). "Analysis of the relative interactions between the alpha 2C10 adrenoceptor and the guanine-nucleotide-binding proteins G(o)1 alpha and Gi 2 alpha following co-expression of these polypeptides in rat 1 fibroblasts". Biochem. J. 306 ( Pt 2): 525–30. PMID 7887906.
• Shilo L, Sakaue M, Thomas JM; et al. (1994). "Enhanced transcription of the human alpha 2A-adrenergic receptor gene by cAMP: evidence for multiple cAMP responsive sequences in the promoter region of this gene". Cell. Signal. 6 (1): 73–82. PMID 8011430.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Valet P, Senard JM, Devedjian JC; et al. (1993). "Characterization and distribution of alpha 2-adrenergic receptors in the human intestinal mucosa". J. Clin. Invest. 91 (5): 2049–57. PMID 8098045.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Alblas J, van Corven EJ, Hordijk PL; et al. (1993). "Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts". J. Biol. Chem. 268 (30): 22235–8. PMID 8226727.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Klein U, Ramirez MT, Kobilka BK, von Zastrow M (1997). "A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B". J. Biol. Chem. 272 (31): 19099–102. PMID 9235896.CS1 maint: Multiple names: authors list (link)
• Bétuing S, Daviaud D, Pagès C; et al. (1998). "Gbeta gamma-independent coupling of alpha2-adrenergic receptor to p21(rhoA) in preadipocytes". J. Biol. Chem. 273 (25): 15804–10. PMID 9624180.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Prezeau L, Richman JG, Edwards SW, Limbird LE (1999). "The zeta isoform of 14-3-3 proteins interacts with the third intracellular loop of different alpha2-adrenergic receptor subtypes". J. Biol. Chem. 274 (19): 13462–9. PMID 10224112.CS1 maint: Multiple names: authors list (link)
• Hein L, Altman JD, Kobilka BK (2000). "Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission". Nature. 402 (6758): 181–4. doi:10.1038/46040. PMID 10647009.CS1 maint: Multiple names: authors list (link)
• Schaak S, Cussac D, Cayla C; et al. (2000). "Alpha(2) adrenoceptors regulate proliferation of human intestinal epithelial cells". Gut. 47 (2): 242–50. PMID 10896916.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)