Alpha-2B adrenergic receptor

Adrenergic, alpha-2B-, receptor
Identifiers
Symbols	ADRA2B ; ADRA2L1; ADRA2RL1; ADRARL1; ALPHA2BAR
External IDs	Template:OMIM5 Template:MGI HomoloGene: 553
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

The alpha-2B adrenergic receptor (α_2B adrenoreceptor), also known as ADRA2B, is an alpha-2 adrenergic receptor, and also denotes the human gene encoding it.

Receptor

Alpha-2-adrenergic receptors include 3 highly homologous subtypes: alpha_2A, alpha_2B, and alpha_2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system.

Gene

This gene encodes the alpha_2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha_2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. This gene contains no introns in either its coding or untranslated sequences.

See also

• Adrenergic receptor

Further reading

• Lomasney JW, Lorenz W, Allen LF; et al. (1990). "Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2". Proc. Natl. Acad. Sci. U.S.A. 87 (13): 5094–8. PMID 2164221.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McClue SJ, Milligan G (1990). "The alpha 2B adrenergic receptor of undifferentiated neuroblastoma x glioma hybrid NG108-15 cells, interacts directly with the guanine nucleotide binding protein, Gi2". FEBS Lett. 269 (2): 430–4. PMID 2169434.
• Weinshank RL, Zgombick JM, Macchi M; et al. (1990). "Cloning, expression, and pharmacological characterization of a human alpha 2B-adrenergic receptor". Mol. Pharmacol. 38 (5): 681–8. PMID 2172775.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chang AC, Ho TF, Chang NC (1990). "In vitro amplification by polymerase chain reaction of a partial gene encoding the third subtype of alpha-2 adrenergic receptor in humans". Biochem. Biophys. Res. Commun. 172 (2): 817–23. PMID 2173582.CS1 maint: Multiple names: authors list (link)
• Regan JW, Kobilka TS, Yang-Feng TL; et al. (1988). "Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype". Proc. Natl. Acad. Sci. U.S.A. 85 (17): 6301–5. PMID 2842764.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Petrash AC, Bylund DB (1986). "Alpha-2 adrenergic receptor subtypes indicated by [3H]yohimbine binding in human brain". Life Sci. 38 (23): 2129–37. PMID 3012234.
• Klein U, Ramirez MT, Kobilka BK, von Zastrow M (1997). "A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B". J. Biol. Chem. 272 (31): 19099–102. PMID 9235896.CS1 maint: Multiple names: authors list (link)
• Okusa MD, Huang L, Momose-Hotokezaka A; et al. (1998). "Regulation of adenylyl cyclase in polarized renal epithelial cells by G protein-coupled receptors". Am. J. Physiol. 273 (6 Pt 2): F883–91. PMID 9435676.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Prezeau L, Richman JG, Edwards SW, Limbird LE (1999). "The zeta isoform of 14-3-3 proteins interacts with the third intracellular loop of different alpha2-adrenergic receptor subtypes". J. Biol. Chem. 274 (19): 13462–9. PMID 10224112.CS1 maint: Multiple names: authors list (link)
• Heinonen P, Koulu M, Pesonen U; et al. (1999). "Identification of a three-amino acid deletion in the alpha2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects". J. Clin. Endocrinol. Metab. 84 (7): 2429–33. PMID 10404816.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hein L, Altman JD, Kobilka BK (2000). "Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission". Nature. 402 (6758): 181–4. doi:10.1038/46040. PMID 10647009.CS1 maint: Multiple names: authors list (link)
• Small KM, Brown KM, Forbes SL, Liggett SB (2001). "Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization". J. Biol. Chem. 276 (7): 4917–22. doi:10.1074/jbc.M008118200. PMID 11056163.CS1 maint: Multiple names: authors list (link)
• Snapir A, Mikkelsson J, Perola M; et al. (2003). "Variation in the alpha2B-adrenoceptor gene as a risk factor for prehospital fatal myocardial infarction and sudden cardiac death". J. Am. Coll. Cardiol. 41 (2): 190–4. PMID 12535806.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sykiotis GP, Polyzogopoulou E, Georgopoulos NA; et al. (2004). "The alpha2B adrenergic receptor deletion/insertion polymorphism in morbid obesity". Clin. Auton. Res. 13 (3): 203–7. doi:10.1007/s10286-003-0087-5. PMID 12822042.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chotani MA, Mitra S, Su BY; et al. (2004). "Regulation of alpha(2)-adrenoceptors in human vascular smooth muscle cells". Am. J. Physiol. Heart Circ. Physiol. 286 (1): H59–67. doi:10.1152/ajpheart.00268.2003. PMID 12946937.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Von Wowern F, Bengtsson K, Lindblad U; et al. (2004). "Functional variant in the (alpha)2B adrenoceptor gene, a positional candidate on chromosome 2, associates with hypertension". Hypertension. 43 (3): 592–7. doi:10.1161/01.HYP.0000116224.51189.80. PMID 14744925.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cayla C, Heinonen P, Viikari L; et al. (2004). "Cloning, characterisation and identification of several polymorphisms in the promoter region of the human alpha2B-adrenergic receptor gene". Biochem. Pharmacol. 67 (3): 469–78. doi:10.1016/j.bcp.2003.09.029. PMID 15037199.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Phares DA, Halverstadt AA, Shuldiner AR; et al. (2004). "Association between body fat response to exercise training and multilocus ADR genotypes". Obes. Res. 12 (5): 807–15. PMID 15166301.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Siitonen N, Lindström J, Eriksson J; et al. (2005). "Association between a deletion/insertion polymorphism in the alpha2B-adrenergic receptor gene and insulin secretion and Type 2 diabetes. The Finnish Diabetes Prevention Study". Diabetologia. 47 (8): 1416–24. doi:10.1007/s00125-004-1462-z. PMID 15309292.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Belfer I, Buzas B, Hipp H; et al. (2005). "Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each gene". J. Hum. Genet. 50 (1): 12–20. doi:10.1007/s10038-004-0211-y. PMID 15592690.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)