Melanin-concentrating hormone receptor 1

Melanin-concentrating hormone receptor 1
Identifiers
Symbols	MCHR1 ; GPR24; MCH1R; MGC32129; SLC1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 21097
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MCHR1 221354 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Melanin-concentrating hormone receptor 1, also known as MCHR1, is one of human melanin-concentrating hormone receptors.

The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin.

See also

• Melanin-concentrating hormone receptor

Further reading

• Kolakowski LF, Jung BP, Nguyen T; et al. (1997). "Characterization of a human gene related to genes encoding somatostatin receptors". FEBS Lett. 398 (2–3): 253–8. PMID 8977118.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chambers J, Ames RS, Bergsma D; et al. (1999). "Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1". Nature. 400 (6741): 261–5. doi:10.1038/22313. PMID 10421367.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saito Y, Nothacker HP, Wang Z; et al. (1999). "Molecular characterization of the melanin-concentrating-hormone receptor". Nature. 400 (6741): 265–9. doi:10.1038/22321. PMID 10421368.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shimomura Y, Mori M, Sugo T; et al. (1999). "Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor". Biochem. Biophys. Res. Commun. 261 (3): 622–6. doi:10.1006/bbrc.1999.1104. PMID 10441476.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dunham I, Shimizu N, Roe BA; et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Macdonald D, Murgolo N, Zhang R; et al. (2000). "Molecular characterization of the melanin-concentrating hormone/receptor complex: identification of critical residues involved in binding and activation". Mol. Pharmacol. 58 (1): 217–25. PMID 10860944.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• An S, Cutler G, Zhao JJ; et al. (2001). "Identification and characterization of a melanin-concentrating hormone receptor". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7576–81. doi:10.1073/pnas.131200698. PMID 11416225.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bednarek MA, Feighner SD, Hreniuk DL; et al. (2001). "Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2". Biochemistry. 40 (31): 9379–86. PMID 11478907.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bednarek MA, Tan C, Hreniuk DL; et al. (2002). "Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1". J. Biol. Chem. 277 (16): 13821–6. doi:10.1074/jbc.M200563200. PMID 11839762.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Audinot V, Lahaye C, Suply T; et al. (2002). "SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor". Biochem. Biophys. Res. Commun. 295 (4): 841–8. PMID 12127971.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hoogduijn MJ, Ancans J, Suzuki I; et al. (2002). "Melanin-concentrating hormone and its receptor are expressed and functional in human skin". Biochem. Biophys. Res. Commun. 296 (3): 698–701. PMID 12176038.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bächner D, Kreienkamp HJ, Richter D (2002). "MIZIP, a highly conserved, vertebrate specific melanin-concentrating hormone receptor 1 interacting zinc-finger protein". FEBS Lett. 526 (1–3): 124–8. PMID 12208518.CS1 maint: Multiple names: authors list (link)
• Verlaet M, Adamantidis A, Coumans B; et al. (2002). "Human immune cells express ppMCH mRNA and functional MCHR1 receptor". FEBS Lett. 527 (1–3): 205–10. PMID 12220661.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Logan DW, Bryson-Richardson RJ, Pagán KE; et al. (2003). "The structure and evolution of the melanocortin and MCH receptors in fish and mammals". Genomics. 81 (2): 184–91. PMID 12620396.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pissios P, Trombly DJ, Tzameli I, Maratos-Flier E (2003). "Melanin-concentrating hormone receptor 1 activates extracellular signal-regulated kinase and synergizes with G(s)-coupled pathways". Endocrinology. 144 (8): 3514–23. PMID 12865333.CS1 maint: Multiple names: authors list (link)
• Gottumukkala RV, Waterman EA, Herd LM; et al. (2003). "Autoantibodies in vitiligo patients recognize multiple domains of the melanin-concentrating hormone receptor". J. Invest. Dermatol. 121 (4): 765–70. doi:10.1046/j.1523-1747.2003.12494.x. PMID 14632194.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gibson WT, Pissios P, Trombly DJ; et al. (2004). "Melanin-concentrating hormone receptor mutations and human obesity: functional analysis". Obes. Res. 12 (5): 743–9. PMID 15166293.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hawes BE, Green B, O'Neill K; et al. (2004). "Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2". Obes. Res. 12 (8): 1327–34. PMID 15340116.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Collins JE, Wright CL, Edwards CA; et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.