5-HT1B receptor

5-hydroxytryptamine (serotonin) receptor 1B
Identifiers
Symbols	HTR1B ; 5-HT1B; 5-HT1DB; HTR1D2; HTR1DB; S12
External IDs	Template:OMIM5 Template:MGI HomoloGene: 669
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

5-hydroxytryptamine (serotonin) receptor 1B, also known as HTR1B, is a human 5-HT receptor, but also denotes the gene encoding it.

Tissue distribution and function

5-HT_1B acts on the CNS, where it induces presynaptic inhibition and behavioural effects. It also has vascular effects, such as pulmonary vasoconstriction.

5-HT_1B receptors are present in many parts of the human brain. The highest concentrations are found in the basal ganglia, striatum and the frontal cortex. The function of the receptor differs between the areas: in the frontal lobes it is believed to act as an terminal receptor, inhibiting the release of dopamine. In the striatum and the basal ganglia, the 5-HT_1B receptor is thought to act as an autoreceptor, inhibiting the release of serotonin.

Knockout mice lacking the 5-HT_1B gene has shown an increase of aggression and a higher preference for alcohol.

Ligands

Agonists	Antagonists
ergotamine (vasoconstrictor in migraine) sumatriptan (vasoconstrictor in migraine) 5-carboxamidotryptamine (5-CT)	methiothepin (antipsychotic) yohimbine (aphrodisiac) metergoline

See also

• 5-HT₁ receptor
• 5-HT receptor

Further reading

• Olivier B, van Oorschot R (2006). "5-HT1B receptors and aggression: a review". Eur. J. Pharmacol. 526 (1–3): 207–17. doi:10.1016/j.ejphar.2005.09.066. PMID 16310769.
• Hamblin MW, Metcalf MA, McGuffin RW, Karpells S (1992). "Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity". Biochem. Biophys. Res. Commun. 184 (2): 752–9. PMID 1315531.CS1 maint: Multiple names: authors list (link)
• Veldman SA, Bienkowski MJ (1992). "Cloning and pharmacological characterization of a novel human 5-hydroxytryptamine1D receptor subtype". Mol. Pharmacol. 42 (3): 439–44. PMID 1328844.
• Jin H, Oksenberg D, Ashkenazi A; et al. (1992). "Characterization of the human 5-hydroxytryptamine1B receptor". J. Biol. Chem. 267 (9): 5735–8. PMID 1348246.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Demchyshyn L, Sunahara RK, Miller K; et al. (1992). "A human serotonin 1D receptor variant (5HT1D beta) encoded by an intronless gene on chromosome 6". Proc. Natl. Acad. Sci. U.S.A. 89 (12): 5522–6. PMID 1351684.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Levy FO, Gudermann T, Perez-Reyes E; et al. (1992). "Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype". J. Biol. Chem. 267 (11): 7553–62. PMID 1559993.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Weinshank RL, Zgombick JM, Macchi MJ; et al. (1992). "Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta". Proc. Natl. Acad. Sci. U.S.A. 89 (8): 3630–4. PMID 1565658.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mochizuki D, Yuyama Y, Tsujita R; et al. (1992). "Cloning and expression of the human 5-HT1B-type receptor gene". Biochem. Biophys. Res. Commun. 185 (2): 517–23. PMID 1610347.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nöthen MM, Erdmann J, Shimron-Abarbanell D, Propping P (1995). "Identification of genetic variation in the human serotonin 1D beta receptor gene". Biochem. Biophys. Res. Commun. 205 (2): 1194–200. PMID 7802650.CS1 maint: Multiple names: authors list (link)
• Ng GY, George SR, Zastawny RL; et al. (1993). "Human serotonin1B receptor expression in Sf9 cells: phosphorylation, palmitoylation, and adenylyl cyclase inhibition". Biochemistry. 32 (43): 11727–33. PMID 8218242.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bouchelet I, Cohen Z, Case B; et al. (1996). "Differential expression of sumatriptan-sensitive 5-hydroxytryptamine receptors in human trigeminal ganglia and cerebral blood vessels". Mol. Pharmacol. 50 (2): 219–23. PMID 8700126.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sanders AR, Cao Q, Taylor J; et al. (2001). "Genetic diversity of the human serotonin receptor 1B (HTR1B) gene". Genomics. 72 (1): 1–14. doi:10.1006/geno.2000.6411. PMID 11247661.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Varnäs K, Hall H, Bonaventure P, Sedvall G (2001). "Autoradiographic mapping of 5-HT(1B) and 5-HT(1D) receptors in the post mortem human brain using [(3)H]GR 125743". Brain Res. 915 (1): 47–57. PMID 11578619.CS1 maint: Multiple names: authors list (link)
• Salim K, Fenton T, Bacha J; et al. (2002). "Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation". J. Biol. Chem. 277 (18): 15482–5. doi:10.1074/jbc.M201539200. PMID 11854302.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hasegawa Y, Higuchi S, Matsushita S, Miyaoka H (2002). "Association of a polymorphism of the serotonin 1B receptor gene and alcohol dependence with inactive aldehyde dehydrogenase-2". Journal of neural transmission (Vienna, Austria : 1996). 109 (4): 513–21. doi:10.1007/s007020200042. PMID 11956970.CS1 maint: Multiple names: authors list (link)
• Hawi Z, Dring M, Kirley A; et al. (2003). "Serotonergic system and attention deficit hyperactivity disorder (ADHD): a potential susceptibility locus at the 5-HT(1B) receptor gene in 273 nuclear families from a multi-centre sample". Mol. Psychiatry. 7 (7): 718–25. doi:10.1038/sj.mp.4001048. PMID 12192616.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Huang YY, Oquendo MA, Friedman JM; et al. (2003). "Substance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism". Neuropsychopharmacology. 28 (1): 163–9. doi:10.1038/sj.npp.1300000. PMID 12496953.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Quist JF, Barr CL, Schachar R; et al. (2003). "The serotonin 5-HT1B receptor gene and attention deficit hyperactivity disorder". Mol. Psychiatry. 8 (1): 98–102. doi:10.1038/sj.mp.4001244. PMID 12556913.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sinha R, Cloninger CR, Parsian A (2003). "Linkage disequilibrium and haplotype analysis between serotonin receptor 1B gene variations and subtypes of alcoholism". Am. J. Med. Genet. B Neuropsychiatr. Genet. 121 (1): 83–8. doi:10.1002/ajmg.b.20064. PMID 12898580.CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.