Tachykinin receptor 2
| Tachykinin receptor 2 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | TACR2 ; NK2R; NKNAR; SKR; TAC2R | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 55548 | ||||||||||
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| File:PBB GE TACR2 214348 at tn.png | |||||||||||
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| Species | Human | Mouse | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
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Tachykinin receptor 2, also known as TACR2, is a human gene.[1]
This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A.[1]
See also
References
Further reading
- Maggi CA, Giuliani S, Patacchini R; et al. (1992). "Tachykinin antagonists inhibit nerve-mediated contractions in the circular muscle of the human ileum. Involvement of neurokinin-2 receptors". Gastroenterology. 102 (1): 88–96. PMID 1370160.
- Gerard NP, Gerard C (1991). "Molecular cloning of the human neurokinin-2 receptor cDNA by polymerase chain reaction and isolation of the gene". Ann. N. Y. Acad. Sci. 632: 389–90. PMID 1659296.
- Cyr C, South V, Saltzman A; et al. (1991). "Cloning, expression of the human substance K receptor, and analysis of its role in mitogenesis". Ann. N. Y. Acad. Sci. 632: 426–7. PMID 1659297.
- Morten JE, Hopkins B, Powell SJ, Graham A (1992). "Human NK-2 receptor gene maps to chromosome region 10q11-21". Hum. Genet. 88 (2): 200–3. PMID 1661704.
- Graham A, Hopkins B, Powell SJ; et al. (1991). "Isolation and characterisation of the human lung NK-2 receptor gene using rapid amplification of cDNA ends". Biochem. Biophys. Res. Commun. 177 (1): 8–16. PMID 1710456.
- Gerard NP, Eddy RL, Shows TB, Gerard C (1991). "The human neurokinin A (substance K) receptor. Molecular cloning of the gene, chromosome localization, and isolation of the cDNA from tracheal and gastric tissues". J. Biol. Chem. 266 (2): 1354. PMID 1845990.
- Kris RM, South V, Saltzman A; et al. (1991). "Cloning and expression of the human substance K receptor and analysis of its role in mitogenesis". Cell Growth Differ. 2 (1): 15–22. PMID 1848773.
- Gerard NP, Eddy RL, Shows TB, Gerard C (1990). "The human neurokinin A (substance K) receptor. Molecular cloning of the gene, chromosome localization, and isolation of cDNA from tracheal and gastric tissues". J. Biol. Chem. 265 (33): 20455–62. PMID 2173708.
- Alblas J, van Etten I, Khanum A, Moolenaar WH (1995). "C-terminal truncation of the neurokinin-2 receptor causes enhanced and sustained agonist-induced signaling. Role of receptor phosphorylation in signal attenuation". J. Biol. Chem. 270 (15): 8944–51. PMID 7721803.
- Bhogal N, Donnelly D, Findlay JB (1994). "The ligand binding site of the neurokinin 2 receptor. Site-directed mutagenesis and identification of neurokinin A binding residues in the human neurokinin 2 receptor". J. Biol. Chem. 269 (44): 27269–74. PMID 7961636.
- Arkinstall S, Emergy I, Church D; et al. (1994). "Calcium influx and protein kinase C alpha activation mediate arachidonic acid mobilization by the human NK-2 receptor expressed in Chinese hamster ovary cells". FEBS Lett. 338 (1): 75–80. PMID 8307161.
- Brunelleschi S, Bordin G, Colangelo D, Viano I (1999). "Tachykinin receptors on human monocytes: their involvement in rheumatoid arthritis". Neuropeptides. 32 (3): 215–23. PMID 10189055.
- Patacchini R, Giuliani S, Turini A; et al. (2000). "Effect of nepadutant at tachykinin NK(2) receptors in human intestine and urinary bladder". Eur. J. Pharmacol. 398 (3): 389–97. PMID 10862829.
- Bellucci F, Carini F, Catalani C; et al. (2002). "Pharmacological profile of the novel mammalian tachykinin, hemokinin 1". Br. J. Pharmacol. 135 (1): 266–74. doi:10.1038/sj.bjp.0704443. PMID 11786503.
- Patacchini R, Barbagli G, Palminteri E; et al. (2002). "Tachykinin NK1 and NK2 receptors mediate inhibitory vs excitatory motor responses in human isolated corpus cavernosum and spongiosum". Br. J. Pharmacol. 135 (6): 1351–4. doi:10.1038/sj.bjp.0704650. PMID 11906947.
- Candenas ML, Cintado CG, Pennefather JN; et al. (2002). "Identification of a tachykinin NK(2) receptor splice variant and its expression in human and rat tissues". Life Sci. 72 (3): 269–77. PMID 12427486.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Bandari PS, Qian J, Oh HS; et al. (2003). "Crosstalk between neurokinin receptors is relevant to hematopoietic regulation: cloning and characterization of neurokinin-2 promoter". J. Neuroimmunol. 138 (1–2): 65–75. PMID 12742655.
- Zhao A, Shea-Donohue T (2003). "PAR-2 agonists induce contraction of murine small intestine through neurokinin receptors". Am. J. Physiol. Gastrointest. Liver Physiol. 285 (4): G696–703. doi:10.1152/ajpgi.00064.2003. PMID 12801882.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.