Cysteinyl leukotriene receptor 1
| Cysteinyl leukotriene receptor 1 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | CYSLTR1 ; CYSLT1; CYSLT1R; CYSLTR; HG55; HMTMF81; MGC46139 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 4837 | ||||||||||
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| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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Cysteinyl leukotriene receptor 1, also known as CYSLTR1, is a human gene.[1]
The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR2. This encoded receptor is a member of the superfamily of G protein-coupled receptors. Activation of this receptor by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung.[1]
See also
References
Further reading
- Lynch KR, O'Neill GP, Liu Q; et al. (1999). "Characterization of the human cysteinyl leukotriene CysLT1 receptor". Nature. 399 (6738): 789–93. doi:10.1038/21658. PMID 10391245.
- Sarau HM, Ames RS, Chambers J; et al. (1999). "Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor". Mol. Pharmacol. 56 (3): 657–63. PMID 10462554.
- Gronert K, Martinsson-Niskanen T, Ravasi S; et al. (2001). "Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses". Am. J. Pathol. 158 (1): 3–9. PMID 11141472.
- Sjöström M, Jakobsson PJ, Heimburger M; et al. (2001). "Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor". Eur. J. Biochem. 268 (9): 2578–86. PMID 11322876.
- Mellor EA, Maekawa A, Austen KF, Boyce JA (2001). "Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells". Proc. Natl. Acad. Sci. U.S.A. 98 (14): 7964–9. doi:10.1073/pnas.141221498. PMID 11438743.
- Mita H, Hasegawa M, Saito H, Akiyama K (2002). "Levels of cysteinyl leukotriene receptor mRNA in human peripheral leucocytes: significantly higher expression of cysteinyl leukotriene receptor 2 mRNA in eosinophils". Clin. Exp. Allergy. 31 (11): 1714–23. PMID 11696047.
- Shirasaki H, Kanaizumi E, Watanabe K; et al. (2003). "Expression and localization of the cysteinyl leukotriene 1 receptor in human nasal mucosa". Clin. Exp. Allergy. 32 (7): 1007–12. PMID 12100046.
- Ohshima N, Nagase H, Koshino T; et al. (2002). "A functional study on CysLT(1) receptors in human eosinophils". Int. Arch. Allergy Immunol. 129 (1): 67–75. PMID 12373000.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Ohd JF, Nielsen CK, Campbell J; et al. (2003). "Expression of the leukotriene D4 receptor CysLT1, COX-2, and other cell survival factors in colorectal adenocarcinomas". Gastroenterology. 124 (1): 57–70. doi:10.1053/gast.2003.50011. PMID 12512030.
- Chibana K, Ishii Y, Asakura T, Fukuda T (2003). "Up-regulation of cysteinyl leukotriene 1 receptor by IL-13 enables human lung fibroblasts to respond to leukotriene C4 and produce eotaxin". J. Immunol. 170 (8): 4290–5. PMID 12682264.
- Espinosa K, Bossé Y, Stankova J, Rola-Pleszczynski M (2003). "CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4". J. Allergy Clin. Immunol. 111 (5): 1032–40. PMID 12743568.
- Walch L, Norel X, Gascard JP, Brink C (2003). "Arachidonic acid inhibits cysteinyl-leukotriene receptor activation in human pulmonary vessels". Adv. Exp. Med. Biol. 525: 75–9. PMID 12751740.
- Nielsen CK, Ohd JF, Wikström K; et al. (2003). "The leukotriene receptor CysLT1 and 5-lipoxygenase are upregulated in colon cancer". Adv. Exp. Med. Biol. 525: 201–4. PMID 12751768.
- Mechiche H, Naline E, Candenas L; et al. (2003). "Effects of cysteinyl leukotrienes in small human bronchus and antagonist activity of montelukast and its metabolites". Clin. Exp. Allergy. 33 (7): 887–94. PMID 12859443.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Yang G, Haczku A, Chen H; et al. (2004). "Transgenic smooth muscle expression of the human CysLT1 receptor induces enhanced responsiveness of murine airways to leukotriene D4". Am. J. Physiol. Lung Cell Mol. Physiol. 286 (5): L992–1001. doi:10.1152/ajplung.00367.2003. PMID 15064240.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Naik S, Billington CK, Pascual RM; et al. (2005). "Regulation of cysteinyl leukotriene type 1 receptor internalization and signaling". J. Biol. Chem. 280 (10): 8722–32. doi:10.1074/jbc.M413014200. PMID 15590629.
- Corrigan C, Mallett K, Ying S; et al. (2005). "Expression of the cysteinyl leukotriene receptors cysLT(1) and cysLT(2) in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis". J. Allergy Clin. Immunol. 115 (2): 316–22. doi:10.1016/j.jaci.2004.10.051. PMID 15696087.
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