P2RY14
| Purinergic receptor P2Y, G-protein coupled, 14 | |||||||||||
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| Symbols | P2RY14 ; GPR105; KIAA0001; P2Y14 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 15769 | ||||||||||
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| File:PBB GE P2RY14 206637 at tn.png | |||||||||||
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| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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Purinergic receptor P2Y, G-protein coupled, 14, also known as P2RY14, is a human gene.[1]
The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene.[1]
See also
References
Further reading
- Gerard C, Gerard NP (1994). "C5A anaphylatoxin and its seven transmembrane-segment receptor". Annu. Rev. Immunol. 12: 775–808. doi:10.1146/annurev.iy.12.040194.004015. PMID 8011297.
- Müller CE (2003). "P2-pyrimidinergic receptors and their ligands". Curr. Pharm. Des. 8 (26): 2353–69. PMID 12369950.
- Abbracchio MP, Boeynaems JM, Barnard EA; et al. (2003). "Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family". Trends Pharmacol. Sci. 24 (2): 52–5. PMID 12559763.
- von Kügelgen I (2006). "Pharmacological profiles of cloned mammalian P2Y-receptor subtypes". Pharmacol. Ther. 110 (3): 415–32. doi:10.1016/j.pharmthera.2005.08.014. PMID 16257449.
- Brunschweiger A, Müller CE (2006). "P2 receptors activated by uracil nucleotides--an update". Curr. Med. Chem. 13 (3): 289–312. PMID 16475938.
- Nomura N, Miyajima N, Sazuka T; et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. PMID 7584026.
- Nomura N, Miyajima N, Sazuka T; et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. PMID 7584028.
- Charlton ME, Williams AS, Fogliano M; et al. (1997). "The isolation and characterization of a novel G protein-coupled receptor regulated by immunologic challenge". Brain Res. 764 (1–2): 141–8. PMID 9295203.
- Joensuu T, Hämäläinen R, Lehesjoki AE; et al. (2000). "A sequence-ready map of the Usher syndrome type III critical region on chromosome 3q". Genomics. 63 (3): 409–16. doi:10.1006/geno.1999.6096. PMID 10704288.
- Chambers JK, Macdonald LE, Sarau HM; et al. (2000). "A G protein-coupled receptor for UDP-glucose". J. Biol. Chem. 275 (15): 10767–71. PMID 10753868.
- Wittenberger T, Schaller HC, Hellebrand S (2001). "An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors". J. Mol. Biol. 307 (3): 799–813. doi:10.1006/jmbi.2001.4520. PMID 11273702.
- Joensuu T, Hämäläinen R, Yuan B; et al. (2001). "Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3". Am. J. Hum. Genet. 69 (4): 673–84. PMID 11524702.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Lazarowski ER, Shea DA, Boucher RC, Harden TK (2003). "Release of cellular UDP-glucose as a potential extracellular signaling molecule". Mol. Pharmacol. 63 (5): 1190–7. PMID 12695547.
- Lee BC, Cheng T, Adams GB; et al. (2003). "P2Y-like receptor, GPR105 (P2Y14), identifies and mediates chemotaxis of bone-marrow hematopoietic stem cells". Genes Dev. 17 (13): 1592–604. doi:10.1101/gad.1071503. PMID 12842911.
- Skelton L, Cooper M, Murphy M, Platt A (2003). "Human immature monocyte-derived dendritic cells express the G protein-coupled receptor GPR105 (KIAA0001, P2Y14) and increase intracellular calcium in response to its agonist, uridine diphosphoglucose". J. Immunol. 171 (4): 1941–9. PMID 12902497.
- Moore DJ, Murdock PR, Watson JM; et al. (2004). "GPR105, a novel Gi/o-coupled UDP-glucose receptor expressed on brain glia and peripheral immune cells, is regulated by immunologic challenge: possible role in neuroimmune function". Brain Res. Mol. Brain Res. 118 (1–2): 10–23. PMID 14559350.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.