Hypocretin (orexin) receptor 2

Hypocretin (orexin) receptor 2
Identifiers
Symbols	HCRTR2 ; OX2R
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1168
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Hypocretin (orexin) receptor 2, also known as HCRTR2, is a human gene.

HCRTR2 is a G-protein coupled receptor expressed exclusively in the brain. It has 64% identity with HCRTR1. HCRTR2 binds both orexin A and orexin B neuropeptides. HCRTR2 is involved in the central feedback mechanism that regulates feeding behaviour.

See also

• Orexin receptor

Further reading

• Flier JS, Maratos-Flier E (1998). "Obesity and the hypothalamus: novel peptides for new pathways". Cell. 92 (4): 437–40. PMID 9491885.
• Willie JT, Chemelli RM, Sinton CM, Yanagisawa M (2001). "To eat or to sleep? Orexin in the regulation of feeding and wakefulness". Annu. Rev. Neurosci. 24: 429–58. doi:10.1146/annurev.neuro.24.1.429. PMID 11283317.CS1 maint: Multiple names: authors list (link)
• Hungs M, Mignot E (2001). "Hypocretin/orexin, sleep and narcolepsy". Bioessays. 23 (5): 397–408. doi:10.1002/bies.1058. PMID 11340621.
• de Lecea L, Kilduff TS, Peyron C; et al. (1998). "The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity". Proc. Natl. Acad. Sci. U.S.A. 95 (1): 322–7. PMID 9419374.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sakurai T, Amemiya A, Ishii M; et al. (1998). "Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior". Cell. 92 (4): 573–85. PMID 9491897.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sakurai T, Amemiya A, Ishii M; et al. (1998). "Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior". Cell. 92 (5): 1 page following 696. PMID 9527442.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Peyron C, Faraco J, Rogers W; et al. (2000). "A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains". Nat. Med. 6 (9): 991–7. doi:10.1038/79690. PMID 10973318.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wright GJ, Puklavec MJ, Willis AC; et al. (2000). "Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function". Immunity. 13 (2): 233–42. PMID 10981966.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.CS1 maint: Multiple names: authors list (link)
• Mazzocchi G, Malendowicz LK, Gottardo L; et al. (2001). "Orexin A stimulates cortisol secretion from human adrenocortical cells through activation of the adenylate cyclase-dependent signaling cascade". J. Clin. Endocrinol. Metab. 86 (2): 778–82. PMID 11158046.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Blanco M, López M, García-Caballero T; et al. (2001). "Cellular localization of orexin receptors in human pituitary". J. Clin. Endocrinol. Metab. 86 (4): 1616–9. PMID 11297593.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Blanco M, López M, GarcIa-Caballero T; et al. (2001). "Cellular localization of orexin receptors in human pituitary". J. Clin. Endocrinol. Metab. 86 (7): 1616–9. PMID 11443222.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Karteris E, Randeva HS, Grammatopoulos DK; et al. (2001). "Expression and coupling characteristics of the CRH and orexin type 2 receptors in human fetal adrenals". J. Clin. Endocrinol. Metab. 86 (9): 4512–9. PMID 11549701.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Randeva HS, Karteris E, Grammatopoulos D, Hillhouse EW (2001). "Expression of orexin-A and functional orexin type 2 receptors in the human adult adrenals: implications for adrenal function and energy homeostasis". J. Clin. Endocrinol. Metab. 86 (10): 4808–13. PMID 11600545.CS1 maint: Multiple names: authors list (link)
• Olafsdóttir BR, Rye DB, Scammell TE; et al. (2002). "Polymorphisms in hypocretin/orexin pathway genes and narcolepsy". Neurology. 57 (10): 1896–9. PMID 11723285.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Blanco M, García-Caballero T, Fraga M; et al. (2002). "Cellular localization of orexin receptors in human adrenal gland, adrenocortical adenomas and pheochromocytomas". Regul. Pept. 104 (1–3): 161–5. PMID 11830291.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.