GPR4

G protein-coupled receptor 4
Identifiers
Symbols	GPR4 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3867
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

G protein-coupled receptor 4, also known as GPR4, is a human gene.

Further reading

• An S, Tsai C, Goetzl EJ (1996). "Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue". FEBS Lett. 375 (1–2): 121–4. PMID 7498459.CS1 maint: Multiple names: authors list (link)
• Heiber M, Docherty JM, Shah G; et al. (1995). "Isolation of three novel human genes encoding G protein-coupled receptors". DNA Cell Biol. 14 (1): 25–35. PMID 7832990.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mahadevan MS, Baird S, Bailly JE; et al. (1996). "Isolation of a novel G protein-coupled receptor (GPR4) localized to chromosome 19q13.3". Genomics. 30 (1): 84–8. doi:10.1006/geno.1995.0013. PMID 8595909.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhu K, Baudhuin LM, Hong G; et al. (2001). "Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4". J. Biol. Chem. 276 (44): 41325–35. doi:10.1074/jbc.M008057200. PMID 11535583.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lum H, Qiao J, Walter RJ; et al. (2003). "Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells". Am. J. Physiol. Heart Circ. Physiol. 285 (4): H1786–9. doi:10.1152/ajpheart.00359.2003. PMID 12805023.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ludwig MG, Vanek M, Guerini D; et al. (2003). "Proton-sensing G-protein-coupled receptors". Nature. 425 (6953): 93–8. doi:10.1038/nature01905. PMID 12955148.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bektas M, Barak LS, Jolly PS; et al. (2003). "The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner". Biochemistry. 42 (42): 12181–91. doi:10.1021/bi035051y. PMID 14567679.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sin WC, Zhang Y, Zhong W; et al. (2004). "G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers". Oncogene. 23 (37): 6299–303. doi:10.1038/sj.onc.1207838. PMID 15221007.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim KS, Ren J, Jiang Y; et al. (2005). "GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine". FASEB J. 19 (7): 819–21. doi:10.1096/fj.04-2988fje. PMID 15857892.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Qiao J, Huang F, Naikawadi RP; et al. (2006). "Lysophosphatidylcholine impairs endothelial barrier function through the G protein-coupled receptor GPR4". Am. J. Physiol. Lung Cell Mol. Physiol. 291 (1): L91–101. doi:10.1152/ajplung.00508.2005. PMID 16461426.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Huang F, Mehta D, Predescu S; et al. (2007). "A novel lysophospholipid- and pH-sensitive receptor, GPR4, in brain endothelial cells regulates monocyte transmigration". Endothelium. 14 (1): 25–34. doi:10.1080/10623320601177288. PMID 17364894.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zou Y, Kim CH, Chung JH; et al. (2007). "Upregulation of endothelial adhesion molecules by lysophosphatidylcholine. Involvement of G protein-coupled receptor GPR4". FEBS J. 274 (10): 2573–84. doi:10.1111/j.1742-4658.2007.05792.x. PMID 17437524.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tobo M, Tomura H, Mogi C; et al. (2007). "Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms". Cell. Signal. 19 (8): 1745–53. doi:10.1016/j.cellsig.2007.03.009. PMID 17462861.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)