Beta-3 adrenergic receptor
| Adrenergic, beta-3-, receptor | |||
|---|---|---|---|
| Identifiers | |||
| Symbols | ADRB3 ; BETA3AR | ||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 37250 | ||
| RNA expression pattern | |||
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| More reference expression data | |||
| Orthologs | |||
| Template:GNF Ortholog box | |||
| Species | Human | Mouse | |
| Entrez | n/a | n/a | |
| Ensembl | n/a | n/a | |
| UniProt | n/a | n/a | |
| RefSeq (mRNA) | n/a | n/a | |
| RefSeq (protein) | n/a | n/a | |
| Location (UCSC) | n/a | n/a | |
| PubMed search | n/a | n/a | |
The beta-3 adrenergic receptor (β3 adrenoreceptor), also known as ADRB3, is an beta-adrenergic receptor, and also denotes the human gene encoding it.[1]
Receptor
Functions
Actions of the β3 receptor include:
- Enhancement of lipolysis in adipose tissue.
- Thermogenesis in skeletal muscle[2]
It is located mainly in adipose tissue and is involved in the regulation of lipolysis and thermogenesis.
Mechanism
Beta adrenergic receptors are involved in the epinephrine and norepinephrine-induced activation of adenylate cyclase through the action of the G proteins of the type Gs.[1]
Agonists
- L-796568[3]
- CL 316,243
- LY 368842
- Ro 40-2148
Antagonists
See also
- Other adrenergic receptors
References
- ↑ 1.0 1.1 "Entrez Gene: ADRB1 adrenergic, beta-1-, receptor".
- ↑ Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4. Page 163
- ↑ Larsen TM, Toubro S, van Baak MA, Gottesdiener KM, Larson P, Saris WH, Astrup A (2002). "Effect of a 28-d treatment with L-796568, a novel β3-adrenergic receptor agonist, on energy expenditure and body composition in obese men". Am. J. Clin. Nutr. 76 (4): 780–8. PMID 12324291.
- ↑ Nisoli E, Tonello C, Landi M, Carruba MO (1996). "Functional studies of the first selective β3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes". Mol. Pharmacol. 49 (1): 7–14. PMID 8569714.
Further reading
- Granneman JG, Lahners KN, Rao DD (1993). "Rodent and human beta 3-adrenergic receptor genes contain an intron within the protein-coding block". Mol. Pharmacol. 42 (6): 964–70. PMID 1336117.
- Nahmias C, Blin N, Elalouf JM; et al. (1991). "Molecular characterization of the mouse beta 3-adrenergic receptor: relationship with the atypical receptor of adipocytes". EMBO J. 10 (12): 3721–7. PMID 1718744.
- Emorine LJ, Marullo S, Briend-Sutren MM; et al. (1989). "Molecular characterization of the human beta 3-adrenergic receptor". Science. 245 (4922): 1118–21. PMID 2570461.
- Guan XM, Amend A, Strader CD (1995). "Determination of structural domains for G protein coupling and ligand binding in beta 3-adrenergic receptor". Mol. Pharmacol. 48 (3): 492–8. PMID 7565630.
- Rodriguez M, Carillon C, Coquerel A; et al. (1995). "Evidence for the presence of beta 3-adrenergic receptor mRNA in the human brain". Brain Res. Mol. Brain Res. 29 (2): 369–75. PMID 7609625.
- Clément K, Vaisse C, Manning BS; et al. (1995). "Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity". N. Engl. J. Med. 333 (6): 352–4. PMID 7609752.
- Dib A, Adélaïde J, Chaffanet M; et al. (1995). "Characterization of the region of the short arm of chromosome 8 amplified in breast carcinoma". Oncogene. 10 (5): 995–1001. PMID 7898940.
- Mahmoudian M (1994). "The complex of human Gs protein with the beta 3 adrenergic receptor: a computer-aided molecular modeling study". Journal of molecular graphics. 12 (1): 22–8, 34. PMID 8011597.
- Wilkie TM, Chen Y, Gilbert DJ; et al. (1994). "Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors". Genomics. 18 (2): 175–84. doi:10.1006/geno.1993.1452. PMID 8288218.
- Krief S, Lönnqvist F, Raimbault S; et al. (1993). "Tissue distribution of beta 3-adrenergic receptor mRNA in man". J. Clin. Invest. 91 (1): 344–9. PMID 8380813.
- van Spronsen A, Nahmias C, Krief S; et al. (1993). "The promoter and intron/exon structure of the human and mouse beta 3-adrenergic-receptor genes". Eur. J. Biochem. 213 (3): 1117–24. PMID 8389293.
- Lelias JM, Kaghad M, Rodriguez M; et al. (1993). "Molecular cloning of a human beta 3-adrenergic receptor cDNA". FEBS Lett. 324 (2): 127–30. PMID 8389717.
- Candelore MR, Deng L, Tota LM; et al. (1996). "Pharmacological characterization of a recently described human beta 3-adrenergic receptor mutant". Endocrinology. 137 (6): 2638–41. PMID 8641219.
- Fujisawa T, Ikegami H, Yamato E; et al. (1996). "Association of Trp64Arg mutation of the beta3-adrenergic-receptor with NIDDM and body weight gain". Diabetologia. 39 (3): 349–52. PMID 8721782.
- Higashi K, Ishikawa T, Ito T; et al. (1997). "Association of a genetic variation in the beta 3-adrenergic receptor gene with coronary heart disease among Japanese". Biochem. Biophys. Res. Commun. 232 (3): 728–30. doi:10.1006/bbrc.1997.6339. PMID 9126344.
- Hoffstedt J, Poirier O, Thörne A; et al. (1999). "Polymorphism of the human beta3-adrenoceptor gene forms a well-conserved haplotype that is associated with moderate obesity and altered receptor function". Diabetes. 48 (1): 203–5. PMID 9892244.
- Halushka MK, Fan JB, Bentley K; et al. (1999). "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis". Nat. Genet. 22 (3): 239–47. doi:10.1038/10297. PMID 10391210.
- Kimura K, Sasaki N, Asano A; et al. (2000). "Mutated human beta3-adrenergic receptor (Trp64Arg) lowers the response to beta3-adrenergic agonists in transfected 3T3-L1 preadipocytes". Horm. Metab. Res. 32 (3): 91–6. PMID 10786926.
- Cao W, Luttrell LM, Medvedev AV; et al. (2001). "Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation". J. Biol. Chem. 275 (49): 38131–4. doi:10.1074/jbc.C000592200. PMID 11013230.
- Russell ST, Hirai K, Tisdale MJ (2002). "Role of beta3-adrenergic receptors in the action of a tumour lipid mobilizing factor". Br. J. Cancer. 86 (3): 424–8. doi:10.1038/sj.bjc.6600086. PMID 11875710.